黄政德教授从寒热错杂辨治脾胃病的临床经验

黄政德教授,主任医师,中医内科学博士研究生导师,国务院特殊津贴专家,第五批全国名老中医药专家学术经验继承工作指导老师,省级重点学科中医内科学带头人,擅长心血管疾病、消化系统疾病的诊治。黄政德教授在辨治脾胃病方面有独到的临床经验,注重整体观念和辨证论治,其疗效显著,现将黄政德教授从寒热错杂辨治脾胃病的临床经验进行总结。     

黄家驷教授与中国生物医学工程学

黄家驷教授是中国生物医学工程学的奠基人。他领导创建了中国生物医学工程学科,倡导生物医学工程研究,重视国际交流,推动生物医学工程学向纵深发展,为我国生物医学工程学的兴起、开拓和发展做出了杰出贡献。     

Development and Vibration Control of Frequency Adjustable Tuned Mass Damper Based on Magnetorheological Elastomer

Tuned mass dampers (TMD) have been widely used in passive vibration control, but their main disadvantage is that the vibration reduction effect may be greatly affected by the natural frequency of the main structure. In order to solve this limitation, we designed a frequency adjustable tuned mass damper (FATMD) based on a magneto rheological elastomer (MRE), which is a new type of magneto rheological smart material, with adjustable stiffness, obtained by changing the magnetic induction. We used MRE to change the stiffness of FATMD to track the natural frequency of the main structure. However, adding TMD will change the natural frequency of the system. Therefore, we combined Hilbert–Huang transform (HHT) and a natural excitation technique (NExT), with Simulink/dSPACE, to identify the natural frequency of the system in real time, and then calculated the natural frequency of the main structure through the TMD optimal design theory. This can help adjust FATMD to its optimum tuning state. To verify the applicability and effectiveness of FATMD, this paper compares the FATMD and traditional TMD experimental results. The natural frequency of steel beams can be changed by adding mass blocks. The experimental results indicate that FATMD, using the frequency tracking method, can effectively track the natural frequency of the main structure to ensure that the system is always in the optimum tuning state. In addition, FATMD can still achieve a good vibration reduction effect when the natural frequency of the main structure changes.     

《黄帝内经》中足三里穴的定位及主治功用

本文系统梳理了《黄帝内经》中涉及足三里穴的有关条文,依据经文原旨,参考注家有关注释,从腧穴名称、归经定位、取穴方法、针刺方法、主治病证等方面,对足三里穴主治功用、主治特点进行考证.     

黄连解毒汤有效部位抑制NogoA/NgR表达对脑缺血大鼠白质损伤的影响

目的:观察黄连解毒汤有效部位对脑缺血大鼠白质损伤的影响,探讨黄连解毒汤有效部位对轴突修复抑制信号勿动蛋白A(NogoA)和勿动蛋白受体(Nogo receptor, NgR)的调控作用。方法:将雄性SD大鼠随机分为假手术组、模型组、总生物碱组、总黄酮组、总环烯醚萜组。除假手术组外,其余各组大鼠采用线栓法建立大鼠大脑中动...     

黄芪银杏注射液联合治疗急性脑梗塞

目的:运用黄芪、银杏注射液联合治疗急性脑梗塞,观察其疗效.方法:136例发病在1周以内的脑梗塞患者,随机分为黄芪、银杏治疗组(简称治疗组68例)和血塞通组(简称对照组,68例),进行临床观察.结果:治疗组总有效率97%,明显高于对照组91%.结论:黄芪、银杏注射液联 合应用补气活血优于单纯活血化瘀之血塞通注射液,可明显改变临床症状.     

基于LC-MS/MS技术同时定量分析片仔癀中特征胰酶水解肽

目的：阐明片仔癀中的蛋白组,定量分析其中的特征胰酶水解肽,以提高片仔癀的质量控制水平。方法：优化总蛋白提取条件,采用二辛可宁酸(BCA)法测定总蛋白含量,利用鸟枪法蛋白组学表征片仔癀的蛋白组,并进一步选择含量较高、稳定性好、长度适宜的特征多肽作为目标分析物,采用在线能量分辨质谱法(online ER-MS)优化特征肽的离子对及最佳碰撞能,建立反相液相色谱-选择反应监测(RPLC-SRM)定量分析方法,测定11批片仔癀中目标多肽的含量。结果：利用UniProt数据库从片仔癀中共鉴定了来源于200个蛋白的343个肽段,以酶和骨架蛋白为主;筛选得到ALSSALHER、TLLEGEESR和VAPLGEEFR 3个特征肽,以其作为目标分析物进行定量分析,online ER-MS优化3个特征肽的定量参数离子对分别为m/z 492.3→799.4、517.3→819.4和509.3→637.3,碰撞能分别为25.0、24.4、28.6 eV。方法学验证符合定量要求,3个多肽类成分在各批片仔癀样品中均被检出(ALSSALHER:0.06～0.44μg·g^–1;TLLEGEESR:...     

基于药物代谢组学的中药及方剂中组分间协同增效作用

针对中药及方剂中多组分间配伍协同作用的特点,提出了利用药物代谢组学解析多组分间协同增效作用的机制的假说,并介绍了作者近期利用药物代谢组学研究方剂及组成药物相互关系的成果。