老年人带状疱疹性眼病的特点

目的 :探讨老年人带状疱疹性眼病 (HZO)的临床特点及治疗转归。方法 :将 78例老年组与 72例非老年组HZO病例进行回顾性对比研究。结果 :两组共有的眼部病变为睑皮疹、结膜炎、角膜炎和虹膜睫状体炎 ,但老年组还有继发性青光眼、视神经炎和颅神经损害导致之上睑下垂、眼睑闭合不全、角膜知觉缺失和眼外肌麻痹等眼部并发症。老年组全病程平均治愈时间比非老年组长 ,(47 3± 3 7)天比 (18 5± 5 6 )天 ,P <0 0 1。结论 :老年人带状疱疹性眼病并发症多且严重 ,所需治愈时间长 (P <0 0 1) ,强调疗程中加强对全身性疾病综合治疗的重要性。     

恶性肿瘤放化疗并发带状疱疹27例临床分析

目的　接受放化疗的恶性肿瘤患者并发带状疱疹的临床分析。方法　回顾性分析 1998年 1月至2 0 0 3年 11月的 2 7例恶性肿瘤放化疗并发带状疱疹的住院患者的临床资料、治疗方法、随访结果。结果　全组死亡 16例 (5 9% ) ,其中 11例 (41% )死于发病后 0 .5 a内 ,3例 (11% )死于发病后 1a内 ,2例 (7% )死于发病后 3a内。死亡的 16例患者中 ,播散型患者 7例 ,局限型患者 9例。结论　对恶性肿瘤放化疗并发带状疱疹应有足够的认识 ,以期早发现、早诊断、早治疗 ,减少不必要的并发症的发生     

儿童白血病合并暴发型水痘带状疱疹病毒感染临床分析

目的探讨白血病患儿合并水痘带状疱疹病毒感染的临床特点及防治措施.方法回顾性分析1995年1月～2003年2月某院收治的6例合并水痘带状疱疹病毒感染的白血病患儿病历情况.结果 6例患儿均有发热及典型皮损,其中4例为持续高热(39～40.4℃)达1周,皮疹均为全身性分布.6例患儿均治愈,无水痘并发症发生.结论白血病患儿合并水痘带状疱疹病毒感染多呈暴发性感染,临床症状较重,容易出现并发症,应采取积极有效的防治措施.大剂量静脉用免疫球蛋白联合抗病毒药物等综合治疗效果较好.     

Difference in pathogenesis between herpes simplex virus type 1 encephalitis and tick-borne encephalitis demonstrated by means of cerebrospinal fluid markers of glial and neuronal destruction

We determined the extent of neuronal and glial cell destruction in 13 patients with herpes simplex type 1 (HSV-1) encephalitis, 15 patients with tick-borne encephalitis (TBE), and 20 noninfectious controls by analyzing the cerebrospinal fluid (CSF) concentrations of neurofilament protein (a marker of neurons, mainly axons), neuron-specific enolase (a marker of neurons, mainly somas), glial fibrillary acidic protein, and S-100 protein (markers of astrocytes). In addition, in patients with HSV-1 encephalitis CSF samples were collected serially before 7, 8-14, and 18-49 days and 3-10 months after the onset of neurological symptoms. In the acute stage of HSV-1 encephalitis we found markedly higher CSF levels of the cell damage markers than in patients with TBE. The concentration of cell damage markers in HSV-1 encephalitis decreased within 45 days after acute infection, except for neurofilament protein. The CSF concentrations of neurofilament protein increased during the second week, remained extremely high throughout the next month, and decrease thereafter. The changes in these markers of neuronal and glial destruction demonstrate the neuronal and astroglial cell damage during the first month after HSV-1 encephalitis. In contrast, most patients with TBE had signs only of slight astrogliosis, except for two patients with paresis.     

UVN光疗仪治疗带状疱疹的临床分析

目的对UVN光疗仪治疗带状疱疹进行临床观察,寻找治疗带状疱疹的最佳方法。方法对418例患者分别采用UVN光疗仪联合阿昔洛韦及单纯阿昔洛韦治疗,并进行临床治疗的观察研究。结果UVN光疗仪联合阿昔洛韦治疗带状疱疹疗效明显优于单纯阿昔洛韦治疗,P<0.05。结论UVN光疗仪联合阿昔洛韦治疗带状疱疹,疗效可靠,可以阻止疾病炎性细胞浸润,促进患者早日康复。     

HSV-TK/GCV系统在难治性卵巢癌裸鼠移植瘤模型中的实验研究

目的:建立人难治性卵巢癌荷瘤裸鼠模型,用HSV-TK/GCV自杀基因系统治疗模型动物,观察疗效及协同因素。方法:常规培养携带HSV-TK基因的重组逆转录病毒包装细胞PA317,测定病毒滴度。在移植瘤内多点注射包装细胞,观察GCV、ATRA、TPT对移植肿瘤独立及协同治疗后的肿瘤体积变化。治疗结束后分析移植肿瘤组织病理,PCR检测TK基因在NIH3T3细胞及移植肿瘤组织的转导。结果:人卵巢癌标本裸鼠原代移植成功率16.7%,鼠间传代移植成功率89.7%;重组逆转录病毒滴度为6×104cfu/ml;HSV-TK/GCV系统或TPT治疗后肿瘤生长受到抑制(P<0.05),两者联合治疗后,抑制更明显(P<0.05);ATRA灌胃未显示独立或协同治疗作用(P>0.05);HSV-TK/GCV组、TPT组及两者联合组有明显的治疗反应;PCR检测证实,TK基因在NIH3T3细胞及肿瘤组织中的转导。结论:HSV-TK/GCV系统及TPT对人难治性卵巢癌荷瘤裸鼠有单独及协同治疗作用,全反式维甲酸灌胃对人难治性卵巢癌荷瘤裸鼠疗效不明显。     

更昔洛韦、泛昔洛韦治疗带状疱疹的成本-效果分析

目的 评价更昔洛韦注射剂与泛昔洛韦胶囊治疗带状疱疹构成本及其效果。方法 将符合带状疱疹典型临床症状的门诊患者共84例，随机分为两组，分别给予更昔洛韦注射剂与泛昔洛韦胶囊治疗，副反应评价指标按卫生部1994年不良反应制定标准。结果 更昔洛韦与泛昔洛韦的治愈率分别为86．0％和82．9％，显效率分别为100％和95．1％，但泛昔洛韦的成本效果比明显低于更昔洛韦。结论 泛昔洛韦更具有成本-效果优势。     

Characteristics of facial nerve palsy during childhood in Japan: frequency of varicella–zoster virus association

BACKGROUND: The aim of this study was to clarify the clinical characteristics of facial nerve palsy and the frequency of varicella-zoster virus association in Japanese children, retrospectively. METHODS: The subjects were 30 facial nerve palsy patients less than 15 years old, treated in the Department of Pediatrics, Kawasaki Medical School Hospital, Okayama, Japan, during the last 10 years. RESULTS: The male/female and right/left ratios were 16/14 and 16/13, respectively. The patients included 21 cases (70%) of Bell's palsy, four cases (13%) due to otitis media, three cases (10%) of Ramsay Hunt syndrome and two cases (7%) due to birth trauma. There were six cases of zoster sine herpete among the Bell's palsy cases. CONCLUSION: Varicella-zoster virus-associated facial palsy was found in nine (36%) of the 25 patients examined. Zoster sine herpete was more frequently encountered in children than adults. Ramsay Hunt syndrome was found in school-age children and zoster sine herpete was often found in preschool children. The period of recovery was fast for facial nerve palsy due to acute otitis media, which occurred within 23 months of age, after myringotomy and administration of antibiotics.     

Clinical observations on the treatment of Ramsay Hunt syndrome by blood-letting puncture and cupping as main therapy

目的:观察穴位刺络拔罐疗法配合针灸等治疗Ramsay Hunt综合征的临床疗效.方法:治疗组32例患者取大椎、完骨等穴运用梅花针刺络拔罐的方法配合针灸治疗;对照组32例患者以针灸、阿昔洛韦等治疗.结果与结论:4个疗程后治疗组愈显率为81.2%,对照组为56.2%,治疗组优于对照纽(P<0.05).且治疗组中、短期耳痛缓解率也均明显优于对照组(P<0.01).     

43例海洛因依赖者并发带状疱疹和HIV感染分析

目的 :了解海洛因依赖者中并发带状疱疹和感染HIV之间的关系。方法 :对收治的戒毒人员中并发带状疱疹的患者进行抗 -HIV抗体检测。结果 :海洛因依赖者中并发带状疱疹的 4 3例患者抗 -HIV抗体均为阳性。结论 :在今后的戒毒治疗中 ,如遇感染带状疱疹的患者 ,应高度怀疑为HIV感染者或进入艾滋病发病期的病人 ,在诊断治疗、护理、隔离和防护工作中应予以高度重视。