中药类产品国际市场分析

近年来,包括中药在内的植物药和传统药日益受到世界各国的重视和青睐。2015年,全球植物药市场销售额为931.5亿美元。但据中华人民共和国工业和信息化部最新统计数据显示,2014年我国中成药及饮片的销售额约1200亿美元。为进一步明确全球中草药市场现状及中药产品的国际市场份额,本研究从 PubMed 数据库、政府网站、研究报告及搜索引擎中收集相关数据,分析世界主要国家和地区的传统药物市场现状。结果显示,中药类产品包括中成药、中药饮片、中药提取物、中药保健品的国内外市场销售额约为1350亿美元,而我国中药类产品(不包括保健品)约占国际中草药或传统药物市场的80%。     

双助益肠汤配合中药贴脐热敷治疗脾肾两虚型慢性结肠炎83例

[目的]观察双助益肠汤配合中药贴脐热敷治疗脾肾两虚型慢性结肠炎疗效。[方法]对83例患者内服自拟"双助益肠汤"水煎服,配合中药贴脐热敷,观察60天判定疗效。[结果]治愈22例(26.51%),显效29例(34.94%),好转26例(31.33%),无效6例(7.23%),总有效率为92.77%。[结论]双助益肠汤配合中药贴脐热敷治疗慢性结肠炎,内外合治,相互补充,标本兼顾,疗效确切,值得推广应用。     

中药洗剂联合萘替芬酮康唑乳膏治疗手足癣疗效观察

目的:观察中药洗剂联合萘替芬酮康唑乳膏治疗手足癣临床疗效。方法:将112例患者随机分为两组,治疗组62例给予中药洗剂,联合萘替芬酮康唑乳膏外涂治疗,对照组50例给予萘替芬酮康唑乳膏,观察治疗效果。结果:治疗组疗效明显优于对照组,有显著性差异(P>0.05)。结论:中药浸泡联合萘替芬酮康唑乳膏治疗各种手足癣,疗效明显优于单用萘替芬酮康唑乳膏。     

根管治疗约诊间疼痛的临床控制

目的:通过磨牙根管治疗过程中3种根管内封药方法的疗效比较,探讨根管治疗约诊间疼痛(EIAP)的控制措施.方法:将262例患者274颗患牙据根管预备后根管内封药分为Vitapex糊剂组、氢氧化钙糊剂组以及樟脑酚药尖组,1周后约诊,观察记录患者的疼痛、肿胀情况.结果:根管治疗过程中约诊间疼痛的发生率Vitapex糊剂组较其...     

基于"欧盟草药专论"解析中药欧盟注册关键问题

欧盟2004/24/EC法令针对传统草药药品实行简化注册程序,很大程度降低了草药药品上市门槛,但法令为其额外设定的注册条件,如草药在欧盟至少药用15年历史要求、适应症限制、给药途径限制等,对非欧洲本土来源的中药产品而言仍面临诸多挑战.鉴于"欧盟草药专论"的评价与草药药品简化注册中安全性和有效性的审评标准基本一致,首次从欧盟草药专论的角度,跟踪欧盟草药专论最新评价进展,对影响欧盟草药专论建立的关键因素以及中药产品简化注册过程中的关键问题进行深入分析,并提出建议与对策,以期为中药产品欧盟注册提供一定指导和参考.     

Analysis of Carbonation Behavior of Cracked Concrete

The crack and carbonation of concrete pose a great challenge to its durability. Therefore, this paper studies the effect of cracks on the carbonation depth of cement paste under different factors. The relationship between carbonation and cracks was determined, and the carbonation mechanism of cement paste with cracks was clarified. The results show that a small water–binder ratio can effectively inhibit the carbonation process. The bidirectional carbonation enlarged the carbonation area around the crack. Within 21 days of the carbonation, the carbonation depth increased with carbonation time, and the Ca(OH)₂ on the surface of the specimen was sufficient, allowing for a convenient chemical reaction with CO₂. The influence of crack width on the carbonation process at the crack was greater than the influence of the crack depth. Carbonation influenced the hydration of cement-based materials, altering the types and quantities of hydration products. In conclusion, accurately predicting the regularity of carbonation in cracked structures is critical for improving the durability of concrete.     

蜂蜜干膏的质量研究

目的 建立蜂蜜干膏的质量标准.方法 采用文献调研、性状、检查和含量测定等方法进行研究.结果 观察了样品的性状特征,建立了样品的检查和含量测定方法.结论 所建立的标准可用于蜂蜜干膏的质量控制.     

负压封闭引流技术加中药治疗对创面肉芽组织生长的影响

目的:通过临床研究探讨负压封闭引流技术(VSD)加中药治疗对创面肉芽组织生长的影响,并初步阐明其作用机理。方法:将30例患者分为治疗组和对照组,其中治疗组为VSD加中药组15例,对照组为VSD组15例。比较2组的创面肉芽生长情况,测定经治疗后1、3、5、7d创面渗出液IL-1、IL-6和TNF-α的水平,评估疗效。结果:治疗组与对照组在创面肉芽生长方面相比差异有统计学意义(P<0.05),在IL-1、IL-6和TNF-α方面均表现为细胞因子水平升高,但2组比较差异无统计学意义(P>0.05)。结论:VSD加中药治疗对创面修复具有有利的影响,中药在创面肉芽组织生长方面具有重要作用,其机理可能为促进IL-1、IL-6和TNF-α的水平的上调。     

Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals

Laghupatha (Cissampelos pareira) a important medicinal plant in Indian traditional system of medicine and is widely used in many countries by different tribal. Despite the wide use of Cissampelos pareira in folk medicine, no study has been published in the scientific literature about its toxicological profile. In present study 50% aqueous ethanolic extract of Cissampelos pareira (Menispermaceae) was evaluated for the acute and subacute toxicity. In the acute toxicity test, oral administration of 2g/kg of Cissampelos pareira produced neither mortality nor changes in behavior or any other physiological activities in mice. In subacute toxicity studies, no mortality was observed when the two doses of 1 or 2g/kg day of 50% aqueous ethanolic extract of Cissampelos pareira were administered p.o. for a period of 28 days in rats. There were no significant changes occurred in the blood chemistry analysis including glucose, sodium, potassium, calcium, phosphorus, chloride, total cholesterol, high density lipoprotein, triglycerides, total protein, blood urea nitrogen, creatinine, conjugated billirrubin, aspartate transaminase, alanine transaminase, total billirrubin, albumin, prothrombin time and thromboplastin partial time in both sexes of animals. Hematological analysis showed no marked differences in any of the parameters examined (WBC count, platelet and hemoglobin estimation) in either the control or treated group of both sexes. The urinalysis was negative for glucose, ketonic bodies, casts, red blood cells, and albumin in the control and treatment groups. There were no significant differences in the body and organ weights between controls and treated animals of both sexes. Pathologically, neither gross abnormalities nor histopathological changes were observed. Cissampelos pareira was found safe in acute and subacute toxicities while chronic toxicity studies are further required for the support of the safe and sound use of this traditional plant.