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81.
目的 探讨垂黄清脉冲剂对冠心病稳定型心绞痛(热毒痰瘀证)患者NF-κB信号通路的调控。方法 本试验研究方法采用单盲、随机、对照法,选取就诊于宁夏医科大学总医院临床诊断为冠心病稳定型心绞痛(热毒痰瘀证)患者94例,将其随机分入对照组48例和试验组46例。两组均给予内科常规西药治疗,对照组加服银丹心脑通软胶囊,试验组加服垂黄清脉冲剂,疗程为3个月。于治疗前、后记录患者的基本情况,并采集血清样本,用酶联免疫吸附测定法(Elisa法)检测血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1、NO浓度水平进行对比,用SPSS22.0将数据进行统计学分析。结果 与治疗前比较,两组治疗后Gensini积分、血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1浓度水平均较治疗前显著降低,NO浓度水平显著升高(P < 0.05,P < 0.01),其中试验组显著程度尤为明显(P < 0.01)。与治疗后对照组比较,试验组Gensini积分、血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1浓度水平降低,NO浓度水平升高趋势更明显(P < 0.01)。结论 垂黄清脉冲剂治疗冠心病稳定型心绞痛(热毒痰瘀证)在改善患者症状;改善冠状动脉管腔狭窄程度;通过降低炎症标志物TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1的水平,减小ET-1/NO比值,从而对NF-κB信号通路进行部分调控,以有效抑制或截断血管内皮的炎症级联反应过程,清除炎症损伤因素以及保护血管内皮功能等方面均有显著优势,临床疗效确切值得肯定和推广应用。  相似文献   
82.
83.
雄激素不敏感综合征(androgen insensitivity syndrome,AIS)又称为睾丸女性化综合征(testicular feminization syndrome,TFS),是一种X连锁遗传病,是男性假两性畸形中较常见的类型,可分为完全型AIS和不完全型AIS,其原因主要是雄激素受体(androgen receptor,AR)基因的突变导致其对雄激素产生抵抗和不应答。本文回顾南京医科大学附属妇产医院2例CAIS患者的临床资料及诊疗过程,以期能进一步提高对该病的认知及诊治水平。  相似文献   
84.
吉兰―巴雷综合征(GBS)是一种以快速进行性四肢麻木无力为特点的急性炎性脱髓鞘性多发性多神经根神经病。随着外源性神经节苷脂在临床的广泛应用,该药引起的副作用也逐渐显现,外源性神经节苷脂相关性GBS是其最严重的并发症,临床上主要表现为轴索型GBS,以四肢弛缓性瘫痪为首发症状,表现为急性、严重且快速进展的周围神经受累,较其他轴索型GBS病情重,恢复时间长,预后差。目前发病机制尚不明确。静脉注射人免疫球蛋白是其具有循证医学证据的治疗方法,目前已取代血浆置换成为GBS首选治疗方法,推荐剂量为0.4 g/(kg·d),连续静滴5 d,大剂量激素治疗的效果还有待进一步探讨。早发现、早诊断、尽早停用外源性神经节苷脂、及时应用人血免疫球蛋白冲击治疗和康复治疗,可改善预后。  相似文献   
85.
Gray platelet syndrome (GPS) is a rare (<1/1 000 000) and inherited platelet function disorder characterized by macrothrombocytopenia, α-granule deficiency, and hemorrhages. Bleeding intensity does not correlate with platelet count nor with functional test results. We hereby describe the perioperative bleeding prevention and management of a patient with GPS requiring multiple redo cardiac surgeries.  相似文献   
86.
《Clinical therapeutics》2019,41(5):836-847
PurposeA role for the immune system in causing myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) is long suspected, but few studies have looked for specific autoantibodies that might contribute to the symptoms. Our aim was to look for evidence of antibodies to neuronal proteins in patients with ME/CSF.MethodsSera samples from 50 patients and 50 healthy individuals were sent coded to the Neuroimmunology Laboratory in Oxford. Screening for antibody binding to neuronal tissue was performed on brain tissue and neuronal cultures. Specific serum antibodies were assessed by antigen-specific cell-based assays and radioimmunoassays. After antibody testing, the associations between seropositive status and clinical data were investigated.FindingsOverall, 8 patients and 11 participants were found to have some serum immunoreactivity toward neuronal or neuromuscular junction proteins, but only 1 patient and 2 participants had specific serum antibodies. Nevertheless, seropositive status in patients with ME was associated with shorter duration since onset and a more severe disease.ImplicationsThe results indicate no overall increased frequency of antibodies to neuronal proteins in ME/CSF and no evidence of a specific antibody that might be causative or contribute to clinical features in patients. However, the association of seropositive status with shorter duration of disease and more severe symptoms suggests a possible role of antibodies at onset in some patients and should be the focus of future studies.  相似文献   
87.

Background

In Leriche syndrome, postoperative graft thrombosis remains one of the most significant clinical challenges.

Methods

We reviewed 51 patients who underwent surgery for aortoiliac occlusive disease at our hospital from January 2007 to December 2014. The factors associated with graft patency were determined using the Cox proportional hazard model.

Results

The 2-year prosthetic graft patency rate was 72.5%. Younger age (p = 0.017, Odd ratio (OR) = 1.112), postoperative uncontrolled hypertension (p = 0.044, OR = 3.797), and associated Trans Atlantic Inter-Society Consensus for the Management of Peripheral Arterial Disease II (TASC II) D femoropopliteal lesion (p = 0.008, OR = 11.139) were significantly related factors for prosthetic graft patency after surgical repair. The existing comorbidities of the patients that indicated the need for axillo-bifemoral bypass seemed to be related to lower graft patency or other complications.

Conclusions

For better graft patency after an open surgical repair of Leriche syndrome, strict postoperative hypertension control and distal run-off resolution are necessary.  相似文献   
88.
89.
目的:分析鼻塞式同步间歇正压通气(NIPPV)联合布地奈德雾化治疗ARDS(新生儿急性呼吸窘迫综合征)疾病的临床应用效果。方法:纳入病例是2017年5月—2019年11月收治的104例ARDS新生儿,随机平均分为两组。参照组52例采纳CPAP(持续气道正压通气通气)治疗,实验组52例采纳NIPPV+布地奈德雾化治疗,对比两组呼吸机通气时间、用氧时间、住院时间、血气指标以及并发症发生情况。结果:实验组呼吸机通气时间、用氧时间、住院时间均明显短于参照组,差异有统计学意义P<0.05;实验组治疗3 d后PaCO2明显低于参照组,实验组治疗3 d后PH以及PaO2明显高于参照组,差异有统计学意义P<0.05;实验组并发症发生率(3.85%,2/52)明显低于参照组(21.15%,11/52),差异有统计学意义P<0.05。结论:NIPPV+布地奈德雾化可有效缩短ARDS患者机械通气时间,改善血气指标,降低并发症发生率,值得借鉴。  相似文献   
90.
Abstract

This study is a single-center, retrospective analysis of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60?mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene?+?laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene?+?laser group compared with the laser treatment group (?87% vs???34%, respectively), and the vestibular health score started declining faster in the ospemifene?+?laser group. Although, additional research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clinical effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause.  相似文献   
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