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81.
Elevation of serum CA125 in carcinomas of the fallopian tube, endometrium, and endocervix 总被引:9,自引:0,他引:9
J M Niloff T L Klug E Schaetzl V R Zurawski R C Knapp R C Bast 《American journal of obstetrics and gynecology》1984,148(8):1057-1058
An immunoradiometric assay with the use of a monoclonal antibody can detect an antigenic determinant (CA125) in peripheral blood from more than 80% of patients with epithelial ovarian cancer. In this report elevated levels of CA125 were detected in serum from patients with adenocarcinomas of the fallopian tube, endometrium, and endocervix. Among patients with endometrial cancer, CA125 levels were elevated in recurrent or disseminated disease but not with tumors confined to the uterus. 相似文献
82.
83.
An epidemic of "childbed fever" 总被引:2,自引:0,他引:2
Postpartum infection remains a cause of considerable maternal morbidity and occasional maternal mortality. Puerperal sepsis mediated by what is now known as group A beta-hemolytic streptococci or Streptococcus pyogenes was once a common and lethal nosocomial scourge. Fortunately, multiple developments have decreased the incidence and ameliorated the clinical course of group A beta-hemolytic streptococcal postpartum sepsis. Despite these developments, epidemic group A streptococcal sepsis still jeopardizes modern mothers. We describe an epidemic of five women with group A beta-hemolytic streptococci-mediated postpartum infections which occurred at Mather Air Force Base Hospital, Sacramento, California. The remarkable, yet characteristic signs, symptoms, and clinical course of these patients are briefly reviewed along with the epidemiologic methods which led to the discovery of the common nosocomial source. Familiarization of the clinical aspects of these patients and the methods used to eradicate this epidemic will facilitate the protection and care of other women. Unfortunately, modern mothers still remain in jeopardy from "childbed fever." 相似文献
84.
F W Schweizer M H Kim W B Malarkey 《American journal of obstetrics and gynecology》1984,149(4):367-371
Although it seems likely that some patients with unexplained repeated abortions have early or subclinical autoimmune disease, there are no reports on the incidence of autoimmune serologic abnormalities in such patients by use of a series of tests. This diagnosis would suggest a treatable etiology for reproductive loss. We performed 11 serologic autoimmune tests in sera from 14 patients with three or more unexplained abortions (group II) and compared these results to those of 16 control patients with an established diagnosis for repeated abortions (group I). The groups were similar in age, gravidity, number of spontaneous abortions and live births, and in the interval from last abortion to serum sampling. A positive antinuclear antibody test plus at least one other positive test was found in four of 14 (29%) patients in group II (p less than 0.05). The tests that identified all these patients included levels of antinuclear antibody, antibodies to DNA or extractable nuclear antigen, and low levels of complement 3. 相似文献
85.
86.
Josh C. Tunca 《American journal of obstetrics and gynecology》1983,147(8):893-896
Ninety-seven gynecologic cancer patients received a thorough nutritional assessment during the initial evaluation of their disease. Patients with Stages III and IV ovarian cancer were shown to have severe protein-calorie malnutrition (p < 0.01) unrelated to any gastrointestinal obstruction or laparotomies. Patients with other types of gynecologic cancers at all stages demonstrated nearly normal nutritional assessment parameters, with the exception of recent weight loss. Nutritional assessment and active nutritional intervention therapy are suggested especially for patients with advanced ovarian cancer. 相似文献
87.
Shai Linn Stephen C. Schoenbaum Richard R. Monson Bernard Rosner Phillip G. Stubblefield Kenneth J. Ryan 《American journal of obstetrics and gynecology》1983,147(8):923-928
Previous reports have linked the use of oral contraceptives and spermicides to the occurrence of malformations in offspring. With information from 12,440 women interviewed during the delivery hospitalization we found no relationship between contraceptive method and the occurrence of malformations. Whereas any unnecessary drug should be avoided during pregnancy, prior contraceptive method seems to be unrelated to the risk of congenital malformations. 相似文献
88.
89.
Richard Reid 《Gynecologic oncology》1983,15(2):239-252
Evidence of a biologically significant association between subclinical papillomavirus infection (SPI) and cervical neoplasia raises the question of whether this is a causal relationship. Human papillomavirus (HPV) infection of metaplastic epithelium in the cervical transformation zone is relatively common, producing latent infection in susceptible persons. The epidemiological characteristics of SPI and cervical cancer are essentially identical and there is a strong clinico-pathological association between condylomas and anogenital carcinoma. Tissue culture cells have been transformed from a normal to a neoplastic phenotype by animal papillomaviruses, and there is preliminary data reporting upon the successful identification of HPV genomic sequences in tumor cells. SPI commonly coexists with foci of cervical intraepithelial neoplasia (CIN). Areas of apparent transition are seen, and these two lesions are linked by a discernible spectrum of morphologic change. Such circumstantial evidence gives biological plausibility to the suggestion that HPV may be a cervical carcinogen. It is postulated that cervical neoplasia arises by progression from benign viral hyperplasia, through varying stages of koilocytotic atypia with associated dysplasia, to unremarkable carcinoma in situ. Invasion is presumed to reflect the emergence of an aggressive heteroploid clone, an age-related decline in host immune surveillance or an interaction of both factors. 相似文献
90.
妇科腹腔镜手术与开腹手术对心肌酶谱及神经内分泌激素的影响 总被引:1,自引:0,他引:1
目的:比较腹腔镜妇科手术及开腹手术对病人心肌酶谱及神经内分泌激素的影响。方法:40例ASAⅠ~Ⅱ级,年龄27~55岁,在硬外麻下择期行妇科手术的病人,按手术方式不同分为两组。L组(n=20),在腹腔镜下手术;O组(n=20),行开腹手术。两组均于手术开始前、术后第1天早晨7时抽左肘静脉血3ml,检查血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)。另于术前、手术开始后20min、术毕和术后10h、24h采集血样,应用放免法测血清皮质醇、胰岛素和T3、T4、TSH的水平。结果:(1)L组CK、AST术后24h均明显高于术前(P<0·01),O组除LDH术后高于术前外(P<0·01),其他指标均无明显差异;(2)两组术前和术后24h测定的各项内分泌激素无显著差异(P>0·05)。L组皮质醇于术毕明显增高,但与手术前比较,无统计学差异(P>0·05)。两组胰岛素的变化均无显著差异(P>0·05)。O组皮质醇术毕及术后10h较手术前明显升高(P<0·05);O组皮质醇除术前外均显著高于L组相同时点值(P<0·05)。O组胰岛素术后10h明显高于手术前水平(P<0·05)。两组围术期T3、T4和TSH均无明显变化。结论:腹腔镜手术CO2气腹对心肌酶的影响较开腹手术大,但应激反应小于开腹手术。 相似文献