万艾可治疗ED时对BPH引起LUTS改善的研究

目的 :探索、研究万艾可在治疗阴茎勃起功能障碍 (ED)时对由良性前列腺增生 (BPH)引起的下尿路症状(LUTS)的影响。　方法 :32例ED同时伴有BPH的研究对象 ,采用IIEF 5问卷表和IPSS评分表 ,在服用万艾可前和服药后 6个月分别各填写一次 ,应用单因素方差分析对所得到的前后评分进行统计学分析。结果 :在服药前32例ED中 ,轻、中、重分别为 14、13、5例 ,BPH中轻、中、重分别为 3、15、14例 ;服药后IIEF 5评分平均上升4 2 .36 % ,IPSS评分平均下降 2 0 .14 % ,两者在统计学上都有显著性差异 ,P <0 .0 1。　结论 :在治疗中老年性ED合并BPH中 ,应用万艾可既能治疗ED ,取得完美的性生活 ,又能达到改善由BPH引起的LUTS。万艾可是一治疗ED有效的药物 ,但对于前列腺基质平滑肌亦有辅助性松弛作用 ,因此也有助于BPH时LUTS的缓解。     

Chronic Fatigue: A Survey, Outcome Study and Proposals

Background:  Sample sizes in studies of childhood chronic fatigue remain small and there is a need to integrate research findings and establish common criteria.
Method:  This is a detailed report of 20 children with medically unexplained fatigue, referred to as Chronic Fatigue Syndrome (CFS). It includes an uncontrolled outcome study of treatment based on a pragmatic cognitive-behavioural model adapted for children at Great Ormond Street Hospital for Children.
Results:  The data revealed psychological distress at 30 times the prevalence found in the normal child population, with specific high-ranking symptoms, including headache, social withdrawal and decreased appetite. Onset tended to occur at 11 years of age with some earlier problems at school age, suggesting it might be possible to identify those most at risk. Follow-up demonstrated improvement in 87% of the sample (parental report), a significant increase in school attendance and a significant decrease in symptom severity. Factors associated with good outcome were short duration of fatigue (less than a year) and behaviours that tended to combat the cycle of avoidance, such as carefully planned home-tuition.
Conclusions:  Recording a comprehensive range of symptoms and factors facilitates comparisons within and between child studies. It is proposed that symptom severity is a particularly relevant measure for Chronic Fatigue Syndrome which is characterised by persisting symptoms.     

Neuropsychologic symptoms in the migraine syndrome

Twenty patients with complex neuropsychologic symptoms associated with classic migraine were selected from a group of 200 patients with vascular headache. Twenty types of symptoms were found and grouped into six categories (language, visual symptoms, cognitive-dysmnesic symptoms, olfactory-gustatory hallucinations, automatisms, and somatosensory symptoms). Some of the symptoms found have apparently not been reported previously. The importance of the analysis of this complex neuropsychologic set of symptoms and of the possible consequences of complicated, frequent vascular headache is emphasized.     

Acute Myocarditis

ABSTRACT In a prospective study, 57 patients with a preliminary diagnosis of myocarditis were investigated. Twenty-four patients were considered to have an acute myocarditis, 14 had a suspected myocarditis, while in 19 patients myocarditis was excluded. Episodes of frequent supraventricular and/or ventricular extrasystoles during hospital stay were seen in 8/24 cases (33%) with myocarditis and in 1/19 cases (5%) without myocarditis. On follow-up 1 month later, no supraventricular extrasystoles were observed in either group. Echocardiographic signs consistent with left ventricular insufficiency were noted in 7/24 cases (29%) with myocarditis, in 1/14 cases (7%) with suspected myocarditis and in no case without myocarditis. With a “routine” serologic test battery covering influenza viruses A and B, adenovirus, Coxsackie virus group B, ECHO viruses, Chlamydia psittaci, Mycoplasma pneumoniae and hemolytic streptococci group A, a possible etiology could be documented in 9/24 cases (38%) with myocarditis and in 4/19 cases (21%) without myocarditis. Enterovirus-specific IgM was detected with solid-phase reverse immunosorbent test (SPRIST) in 12/23 (48%) cases with myocarditis and in 3/16 cases (19%) without myocarditis. In SPRIST-IgM-positive cases, IgM antibodies were detected in 15/20 (75%) of the sera taken on admission. The overall serological results indicated a recent infection in 16/24 cases (67%) with myocarditis and in 5/19 cases (26%) without myocarditis (p < 0.05).     

Low surface tension calcium hydroxide solution is an effective antiseptic

The antimicrobial effects of a saturated calcium hydroxide solution, and in combination with 10% and 20% detergent, were evaluated on Streptococcus faecalis. Strepto-coccus sanguis, Streptococcus mutans, Streptococcus salivarius, Neisseria sp., diphlheroid, Staphylococcus aureus, Lactobacillus sp., Staphylococcus epidermidis, Bacillus suhtilis and Candida albicans. The saturated calcium hydroxide solution was effective against only four of the 11 microorganisms studied over a 60-min exposure time. The calcium hydroxide solutions con-taining detergent killed all 11 test organisms over a 30-min exposure time. This difference was statistically significant (P<0.01). No statistically significant difference in antimicrobial action was found between the 10% and 20% detergent calcium hydroxide solutions (F>0.01). However, the low surface tension (46.5 × 10^?3 Nm^?1) and high pH (10.8) of the calcium hydroxide solution with 20% detergent establish it as the more effective solution.     

牙髓根管感染厌氧菌培养结果分析

从３４例牙髓根管感染中共分离出厌氧菌１１８株，经菌属分类依次为消化链球菌属，拟杆菌属，梭杆菌属，放线菌属，韦荣氏球菌属和珠网菌属，其中前３属为７７株，分离率为６５．３％，这一结果显示该３属细菌与极管感染有密切关系，是牙髓根管感染的优势菌。     

Dorsal root ganglia cocultured with macrophages: an in vitro model to study experimental demyelination

The present investigation introduces an in vitro model to study macrophage properties during demyelination. Rat dorsal root ganglia (DRG) were cultured for obtaining myelinated peripheral nerve fibers. These cultures were exposed to non-resident macrophages. In untreated control cultures, there was no indication of myelin removal by the added macrophages. DRG were exposed to enzymatically generated oxygen radicals using the xanthin/xanthin oxidase or the glucose/glucose oxidase system. Assessment of Schwann cell viability and ultrastructural morphology revealed different patterns of cell cytotoxicity and morphological changes in different experiments. High concentrations caused complete tissue necrosis of the DRG, while low concentrations did not affect either cell viability or ultrastructural morphology. Under intermediate experimental conditions, oxygen radicals caused non-lethal Schwann cell damage leading to Schwann cell retraction and myelin sheath rejection. Myelin lamellae were disrupted and decompacted. These changes were followed by a selective macrophage attack on myelin sheats, resulting in demyelination. Axons, Schwann cells and sensory ganglion cells survived this attack. The specificity of the oxygen radical effects was tested in experiments using the oxygen radical scavengers catalase and superoxide dismutase. Catalase prevented the described effects on cell morphology and subsequently blocked demyelination by non-resident macrophages.Supported by a grant from the Deutsche Forschungsgemeinschaft (DFG) (Br 1274/1-1)     

主观症状及实验检查诊断早期干眼症

目的 分析主观症状及实验检查对早期干眼症患者诊断的意义。方法 对55例（109眼）已确诊的早期干眼症患者（无或仅伴有轻微体征）的临床症状及实验检查进行回顾性分析及比较。结果 患者中主观症状所占比率：干涩感94％，视疲劳感82％，异物感74％，明显高于其他症状（P〈0．05）。实验检查的阳性率：基础泪液分泌试验（Schirmer I test，SIt）35％，泪膜破裂时间检查（break-up time，BUT）85％，角结膜荧光素（fluorescent，FL）染色60％，其中BUT阳性率明显高于SIt和FL（P〈0．05）。结论 主观症状及实验检查可为早期干眼症诊断提供有利依据。     

马来西亚寒邪致病及其证治初探

根据第一作者在马来西亚从事中医临床工作50余年的经验,以中医理论为指导,探讨了在炎热的马来西亚,寒邪致病的可能性、客观性以及寒邪致病的病因、病机、临床表现特征及其治疗方法。     

The use of coaxially aligned freeze-thawed skeletal muscle autografts in the repair of the cauda equina — in the sheep

Summary The aim was to develop a model for study of nerve regeneration in nerve roots above the level of the dorsal root ganglion and to investigate the use of freeze-thawed muscle autografts for repair of nerve roots at this level.Four adult sheep were used for the experiment. A laminectomy was performed at the lumbosacral junction and the S2 root identified. Both the dorsal and ventral S2 roots were divided unilaterally within the dura and a freeze-thawed muscle graft was inserted into the nerve gap.When assessed at 6 months an action potential was recordable from the ventral root in one sheep. Histological examination of the nerve roots showed evidence of regeneration across the graft in the ventral roots of all the sheep and the dorsal roots of some.This preliminary work indicates a capacity for regeneration of the cauda equina and that freeze-thawed muscle can support this. It provides a useful model for further study of nerve root repair.