口腔颌面外科围手术期血糖管理专家共识

围手术期血糖水平异常现象是影响患者预后的重要因素。目前,已有较多关于外科手术围手术期血糖管理指南,但对于口腔颌面外科手术围手术期血糖异常情况尚未有规范的管理方案。根据已发表的相关指南、共识及文献,并结合颌面外科的特点及我们的经验,本文主要从术前高血糖的筛查、评估,术中血糖安全管理,术后血糖水平的监测及治疗等方面规范了标准化血糖管理操作规程,为颌面外科围手术期血糖管理提供参考。     

Liquid biopsies for colorectal cancer: a narrative review of ongoing clinical trials and the current use of this technology at a comprehensive cancer center

ObjectiveIn this review, we summarize ongoing clinical trials involving liquid biopsies (LB) for colorectal cancer (CRC), outlining the current landscape and the future implementation of this technology. We also describe the current use of LB in CRC treatment at our institution, the Mayo Clinic Enterprise.BackgroundThe use of LB in CRC treatment merits close attention. Their role is being evaluated in the screening, non-intervention, intervention, and surveillance settings through many active trials. This, coupled with the technique’s rapid integration into clinical practice, creates constant evolution of care.MethodsReview of ClinicalTrials.gov was performed identifying relevant and active trials involving LB for CRC. “Colorectal cancer” plus other terms including “liquid biopsies” and “ctDNA” were used as search terms, identifying 35 active trials.ConclusionsLB use for the CRC is actively being investigated and requires close attention. Based on current evidence, Mayo Clinic Enterprise currently uses LB in the non-interventional, interventional and surveillance setting, but not for screening. Results of these trials may further establish the use of LB in the management of CRC.     

Use of oral contraceptives and risk of pancreatic cancer in women: A recalculated meta-analysis of prospective cohort studies

In a recent systematic review and meta-analysis of observational studies, the author found potential errors in the selection and extraction processes. The recalculated summary relative risks and the results of a dose-response meta-analysis showed that oral contraceptive use may not be associated with the risk of pancreatic cancer in women.     

不同修复方法修复口腔颌面部肿瘤术后缺损的效果比较

目的探讨不同修复方法修复口腔颌面部肿瘤术后缺损的效果。方法选取口腔颌面部肿瘤根治术后缺损患者89例,根据最终选取的修复方案分为A组(n=49)和B组(n=40),A组给予股前外侧嵌合皮瓣修复,B组给予串联皮瓣修复。观察2组手术情况,采用华盛顿大学头颈肿瘤生活质量量表(UW-QOL)对患者术后生活质量进行评价,检测唾液中唾液酸(SA)及癌胚抗原(CEA)水平。结果 A组手术时间、胃管拔除时间和经口进食时间分别为(6.30±1.19)h、(19.77±2.81)d和(20.32±2.19)d,明显少于B组(P<0.05);但A组皮瓣制作时间为(1.20±0.28)h,明显多于B组(P<0.05)。A组术后6个月UW-QOL量表中外观、吞咽、咀嚼、言语、肩功能、情绪评分分别为(63.29±4.54)分、(54.93±5.03)分、(47.12±6.02)分、(64.49±4.33)分、(82.20±5.43)分和(75.50±7.20)分,明显高于B组(P<0.05)。A组和B组术后6个月UW-QOL量表中疼痛、活动、娱乐、味觉、唾液及焦虑评分比较差异无统计学意义(P>...     

口腔鳞状细胞癌中p27与Skp2蛋白表达及其意义的初步观察

目的:探讨p27与Skp2蛋白在口腔鳞状细胞癌组织中的表达及其与口腔鳞状细胞癌临床病理之间的相互关系。方法:免疫组化SP法检测p27、Skp2蛋白在69例口腔鳞状细胞癌和12例正常口腔黏膜组织中的表达情况,并分析其与患者的年龄、性别、肿瘤的部位、临床分期、病理分级、颈淋巴结转移之间的相关性。结果:口腔鳞状细胞癌中p27蛋白的阳性率63.73%明显低于正常黏膜组织92.72%(P<0.05),Skp2蛋白在口腔鳞状细胞癌中的阳性率19.02%明显高于正常黏膜组织4.24%(P<0.05)。p27蛋白阳性表达率与肿瘤的临床分期、病理分级、颈淋巴结转移呈负相关(P<0.05),Skp2蛋白阳性表达率则与以上临床病理特征呈正相关(P<0.05);二者的阳性表达率与口腔鳞状细胞癌患者的年龄、性别、肿瘤部位无关(P>0.05)。p27蛋白在口腔鳞状细胞癌中的表达与Skp2蛋白呈负相关(P<0.05)。结论:Skp2蛋白表达与靶蛋白细胞周期抑制因子p27降解相关,可能参与了口腔鳞状细胞癌的发生、发展。联合检测p27和Skp2蛋白表达有助于判断口腔鳞状细胞癌的恶性程度和预后。     

蓝芩口服液联合阿莫西林克拉维酸钾分散片治疗儿童急性扁桃体炎的效果及对细胞免疫因子的调控

目的 探讨分析蓝芩口服液联合阿莫西林克拉维酸钾分散片治疗儿童急性扁桃体炎的疗效及对患儿血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、可溶性白细胞介素-2受体(sIL-2R)水平的影响.方法 选择2017年1月-2018年7月北京市石景山区妇幼保健院收治的急性扁桃体炎患儿192例作为研究对象,将患儿随机分为...     

口腔扁平苔藓65例临床研究

目的 总结扁平苔藓（OIJP）诊断治疗经验。方法 回顾性分析本院65例OLP患者的诊疗资料。结果89．23％的患者经治疗后,症状有所缓解。结论 中西医结合治疗OLP安全有效。     

口服丙泊酚对小鼠的麻醉作用与安全性

目的研究口服丙泊酚对小鼠的麻醉作用及半数有效量(ED50)和半数致死量(LD50)。方法110只昆明小鼠随机分为三组,对照组、ED50组(内含5个亚组)及LD50组(内含5个亚组),每亚组及对照组各10只。其中ED50组和LD50组口服不同浓度丙泊酚0.2ml/10g,对照组口服生理盐水0.2ml/10g。观察小鼠翻正反射、毒性反应和死亡小鼠只数。结果口服丙泊酚ED50为208.33mg/kg,LD50为835.80mg/kg,治疗指数(TI)为4.01,ED50组麻醉起效时间为(17.45±0.38)min,作用时间为(77.96±0.87)min。结论小鼠口服丙泊酚可产生有效可逆的镇静、睡眠和麻醉作用。     

光固化复合树脂在口腔美容修复中的效果

目的 探讨在口腔美容修复患者中实施光固化复合树脂治疗的效果。方法 选取我院2021年6月- 2023年6月收治的80例口腔美容修复患者为研究对象,采用随机数字表法分为对照组和研究组,各40例。 对照组实施烤瓷冠修复,研究组实施光固化复合树脂修复,比较两组临床疗效、美观度、牙周指数、并发 症发生情况及满意度。结果 研究组总有效率为97.50%,高于对照组的77.50%（P ＜0.05）;研究组牙齿表 面光滑度、固位效果、颜色匹配及牙体形态评分高于对照组（P＜0.05）;研究组牙菌斑指数、牙周附着水 平及牙龈指数低于对照组（P ＜0.05）;研究组并发症发生率为2.50%,低于对照组的17.50%（P ＜0.05）; 研究组满意度为100.00%,高于对照组的80.00%（P＜0.05）。结论 对口腔美容修复患者实施光固化复合树 脂修复可提升修复效果,降低并发症发生率,进而提升患者满意度,值得临床应用。     

Mixed-Micellar Proliposomal Systems for Enhanced Oral Delivery of Progesterone

The objective of our study was to develop a mixed-micellar proliposomal formulation of poorly water-soluble drug progesterone and evaluate the dissolution profile and membrane transport. Several formulations of proliposomes were prepared by mixing different concentrations of lipid, progesterone, polysorbate 80, and microcrystalline cellulose. The mixed-micellar formulation of drug:dimyristoyl-phosphatidycholine:polysorbate 80 (1:20:3.3) exhibited the maximum dissolution (75.27%), while pure progesterone resulted in low dissolution. The above formulation showed a 4-fold increase in transport in Caco-2 cells and a 6-fold increase in transport across the everted rat intestinal sac experiments compared with control. Proliposomal formulations enhance the extent of dissolution and membrane transport of progesterone and serve as ideal carriers for oral delivery of drugs with low water solubility.