罗诗荣老中医学术特长与临证经验

该文全面总结了全国名老中医,国务院特殊津贴者。罗诗荣主任医师从事针灸临床五十余年的学术特长与临证经验。罗老临床诊疗重视督肾证治。善用“铺灸”疗法;针灸取穴,善用“五输”“原”穴;针灸治病,辨病辨经相得益彰;针刺施治。重视治神,得气,守气,临证治疗妙用温灸。     

Gene expression profiles during long-term memory consolidation

Changes in gene expression have been postulated to occur during long-term memory (LTM). We used high-density cDNA microarrays to assess changes in gene expression 24 h after rabbit eye blink conditioning. Paired animals were presented with a 400 ms, 1000 Hz, 82 dB tone conditioned stimulus that coterminated with a 100 ms, 60 Hz, 2 mA electrical pulse unconditioned stimulus. Unpaired animals received the same conditioned and unconditioned stimuli but presented in an explicitly unpaired manner. Differences in expression levels between paired and unpaired animals in the hippocampus and cerebellar lobule HVI, two regions activated during eye blink conditioning, indicated the involvement of novel genes as well as the participation of previously implicated genes. Patterns of gene expression were validated by in situ hybridization. Surprisingly, the data suggest that an underlying mechanism of LTM involves widespread decreased, rather than increased, gene expression. These results demonstrate the feasibility and utility of a cDNA microarray system as a tool for dissecting the molecular mechanisms of associative memory.     

Dorsal hippocampal lesions impair appetitive classical conditioning to localized cues

Three experiments examined appetitive classical conditioning in rats with small electrolytic lesions of the dorsal hippocampus. In all the experiments, the reinforcer was food delivery and the conditioned response (CR) entry to the food tray; the three experiments differed in the nature of the conditioned stimulus (CS). When this was a small light located inside the food tray, conditioning was impaired in lesioned animals, but when the CS was a general increase in illumination, they learned at the same rate as controls. With a white noise as the CS, learning was significantly faster in lesioned subjects. These data demonstrate that lesions of the dorsal hippocampus can produce impairments in appetitive delay conditioning, but only with certain types of CS. It is suggested that deficits are found with CSs that are localized in space.     

杨氏贴棉灸治疗神经性皮炎疗效观察

目的:比较杨氏贴棉灸与激素治疗神经性皮炎的疗效差异。方法:60例神经性皮炎患者,按随机数字表分为两组,治疗组用杨氏贴棉灸方法治疗,对照组用醋酸去炎松尿素软膏涂抹,治疗1周后开始观察疗效,持续治疗4周,治疗结束后进行疗效评价。结果:治疗组总有效率93.3%,对照组总有效率80.0%,两组间比较,经统计学χ2检验,差异有显著性意义(P<0.05)。结论:杨氏     

邵经明教授学术思想探讨

邵经明教授从医70多年,在疾病诊断、配穴处方、针刺手法及针灸药并用等方面,均有独到的学术见解,认为应病证结合,借鉴现代医学明确诊断;取穴应少而精,选用背俞穴治疗疑难病症常可获佳效;正确运用针刺手法,得气是取效的关键;创用热感手法、指压捻入式进针法、注射式进针法;针灸与药物并用可提高疗效,并撰写近30万字的《中医知要》。     

张家维教授治疗女性更年期综合征经验撷要

介绍张家维教授治疗女性更年期综合征的独到经验。根据女性更年期患者的生理病理特点，张老提出中医治疗更年期综合征应以补脾益肾、调和阴阳为总的治疗原则；在针灸治疗中，首先应讲究针法应用。张老根据多年的临床经验，总结了一套以“稳、准、轻、快”为特点的张氏飞针手法，同时，重视五脏背俞穴埋线治疗；此外，还提倡在治疗中应因时、因地、因人制宜，主张先针后灸，针药并用。     

论"精确处方"与"模糊处方"

药物与药物合用之后可能发生的关系,称为"药际关系",这种关系是客观存在,而配伍则具有主观性。要使配伍的主观愿望得以实现,必须使药物符合"好的药际关系"。经方、时方产生的根源正在于是否符合"特别好的药际关系"。在此基础上,可由含糊的经方、时方的概念,推出"精确处方"与"模糊处方"的新概念。由此,方剂大致可区分为两大类,这样的区分,使方剂学教学和方剂学研究今后可以向着两个不同的方向发展,而临床运用方剂也可以按不同的思路进行。     

NET ABSORPTION OF STARCH IN LOW BIRTH WEIGHT INFANTS

Abstract. Senterre, J. (Department of Paediatrics, University Hospital, Liège, Belgium). Net absorption of starch in low birth weight infants. Ada Paediatr Scand, 69: 653, 1980. —Twelve 3-day metabolic balance studies were carried out in 12 low birth weight infants fed an infant formula providing 3.5 g of corn starch per kilogram body weight per day. The mean coefficients of net absorption were 88±6% for starch, 70±14% for fat and 90±4% for nitrogen. No relationship was found between starch absorption and nitrogen or fat absorption. There was no relationship between starch absorption and the duration of starch feeding. It is concluded that the ability of young infants to digest large quantities of starch is most likely limited resulting from low pancreatic alpha-amylase activity. Nevertheless, from a practical point of view, small amounts of starch in infant formulas can be considered not only as a thickener but also as a source of calories.     

BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin’s lymphoma from primary mediastinal large B‐cell lymphoma

Hoeller S, Zihler D, Zlobec I, Obermann EC, Pileri SA, Dirnhofer S & Tzankov A
(2010) Histopathology 56, 217–228 BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin’s lymphoma from primary mediastinal large B‐cell lymphoma Aims: To clarify which immunohistochemical markers could be helpful in distinguishing between classical Hodgkin’s lymphoma (cHL) and primary mediastinal B‐cell lymphoma (PMBCL) to more narrowly define ‘B‐cell lymphoma, unclassifiable, with features intermediate between diffuse large B‐cell lymphoma and cHL’. Methods and results: Two hundred and 83 cHLs and 51 PMBCLs were analysed on validated tissue microarray platforms with antibodies to BOB.1, CD15, CD20, CD23, CD30, CD79a, cyclin E, LMP‐1, MUM1p, p63 and Oct2. The marker cut‐off scores were calculated using receiver–operating characteristic curves. Markers with the highest positive predictive value for cHL were: CD15, cyclin E, LMP‐1 (all 100%), MUM1p (93%) and CD30 (83%). High sensitivity was achieved only by CD30 (92%) and cyclin E (79%). Nineteen percent of PMBCLs were also positive for CD30, which led to a lower specificity of CD30 as regards cHL (81%) compared with cyclin E (100%). The antibodies with the highest positive predictive value for PMBCL were: CD23 (98%), p63 (96%), BOB.1 (94%) and CD79a (90%), with high sensitivity for BOB.1 (100%), CD79a (89%) and p63 (82%). Conclusions: The use of at least three of the most accurate immunohistochemical markers, cyclin E, CD79a and BOB.1, may be helpful in the differential diagnosis of cHL and PMBCL.