全文获取类型
收费全文 | 20451篇 |
免费 | 2434篇 |
国内免费 | 660篇 |
专业分类
耳鼻咽喉 | 153篇 |
儿科学 | 261篇 |
妇产科学 | 334篇 |
基础医学 | 4086篇 |
口腔科学 | 1099篇 |
临床医学 | 1662篇 |
内科学 | 3991篇 |
皮肤病学 | 439篇 |
神经病学 | 1590篇 |
特种医学 | 292篇 |
外国民族医学 | 1篇 |
外科学 | 1519篇 |
综合类 | 1767篇 |
现状与发展 | 7篇 |
预防医学 | 1134篇 |
眼科学 | 683篇 |
药学 | 2866篇 |
7篇 | |
中国医学 | 1056篇 |
肿瘤学 | 598篇 |
出版年
2024年 | 93篇 |
2023年 | 516篇 |
2022年 | 915篇 |
2021年 | 1295篇 |
2020年 | 1035篇 |
2019年 | 1028篇 |
2018年 | 981篇 |
2017年 | 1020篇 |
2016年 | 1043篇 |
2015年 | 1116篇 |
2014年 | 1304篇 |
2013年 | 2393篇 |
2012年 | 1044篇 |
2011年 | 1142篇 |
2010年 | 981篇 |
2009年 | 950篇 |
2008年 | 924篇 |
2007年 | 914篇 |
2006年 | 811篇 |
2005年 | 651篇 |
2004年 | 598篇 |
2003年 | 446篇 |
2002年 | 394篇 |
2001年 | 293篇 |
2000年 | 224篇 |
1999年 | 224篇 |
1998年 | 189篇 |
1997年 | 139篇 |
1996年 | 140篇 |
1995年 | 113篇 |
1994年 | 79篇 |
1993年 | 100篇 |
1992年 | 62篇 |
1991年 | 49篇 |
1990年 | 30篇 |
1989年 | 32篇 |
1988年 | 38篇 |
1987年 | 27篇 |
1986年 | 23篇 |
1985年 | 30篇 |
1984年 | 35篇 |
1983年 | 25篇 |
1982年 | 17篇 |
1981年 | 23篇 |
1980年 | 16篇 |
1979年 | 12篇 |
1978年 | 11篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1975年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Eros S. Chaves Robert C. Wood Archie A. Jones Dewey A. Newbold Mary A. Manwell Kenneth S. Kornman 《Journal of clinical periodontology》1993,20(2):139-143
Abstract Bleeding on probing (BOP) and the gingival index have been used to clinically characterize the degree of gingival inflammation. It is, however, unclear to what extent these parameters correlate to each other and to probing pocket depth (PD). The purpose of this clinical study was to evaluate the association between BOP and GI bleeding (scores of 2 and 3), as well as the relationship of these variables to PD, in a group of patients presenting with naturally-occurring gingivitis. Based on screening examinations of 125 subjects with at least 20 teeth, no more than 4 sites with PD over 6 mm, a BOP frequency of 30% or greater, and no systemic condition that would influence the inflammatory response, were selected. 2 weeks after screening they were examined at 6 sites per tooth for plaque index, GI, PD and BOP. A standardized pressure sensitive probe (Florida Probe) with 20 g probing force was used for BOP and PD measurements. In this population, means of 40.9% (S.E.= 1.36) BOP sites and 35.3% (S.E, = 1.81) GI bleeding sites per patient were found. A total of 20,008 sites ranging in PD up to 5.9 mm were evaluated; however, the majority of sites (19,723, 98.6%) presented with <4 mm PD. When sites were evaluated, BOP demonstrated a positive correlation with PD, whereas GI bleeding correlated with PH. For sites characterized by the absence of BOP as well as the absence of GI bleeding (scores 0 and 1), the highest % of agreement between the 2 indices (77.7%) was found in shallow sites (0.1–2 mm). In contrast, when sites presenting with both BOP and GI bleeding were analyzed, the highest % of agreement (85,4%) was found for sites with PD >4.0 mm. In this gingivitis population group, it appears that BOP and GI bleeding evaluate distinct inflammatory1 conditions of the gingival tissues, and the relationship between the 2 clinical parameters may vary according to PD at the individual site examined. 相似文献
12.
13.
14.
n. holmén † s. isaksson † m. simrén h. sjövall & l. öhman † 《Neurogastroenterology and motility》2007,19(2):119-125
15.
16.
17.
Endotoxin-induced uveitis (EIU) in the rat: A study of inflammatory and immunological mechanisms 总被引:2,自引:0,他引:2
Endotoxin-induced uveitis (EIU) can be produced by systemic injection of endotoxin (ET). It is not clear yet why exclusive ocular involvement occurs in this model. To clarify this question and to establish the sequence of inflammatory events, EIU was induced in Lewis rats by footpad injection of Salmonella ET. Ocular inflammatory response (anterior chamber cells and proteins), aqueous inflammation mediators (thromboxane B2, prostaglandin E2, leukotriene B4 and substance P) and MHC class 2 (Ia) antigen expression in the ciliary body were monitored for 72 hours. Thromboxane B2 was detected early in the aqueous humor, peaking already 1 hour after ET injection. Prostaglandin E2 & leukotriene B4 peaks and a second peak of thromboxane B2 were recorded 18 hours after ET-injection, at the time of maximal ocular inflammation. MHC-class 2 expression was first detected in the ciliary body stroma at the vascular level 6 hours after ET injection and was massively expressed in the ciliary body epithelium at 18 and 72 hours. It is hypothetized that ciliary body endothelium is particularly sensitive to the effect of ET and is the site of thrombocyte adherence. Vascular damage leads in succession to cellular infiltration, release of inflammation mediators and disruption of blood-ocular barrier. MHC-class 2 expression is a secondary phenomenon and is probably at the origin of additional tissue damage from immune effector mechanisms. 相似文献
18.
The influence of anaesthetic techniques and type of delivery on peripartum serum interleukin-6 concentrations 总被引:2,自引:0,他引:2
R. F. DE JONGH E. P. BOSMANS M. J. PUYLAERT W. U. OMBELET H. J. VANDEPUT R. A. BERGHMANS M. MAES R. J. HEYLEN 《Acta anaesthesiologica Scandinavica》1997,41(7):853-860
Background: Interleukin-6 is a pleiotropic cytokine with a wide range of physiological activities. It plays an important role in the immuno-neuro-humoral axis during stress and surgery.
Methods: Serum interleukin-6 in parturients was measured on hospital admission, immediately after birth and 12 and 24 hours later. All parturients had uncomplicated pregnancies, and delivered vaginally without (n=31) or with (n=20) epidural analgesia, or underwent Caesarean section under epidural (n=20) or general (n=10) anaesthesia.
Results: Serum interleukin-6 assayed immediately following Caesarean section was low, but peaked 12 hours later, irrespective of the anaesthetic technique or other foetomaternal characteristics. Patients who delivered vaginally showed the highest interleukin-6 levels immediately after delivery. These were positively correlated with serum interleukin-6 on admission and duration of labour. Serum interleukin-6 was significantly higher in parturients who had epidural analgesia, and was significantly lower in those receiving intravaginal prostaglandins compared to those without prostaglandins.
Conclusion: The interleukin-6 response after Caesarean section can be explained by a generalized acute phase response to surgery, with no anaesthetic, maternal or neonatal interference. The rapid increase in peripartum serum interleukin-6 levels after vaginal delivery reflects, in part, cervical ripening or labour, their physiological triggers and psychological or physical stress. Regional anaesthesia, duration of labour and exogenous prostaglandin administration can modulate the peripartum interleukin-6 response and subsequently the physiological effects of this cytokine. 相似文献
Methods: Serum interleukin-6 in parturients was measured on hospital admission, immediately after birth and 12 and 24 hours later. All parturients had uncomplicated pregnancies, and delivered vaginally without (n=31) or with (n=20) epidural analgesia, or underwent Caesarean section under epidural (n=20) or general (n=10) anaesthesia.
Results: Serum interleukin-6 assayed immediately following Caesarean section was low, but peaked 12 hours later, irrespective of the anaesthetic technique or other foetomaternal characteristics. Patients who delivered vaginally showed the highest interleukin-6 levels immediately after delivery. These were positively correlated with serum interleukin-6 on admission and duration of labour. Serum interleukin-6 was significantly higher in parturients who had epidural analgesia, and was significantly lower in those receiving intravaginal prostaglandins compared to those without prostaglandins.
Conclusion: The interleukin-6 response after Caesarean section can be explained by a generalized acute phase response to surgery, with no anaesthetic, maternal or neonatal interference. The rapid increase in peripartum serum interleukin-6 levels after vaginal delivery reflects, in part, cervical ripening or labour, their physiological triggers and psychological or physical stress. Regional anaesthesia, duration of labour and exogenous prostaglandin administration can modulate the peripartum interleukin-6 response and subsequently the physiological effects of this cytokine. 相似文献
19.
20.