Breast Augmentation with Autologous Fat Grafting Immediately after Removal of Polyacrylamide Hydrogel and Fibrotic Capsule in 162 Patients

ObjectiveIn this study, we investigated the feasibility and efficacy of immediate breast augmentation with autologous fat grafting after removal of polyacrylamide hydrogel (PAAG) and fibrotic capsule.MethodsA retrospective study was conducted on 162 female patients who underwent removal of breast filler PAAG and the fibrotic capsule which produced after injection of PAAG via areola omega-shaped incision. Then autologous fat grafting was immediately performed evenly and radially around the areola via the same incision into different layers (subcutaneous, submammary tissue, pectoralis major intramuscular, and inferior pectoralis major space) except the empty cavity. The cavity left by removal of PAAG and fibrous capsule was closed with negative pressure drainage tube and slight external pressure.ResultsAll patients recovered well without severe complications. The average score of postoperative satisfaction with physical well-being: chest was 99.83 (total score: 100) compared with the average satisfaction score of 71.69 (total score: 100) preoperatively by means of BREAST-Q™ evaluation (p < 0.01). All patients were satisfied with their postoperative breast shape.ConclusionsRemoving as much as possible is critical for patients who underwent the PAAG injection. Our experience in immediate breast augmentation with autologous fat grafting after removal of PAAG and fibrotic capsule proved useful and effective to maintain the balance between removing the PAAG as much as possible and retaining soft tissue to reshape breasts.Level of EvidenceIV.     

疏风解毒胶囊联合抗生素治疗CAP的疗效及安全性评价

目的 对疏风解毒胶囊联合抗生素治疗社区获得性肺炎(CAP)的临床疗效进行探讨,同时观察此种治疗方法 的不良反应,评价其安全性.方法 采取随机数字表法将2017年5月～2020年5月收治的120例CAP患者分为单药组与联合组,每组各60例,单药组给予莫西沙星静脉滴注治疗,联合组在单药组基础上加用疏风解毒胶囊治疗,对比两组...     

The role of Tenonplasty in the management of limbal and scleral ischemia due to acute ocular chemical burns

Of the various manifestations of ocular chemical burns (OCBs), ischemia of the limbus and the peri-limbal sclera indicates poor prognosis and in severe cases threaten the integrity of the globe. Tenonplasty is a surgical procedure which involves advancing the Tenon’s capsule over the ischemic areas to provide a vascular supply and to enable migration of the conjunctival epithelium. This review aims to provide an overview of the diagnosis of limbal ischemia and its management with Tenonplasty. A literature review was conducted using the keywords “Tenonplasty,” “Tenon’s capsule,” “ocular chemical injury,” “ocular thermal injury,” “Tenon advancement,” “scleral ischemia,” and “limbal ischemia,” and outcomes were studied from seven selected articles. In addition to clinical evaluation, in vivo imaging techniques such as anterior segment optical coherence tomography angiography can provide an objective method of measuring and monitoring the ischemia and re-perfusion of the peri-limbal vasculature. Tenonplasty can be performed in eyes with acute OCBs with scleral or limbal ischemia by dissecting the Tenon’s layer from the orbit and securing it to the limbus. The indications, mechanism of action, peri-operative considerations, surgical technique, and post-operative care of Tenonplasty are discussed in detail. The average time for post-operative re-epithelization ranges from 1 to 6 months with the formation of a symblepharon being the most common complication. In conclusion, Tenonplasty is a globe-salvaging procedure in cases with severe limbal and scleral ischemia because of OCBs and has good anatomical outcomes priming the globe for subsequent re-constructive and vision-restoring surgeries.     

高效液相色谱法测定复方胆通胶囊中羟甲香豆素的含量

目的:用高效液相色谱法测定复方胆通胶囊中羟甲香豆素的含量.方法:高效液相色谱法,采用SWG(200 mm×4.6 mm,5 μm)柱,以萘为内标,甲醇-水(3:1)为流动相,流速为1.00 mL·min-1, 检测波长为252 nm.结果:羟甲香豆素在17～68 μg·mL-1浓度范围内呈线性关系(r=0.999 9,n=7).该法回收率99.4%,RSD为0.05%(n=5).结论:该方法简单、快速、准确.     

手术联合药物对下生殖道多部位高度病变患者安全性的影响

目的 探讨宫颈环形电切术联合重组人干扰素a2b阴道泡腾胶囊在下生殖道多部位高度病变中的疗效及安全性。方法 选择2018年1月—2020年1月下生殖道多部位高度病变患者80例,随机数字表法分为两组。对照组40例给予宫颈环形电切术干预,观察组则在手术基础上联合重组人干扰素a2b阴道泡腾胶囊,治疗后2周评估患者效果并完成12个月随访,比较两组炎性因子水平、T淋巴细胞水平、并发症及复发率。结果 观察组治疗后2周白细胞介素-10(interleukin-10,IL-10)水平高于对照组,差异有统计学意义(P <0.05);C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)低于对照组,差异有统计学意义(P <0.05);观察组干预2周后CD3⁺、CD4⁺、CD4⁺/CD8⁺高于对照组,差异有统计学意义(P<0.05);CD8⁺低于对照组,差异有统计学意义(P <0.05);两组治...     

KZY-2复方制剂对小鼠吞噬细胞吞噬功能的影响

目的：探讨知母等抗真菌中药有效组分复方制剂（KZY-2）的免疫药理作用。方法：（1）采用BALB／c小鼠体内吞噬实验法,设立对照组与试验组,对比观察试验组与对照组小鼠中性粒细胞对白假丝酵母菌标准菌株（ATCC 14053、CCCM Cla）和临床分离菌株（Cl-1、Cl-2、Cl-3、Cl-4）的吞噬百分数及吞噬指数。（2）将不同浓度的药物分别注射至小鼠腹腔,观察药物浓度对吞噬细胞吞噬功能的影响。结果：（1）低浓度药物作用结果：①吞噬百分数均值及P值：对ATCC 14053、CCCM C1a、Cl-1、Cl-2、Cl-3、Cl-4依次为：75．1％、P〈0．01,67．9％、P〈0．01,54．8％、P〈0．05,52．6％、P〈0．05,66．3％、P〈0．05;43．6％、P〉0．05。②吞噬指数均值及P值：依次为2．03、P〈0．01,1．53、P〈0．01;0．873、P〉0．05,0．783、P〉0．05 0．505、P〉0．05,0．356、P〉0．05。（2）高浓度药物作用结果：①吞噬百分数均值及P值：对ATCC 14053、Cl-4依次为：83．21％、P〈0．01：66．5％、P〈0．05。②吞噬指数均值及P值：对ATCC 14053、Cl-4依次为：2．11、P〈0．01;1．23、P〈0．05。结论：KZY-2复方制剂具有明显增强小鼠中性粒细胞对白假丝酵母菌的吞噬作用,吞噬细胞对实验菌吞噬作用的强弱与药物浓度有关。     

中西医结合治疗糖尿病周围血管病变临床观察

目的观察复荣通脉胶囊联合贝前列腺素钠治疗糖尿病周围血管病变的临床疗效。方法将入选的糖尿病周围血管病变患者60例,随机分为治疗组30例和对照组30例,两组均常规治疗。治疗组给予复荣通脉胶囊口服联合贝前列腺素钠片口服,对照组单用贝前列腺素钠片口服,观察两组临床症状、皮温、ABI的变化。结果治疗组在改善临床症状、皮温、ABI等方面明显优于对照组(P0.05,P0.01),且未见明显不良反应。结论复荣通脉胶囊联合贝前列腺素钠片治疗糖尿病周围血管病变,疗效优于单用贝前列腺素钠片。     

抗痛风胶囊对急性痛风性关节炎的作用及下调关节软骨组织MMP-1蛋白表达

目的:观察抗痛风胶囊对大鼠急性痛风性关节炎(AGA)的治疗作用及对软骨组织基质金属蛋白酶-1(MMP-1)蛋白表达的影响。方法:大鼠足踝关节注射尿酸钠悬液诱导AGA,容积法检测踝关节肿胀程度,HE染色观察关节软骨组织的病理组织学变化,免疫组织化学染色及图像分析检测关节软骨内MMP-1蛋白表达。结果:抗痛风胶囊0.3 mg/kg和1.2 mg/kg连续灌胃给药5d,明显减小AGA大鼠足容积,第5d关节肿胀抑制率高达70%～90%。HE染色后显微镜下观察,可见模型组大鼠足踝关节软骨组织细胞排列紊乱、出现充血、肿胀和关节表面的破坏,抗痛风胶囊治疗后,明显改善其病理组织学变化。免疫组织化学检测可见,与模型组比较,抗痛风胶囊和秋水仙碱(0.8mg/kg)均明显下调软骨细胞MMP-1蛋白的表达,其平均光密度值明显降低。结论:抗痛风胶囊对AGA具有明显治疗作用,且降低AGA大鼠关节软骨组织MMP-1蛋白表达可能该药缓解关节炎症肿胀的主要作用机制之一。     

脉血康胶囊治疗冠心病心绞痛的 Meta 分析

目的：系统评价脉血康胶囊治疗冠心病心绞痛的疗效。方法检索Cochrane Central Register of Controlled Trials（CENTRAL,2012年2月第二期）、PUBMED、中国生物医学文献数据库、万方期刊论文数据库、维普期刊资源整合服务平台、中国学术期刊网络出版总库,时间均为建库至2013年12月,纳入符合标准的临床随机对照试验,并进行纳入研究的参考文献以及心血管相关杂志及会议报告的人工检索。经过文献筛选,对符合标准的临床随机对照试验进行Meta分析。结果最终纳入9项研究,包括577例冠心病患者。9项研究都对脉血康胶囊治疗冠心病进行了临床疗效分析,其总OR值为4.69,95%CI为（3.27,6.72）,P﹤0.00001;3项对心电图有效改变进行了分析,其总OR值为1.83,95%CI为（1.15,2.92）,P=0.01。结论脉血康胶囊对冠心病能产生较好的临床疗效,并且能有效改善心电图。     

益气化湿胶囊干预腺嘌呤诱导大鼠高尿酸血症肾损伤的研究

目的:探讨益气化湿胶囊对腺嘌呤诱导大鼠高尿酸血症、肾损伤的防治作用。方法:利用腺嘌呤灌胃法诱导Wistar大鼠制备高尿酸血症和肾损伤模型,益气化湿胶囊预防治疗3周,测定与高尿酸血症和肾衰相关的各项组织器官和血液生化指标。结果:益气化湿胶囊可显著降低血清尿酸水平,与别嘌呤醇的降尿酸效果相当;并能显著降低尿酸氮、肌酐、丙二醛水平。结论:益气化湿胶囊有干预腺嘌呤诱导高尿酸血症和肾损伤的作用。