全文获取类型
收费全文 | 176507篇 |
免费 | 4041篇 |
国内免费 | 2182篇 |
专业分类
耳鼻咽喉 | 1750篇 |
儿科学 | 6449篇 |
妇产科学 | 2885篇 |
基础医学 | 21744篇 |
口腔科学 | 4378篇 |
临床医学 | 11505篇 |
内科学 | 34073篇 |
皮肤病学 | 3183篇 |
神经病学 | 10561篇 |
特种医学 | 3443篇 |
外国民族医学 | 6篇 |
外科学 | 26617篇 |
综合类 | 11126篇 |
一般理论 | 4篇 |
预防医学 | 9850篇 |
眼科学 | 3372篇 |
药学 | 19127篇 |
11篇 | |
中国医学 | 6748篇 |
肿瘤学 | 5898篇 |
出版年
2022年 | 1407篇 |
2021年 | 2519篇 |
2020年 | 1343篇 |
2019年 | 12952篇 |
2018年 | 12563篇 |
2017年 | 5743篇 |
2016年 | 1357篇 |
2015年 | 1414篇 |
2014年 | 3143篇 |
2013年 | 4986篇 |
2012年 | 3247篇 |
2011年 | 3392篇 |
2010年 | 2890篇 |
2009年 | 2912篇 |
2008年 | 3365篇 |
2007年 | 4495篇 |
2006年 | 4728篇 |
2005年 | 4566篇 |
2004年 | 3688篇 |
2003年 | 3714篇 |
2002年 | 3533篇 |
2001年 | 3494篇 |
2000年 | 3609篇 |
1999年 | 3267篇 |
1998年 | 3301篇 |
1997年 | 2642篇 |
1996年 | 2457篇 |
1995年 | 2796篇 |
1994年 | 2561篇 |
1993年 | 1983篇 |
1992年 | 1595篇 |
1991年 | 1579篇 |
1990年 | 1310篇 |
1989年 | 1034篇 |
1988年 | 1074篇 |
1987年 | 1033篇 |
1986年 | 871篇 |
1985年 | 5470篇 |
1984年 | 7326篇 |
1983年 | 5868篇 |
1982年 | 6311篇 |
1981年 | 5748篇 |
1980年 | 4923篇 |
1979年 | 4989篇 |
1978年 | 4086篇 |
1977年 | 3057篇 |
1976年 | 3531篇 |
1975年 | 2741篇 |
1974年 | 2524篇 |
1973年 | 2230篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
92.
Granat Nadav Klang Eyal Tau Noam Kleinbaum Yeruham 《The American journal of emergency medicine》2019,37(10):1823-1828
ObjectiveTo evaluate the significance of sonographic perinephric fluid collection on the emergent management of patients with acute urinary stone obstruction.MethodsWe conducted a prospective study with retrospective analysis. Since January 2016 through July 2017, patients admitted to our tertiary hospital's emergency department (ED) with suspected symptomatic urinary stones underwent ultrasound evaluation. Images were prospectively interpreted by experienced radiologist who analyzed each case for the following imaging features: hydronephrosis, perinephric fluid and urethral stone identification. The presence and measurements of perinephric fluid were re-evaluated by second radiologist who was blinded for the first reader's measurements. Retrospective analysis was conducted to evaluate for an association between perinephric fluid collection and the following outcome variables: need for analgesics, the number of doses of analgesics and the amount of morphine (mg) in the ED, elevation of creatinine levels, hospitalization and need for urological interventions.ResultsThe need for analgesics, the number of doses of analgesics and the amount of morphine were significantly associated with the presence of perinephric fluid (p < 0.05). The odds ratio for the need for analgesics was 3.8 in the presence of any perinephric fluid, and 8.9 in the presence of moderate/severe perinephric fluid. No other patient outcome variables were found to be significantly associated with the presence of perinephric fluid (p > 0.05).ConclusionsThis study shows a correlation between sonographic evidence of perinephric fluid and more severe pain. Therefore, an emergency physician can consider the evidence of perinephric fluid, in acute urethral stone obstruction, a predictor for more severe pain. 相似文献
93.
Marta López-Fauqued Laura Campora Frédérique Delannois Mohamed El Idrissi Lidia Oostvogels Ferdinandus J. De Looze Javier Diez-Domingo Thomas C. Heineman Himal Lal Janet E. McElhaney Shelly A. McNeil Wilfred Yeo Fernanda Tavares-Da-Silva 《Vaccine》2019,37(18):2482-2493
Background
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.Methods
Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Safety analyses were performed on the pooled total vaccinated cohort, consisting of participants receiving at least one dose of RZV or placebo. Solicited and unsolicited adverse events (AEs) were collected for 7 and 30?days after each vaccination, respectively. Serious AEs (SAEs) were collected from the first vaccination until 12?months post-last dose. Fatal AEs, vaccination-related SAEs, and potential immune-mediated diseases (pIMDs) were collected during the entire study period.Results
Safety was evaluated in 14,645 RZV and 14,660 placebo recipients. More RZV than placebo recipients reported unsolicited AEs (50.5% versus 32.0%); the difference was driven by transient injection site and solicited systemic reactions that were generally seen in the first week post-vaccination. The occurrence of overall SAEs (RZV: 10.1%; Placebo: 10.4%), fatal AEs (RZV: 4.3%; Placebo: 4.6%), and pIMDs (RZV: 1.2%; Placebo: 1.4%) was balanced between groups. The occurrence of possible exacerbations of pIMDs was rare and similar between groups. Overall, except for the expected local and systemic symptoms, the safety results were comparable between the RZV and Placebo groups irrespective of participant age, gender, or race.Conclusions
No safety concerns arose, supporting the favorable benefit-risk profile of RZV. 相似文献94.
Understanding why persons with human immunodeficiency virus (HIV) have accelerated atherosclerosis and its sequelae, including coronary artery disease (CAD) and myocardial infarction, is necessary to provide appropriate care to a large and aging population with HIV. In this review, we delineate the diverse pathophysiologies underlying HIV-associated CAD and discuss how these are implicated in the clinical manifestations of CAD among persons with HIV. Several factors contribute to HIV-associated CAD, with chronic inflammation and immune activation likely representing the primary drivers. Increased monocyte activation, inflammation, and hyperlipidemia present in chronic HIV infection also mirror the pathophysiology of plaque rupture. Furthermore, mechanisms central to plaque erosion, such as activation of toll-like receptor 2 and formation of neutrophil extracellular traps, are also abundant in HIV. In addition to inflammation and immune activation in general, persons with HIV have a higher prevalence than uninfected persons of traditional cardiovascular risk factors, including dyslipidemia, hypertension, insulin resistance, and tobacco use. Antiretroviral therapies, although clearly necessary for HIV treatment and survival, have had varied effects on CAD, but newer generation regimens have reduced cardiovascular toxicities. From a clinical standpoint, this mix of risk factors is implicated in earlier CAD among persons with HIV than uninfected persons; whether the distribution and underlying plaque content of CAD for persons with HIV differs considerably from uninfected persons has not been definitively studied. Furthermore, the role of cardiovascular risk estimators in HIV remains unclear, as does the role of traditional and emerging therapies; no trials of CAD therapies powered to detect clinical events have been completed among persons with HIV. 相似文献
95.
96.
97.
98.
99.
Although hepatitis E virus (HEV) is the primary cause of enterically transmitted acute hepatitis and jaundice in developing countries, locally acquired HEV infections are increasing in nonendemic countries. As such, HEV is emerging as an underdiagnosed cause of infection. This report describes three clinically variable cases of HEV infection with unusual clinical presentations. These cases highlight the fact that HEV should be considered in the differential diagnosis of patients with unexplained hepatitis (acute or chronic) with or without extrahepatic manifestations. HEV should also be considered in patients with persistently elevated liver enzymes who have not travelled to known HEV-endemic regions. Lack of knowledge among physicians and an absence of standardized diagnostic tests may result in increased morbidity and mortality from HEV infection. 相似文献
100.