全文获取类型
收费全文 | 494155篇 |
免费 | 37431篇 |
国内免费 | 10699篇 |
专业分类
耳鼻咽喉 | 6666篇 |
儿科学 | 12470篇 |
妇产科学 | 8680篇 |
基础医学 | 39900篇 |
口腔科学 | 13248篇 |
临床医学 | 51860篇 |
内科学 | 56205篇 |
皮肤病学 | 6406篇 |
神经病学 | 27042篇 |
特种医学 | 12319篇 |
外国民族医学 | 40篇 |
外科学 | 51711篇 |
综合类 | 76447篇 |
现状与发展 | 19篇 |
一般理论 | 52篇 |
预防医学 | 56956篇 |
眼科学 | 6609篇 |
药学 | 46224篇 |
631篇 | |
中国医学 | 47976篇 |
肿瘤学 | 20824篇 |
出版年
2023年 | 8311篇 |
2022年 | 13477篇 |
2021年 | 20896篇 |
2020年 | 19989篇 |
2019年 | 24440篇 |
2018年 | 21995篇 |
2017年 | 18911篇 |
2016年 | 16403篇 |
2015年 | 15459篇 |
2014年 | 31030篇 |
2013年 | 32689篇 |
2012年 | 28135篇 |
2011年 | 30364篇 |
2010年 | 24474篇 |
2009年 | 22070篇 |
2008年 | 21123篇 |
2007年 | 21575篇 |
2006年 | 18736篇 |
2005年 | 16142篇 |
2004年 | 13236篇 |
2003年 | 11594篇 |
2002年 | 9114篇 |
2001年 | 7990篇 |
2000年 | 6740篇 |
1999年 | 5726篇 |
1998年 | 4682篇 |
1997年 | 4387篇 |
1996年 | 3741篇 |
1995年 | 3568篇 |
1994年 | 3369篇 |
1993年 | 2783篇 |
1992年 | 2725篇 |
1991年 | 2388篇 |
1990年 | 2121篇 |
1989年 | 1941篇 |
1988年 | 1831篇 |
1987年 | 1597篇 |
1986年 | 1488篇 |
1985年 | 4708篇 |
1984年 | 5757篇 |
1983年 | 4058篇 |
1982年 | 4760篇 |
1981年 | 4127篇 |
1980年 | 3661篇 |
1979年 | 3365篇 |
1978年 | 2885篇 |
1977年 | 2185篇 |
1976年 | 2488篇 |
1975年 | 1838篇 |
1974年 | 1609篇 |
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
991.
Robert M. Levy Roman Saikovsky Evgeniya Shmidt Alexander Khokhlov Bruce P. Burnett 《Nutrition Research》2009
Flavocoxid (Limbrel), a proprietary mixture of flavonoid molecules (baicalin and catechin), was tested against a traditional nonsteroidal anti-inflammatory drug, naproxen, for the management of the signs and symptoms of moderate osteoarthritis (OA) in humans. Discomfort and global disease activity were used as the primary end points, and safety assessments were also taken for both treatments as a secondary endpoint. In this double-blind study, 103 subjects were randomly assigned to receive either flavocoxid [500 mg twice daily (BID)] or naproxen (500 mg BID) in a 1-month onset of action trial. Outcome measures included the short Western Ontario and McMaster University Osteoarthritis Index, subject Visual Analogue Scale for discomfort and global response, and investigator Visual Analogue Scale for global response and fecal occult blood. Both flavocoxid and naproxen showed significant reduction in the signs and symptoms of knee OA (P ≤ .001). There were no statistically detectable differences between the flavocoxid and naproxen groups with respect to any of the outcome variables. Similarly, there were no statistically detectable differences between the groups with respect to any adverse event, although there was a trend toward a higher incidence of edema and nonspecific musculoskeletal discomfort in the naproxen group. In this short-term pilot study, flavocoxid was as effective as naproxen in controlling the signs and symptoms of OA of the knee and would present a safe and effective option for those individuals on traditional nonsteroidal anti-inflammatory drugs or cyclooxygenase-2 inhibitors. A low incidence of adverse events was reported for both groups. 相似文献
992.
993.
M. Mizuguchi H. Yamanouchi T. Ichiyama M. Shiomi 《Acta neurologica Scandinavica》2007,115(S186):45-56
Acute encephalopathy is the most serious complication of pediatric viral infections, such as influenza and exanthem subitum. It occurs worldwide, but is most prevalent in East Asia, and every year several hundreds of Japanese children are affected by influenza-associated encephalopathy. Mortality has recently declined, but is still high. Many survivors are left with motor and intellectual disabilities, and some with epilepsy. This article reviews various syndromes of acute encephalopathy by classifying them into three major categories. The first group caused by metabolic derangement consists of various inherited metabolic disorders and the classical Reye syndrome. Salicylate is a risk factor of the latter condition. The second group, characterized by a systemic cytokine storm and vasogenic brain edema, includes Reye-like syndrome, hemorrhagic shock and encephalopathy syndrome, and acute necrotizing encephalopathy. Non-steroidal anti-inflammatory drugs, such as diclofenac sodium and mephenamic acid, may aggravate these syndromes. Severe cases are complicated by multiple organ failure and disseminated intravascular coagulation. Mortality is high, although methylprednisolone pulse therapy may be beneficial in some cases. The third group, characterized by localized edema of the cerebral cortex, has recently been termed acute encephalopathy with febrile convulsive status epilepticus, and includes hemiconvulsion-hemiplegia syndrome and acute infantile encephalopathy predominantly affecting the frontal lobes. Theophylline is a risk factor of these syndromes. The pathogenesis is yet to be clarified, but an increasing body of evidence points to excitotoxicity and delayed neuronal death. 相似文献
994.
日本急救医疗体系比较发达,一般把急救患者分检为I级、II级和III级,再送到相应的医疗机构进行救治。急救医疗从业人员都是专业的人员,能够及时有效地对急救患者进行诊治。现在日本正在进行急救医疗体系的改革,成立了相关委员会并形成一些基础改革,主要是增加急救医疗的投入及专业急救医生的提高。这些对我国急救医疗体系现存的一些问题有一定借鉴意义。 相似文献
995.
医疗行为的特殊性,决定了医患双方在医学信息方面的不对称性和医者拥有一定的自由裁量权,因此,医者作为医疗服务的主体,如何增强自律意识,直接关系到诚信的树立及和谐的互动式医患关系的建立和发展。 相似文献
996.
997.
生化汤源流及后世应用考 总被引:1,自引:0,他引:1
阐述生化汤源流及其功用 ,对傅氏活用生化汤的经验做了简要分析 ,从以病论方、以证论方、以药论方三方面总结现代应用生化汤的状况 ,初步探索生化汤的临床应用规律。 相似文献
998.
扩髓交锁髓内钉治疗股骨、胫骨干骨折 总被引:7,自引:2,他引:5
目的探讨交锁髓内钉治疗股骨、胫骨干骨折的临床效果.方法应用交锁髓内钉治疗不同类型的股骨干骨折18例,胫骨干骨折15例.结果33例患者随访8~24个月,平均15.2个月,33例均骨性愈合.未出观畸性愈合、再骨折、断钉及膝、踝关节僵硬等并发症.结论交锁髓内钉治疗股骨、胫骨干骨折治愈率高,并发症少,效果满意. 相似文献
999.
清开灵注射液治疗脑血管性痴呆32例 总被引:9,自引:0,他引:9
目的观察清开灵注射液治疗脑血管性痴呆的疗效.方法将中医学辨证属于实证的64例脑血管性痴呆患者随机分为治疗组(清开灵注射液组)和对照组(脑复康组),治疗5周后,将两组治疗前后在智力障碍程度、肢体功能、血液流变学指标、中医证型疗效方面的变化进行比较.结果经治疗后治疗组和对照组相比较,智力障碍程度变化(有效率、MMSE、ADL积分)、肌力、步行能力改变有显著性差异,p<0.05.而治疗前后组内及组间血流变指标虽有一定下降,但无统计学意义(p>0.05).结论清开灵注射液对脑血管性痴呆患者,在改善智力障碍、肌力、步行能力方面有较好的疗效. 相似文献
1000.
益气活血方对气虚血瘀证脑缺血再灌注损伤大鼠Fas、FasL蛋白表达的影响 总被引:1,自引:0,他引:1
目的:探讨益气活血方对气虚血瘀证局灶性脑缺血再灌注损伤大鼠Fas、FasL蛋白表达的影响。方法:采用气虚血瘀证局灶性脑缺血再灌注损伤大鼠模型,用线栓法阻塞大鼠大脑中动脉复制局部脑缺血再灌注模型,缺血2h后再灌注l,3,7d。用免疫组化染色法分别检测缺血皮质Fas、FasL蛋白表达。结果:与模型组比较。益气活血方组Fas、FasL蛋白表达显降低。结论:益气活血方可能通过抑制Fas、FasL蛋白表达,减轻气虚血瘀证局灶性脑缺血再灌注损伤。 相似文献