Machine learning algorithm to construct cuproptosis- and immune-related prognosis prediction model for colon cancer

BACKGROUND Over the past few years, research into the pathogenesis of colon cancer has progressed rapidly, and cuproptosis is an emerging mode of cellular apoptosis. Exploring the relationship between colon cancer and cuproptosis benefits in identifying novel biomarkers and even improving the outcome of the disease.AIM To look at the prognostic relationship between colon cancer and the genes associated with cuproptosis and the immune system in patients. The main purpose was to assess whether rea...     

Cuproptosis-related gene SLC31A1 is a potential predictor for diagnosis,prognosis and therapeutic response of breast cancer

Cuproptosis is a recently reported novel way of cell death. A comprehensive study regarding expression, function and mechanism of cuproptosis-related genes in breast cancer is still absent. In this work, a series of in silico analyses were employed and SLC31A1 was selected as the most potential cuproptosis-related gene in breast cancer, which was statistically upregulated and possessed significant abilities to predict diagnosis, prognosis and drug response. Moreover, SLC31A1 was significantly positively correlated with different immune cell infiltration levels, immune cell biomarkers or immune checkpoints in breast cancer. Upstream G2E3-AS1/let-7a-5p and CDKN2B-AS1/let-7b-5p pathways were found to be responsible for SLC31A1 upregulation in breast cancer based on competing endogenous RNA mechanism. Furthermore, we found that SLC31A1 overexpression might be also induced by its high copy number level in breast cancer. Collectively, our current data elucidated that cuproptosis-related SLC31A1 might be a promising diagnostic/prognostic biomarker and drug responsive predictor in breast cancer.     

铜死亡在鼻咽癌治疗中的作用研究进展

鼻咽癌(NPC)是我国多发恶性肿瘤，约四分之三的患者诊断时已为局部晚期。放疗和全身化疗是目前NPC患者的重要治疗方法，患者预后情况不容乐观。因此，改善NPC患者的预后是目前临床上亟待解决的问题。最近，一项最新研究发现了一种新的调节性细胞死亡方式铜死亡，它在一定程度上降低了肿瘤治疗中的耐药性，对肿瘤的防治具有巨大的潜能。因此，本文将展开阐述铜死亡抗肿瘤的作用机制及在NPC治疗中的作用研究进展，为NPC患者的治疗提供新的依据。