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921.
Hur GY Park HJ Lee HY Koh DH Lee BJ Choi GS Kim SH Ye YM Park HS 《Yonsei medical journal》2011,52(3):488-494
Purpose
Our previous study indicated that the presence of wheat-specific IgG1 and IgG4 antibodies was associated with work-related symptoms in workers exposed to wheat flour. We performed this study to investigate the genetic polymorphisms of β2-adrenergic receptors and wheat-specific antibodies in association with the clinical parameters of baker''s asthma.Materials and Methods
In total, 379 subjects working in a single industrial bakery were enrolled in this study. The skin prick test was performed with common inhalant allergens and wheat flour extract. The presence of serum- specific IgE, IgG1, and IgG4 antibodies to wheat flour were determined by ELISA. Whole blood samples were obtained for genotype analysis. Subjects were genotyped with regard to five candidate single nucleotide polymorphisms (SNPs) of the β2-adrenergic receptor gene (ADRB2; -47 T>C, 46 A>G, 79 C>G, 252 G>A, and 523 C>A) using a single-base extension method.Results
No significant associations were observed between the genotype/allele frequencies of any of the SNPs tested and any clinical parameters. The haplotype of ADRB2 (GAA composed of 46 A>G, 252 G>A, and 523 C>A) was significantly associated with work-related symptoms (p<0.05). Moreover, in subjects with the AG or GG genotype at 46 A>G and haplotype [GAA] of ADRB2, the prevalence rates of wheat-specific IgG1 antibodies and lower respiratory symptoms increased significantly with exposure intensity (both p<0.05).Conclusion
The findings of the present study suggest that ADRB2 genetic polymorphism may contribute to the development of work-related symptoms in workers exposed to wheat flour, which can lead to baker''s asthma. 相似文献922.
目的探讨哮喘患儿血清中肺表面活性蛋白A、D(SP-A,SP-D)、白介素8(IL-8)、免疫球蛋白E(IgE)含量的变化及其分析研究。方法测定30例儿童哮喘急性发作期和缓解期的SP-A、SP-D、IL-8、IgE及同期健康儿童30例。结果急性发作期的SP-A、SP-D水平均显著低于对照组(P<0.01),IL-8、IgE水平均显著高于对照组(P<0.01);缓解期的SP-A、SP-D水平明显高于发作期(P<0.05),IL-8水平明显低于发作期(P<0.05),IgE水平与发作期相比差异无显著性(P>0.05)。结论儿童哮喘的发作虽然是多种病因引起,IL-8、IgE等在其中的病理生理、免疫病理改变有重要作用。证明SP-A、SP-D含量及功能改变与哮喘的发病、发展关系密切。 相似文献
923.
Involvement of small airways, those of <2 mm in internal diameter, is present in all stages of asthma and contributes substantially to its pathophysiologic expression. Therefore, small airways are a potential target to achieve optimal asthma control. Airway tone, which is increased in asthma, is mainly controlled by the vagus nerve that releases acetylcholine (ACh) and activates muscarinic ACh receptors (mAChRs) post-synaptically on airway smooth muscle (ASM). In small airways, M3 mAChRs are expressed, but there is no vagal innervation. Non-neuronal ACh released from the epithelial cells that may express choline acetyltransferase in response to inflammatory stimuli, as well as from other structural cells in the airways, including fibroblasts and mast cells, can activate mAChRs. By antagonizing M3 mAChR, the contraction of the ASM is prevented and, potentially, local inflammation can be reduced and the progression of remodeling may be averted. In fact, ACh also contributes to inflammation and remodeling of the airways and regulates the growth of ASM. Several experimental studies have demonstrated the potential benefit derived from the use of mAChR antagonists, mainly long-acting mAChR antagonists (LAMAs), on small airways in asthma. However, there are several confounding factors that may cause a wrong estimation of the relationship between LAMAs and small airways in asthma. Further studies are needed to differentiate broncholytic and anti-inflammatory effects of LAMAs and to better understand the interaction between LAMAs and corticosteroids, also in the context of a triple therapy that includes a β2-AR agonist, at different levels of the bronchial tree. 相似文献
924.
Wendy F. Davidson Donald Y.M. Leung Lisa A. Beck Cecilia M. Berin Mark Boguniewicz William W. Busse Talal A. Chatila Raif S. Geha James E. Gern Emma Guttman-Yassky Alan D. Irvine Brian S. Kim Heidi H. Kong Gideon Lack Kari C. Nadeau Julie Schwaninger Angela Simpson Eric L. Simpson Marshall Plaut 《The Journal of allergy and clinical immunology》2019,143(3):894-913
925.
Daniel P. Potaczek Sebastian D. Unger Nan Zhang Styliani Taka Sven Michel Nesibe Akdağ Feng Lan Markus Helfer Christoph Hudemann Markus Eickmann Chrysanthi Skevaki Spyridon Megremis Anne Sadewasser Bilal Alashkar Alhamwe Fahd Alhamdan Mübeccel Akdis Michael R. Edwards Sebastian L. Johnston Harald Renz 《The Journal of allergy and clinical immunology》2019,143(4):1403-1415
926.
Siroux V Boudier A Anto JM Cazzoletti L Accordini S Alonso J Cerveri I Corsico A Gulsvik A Jarvis D de Marco R Marcon A Marques EA Bugiani M Janson C Leynaert B Pin I 《Allergy》2008,63(5):547-554
Background: Health-related quality-of-life (HRQL) has been poorly studied in large samples of asthmatics from the general population. HRQL and its relationship to asthma-severity were assessed among 900 asthmatics enrolled in the European Community Respiratory Health Survey.
Methods: Among asthmatics, 864 completed the short form-36 (SF-36) questionnaire and 477 also completed the Asthma Quality-of-life Questionnaire (AQLQ). A 4-class asthma-severity scale, combining clinical items, forced expiratory volume in 1 s and the level of treatment and the different asthma-severity components (each of the clinical items and hospitalization) were studied in relation to HRQL.
Results: Mean SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores (45.5 and 48.8 respectively) were lower than expected in a general population. The mean total AQLQ score was 5.8. The AQLQ score and to a lesser extent the PCS score were significantly related to the 4-class asthma-severity scale, although the risk of having a lower HRQL score did not vary proportionally across the levels of severity. Asthma-severity had no impact on the MCS score. Asthma attack frequency and hospitalization were associated with both total AQLQ and PCS scores, whereas nocturnal symptoms and lung function were more strongly related to the AQLQ and PCS score respectively.
Conclusion: In population-based asthmatics, the specific AQLQ questionnaire, and also to a lesser extent the generic SF-36 questionnaire, were sensitive to asthma-severity. Frequencies of asthma attacks, of nocturnal symptoms and hospitalization for asthma have independent impact on HRQL. 相似文献
Methods: Among asthmatics, 864 completed the short form-36 (SF-36) questionnaire and 477 also completed the Asthma Quality-of-life Questionnaire (AQLQ). A 4-class asthma-severity scale, combining clinical items, forced expiratory volume in 1 s and the level of treatment and the different asthma-severity components (each of the clinical items and hospitalization) were studied in relation to HRQL.
Results: Mean SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores (45.5 and 48.8 respectively) were lower than expected in a general population. The mean total AQLQ score was 5.8. The AQLQ score and to a lesser extent the PCS score were significantly related to the 4-class asthma-severity scale, although the risk of having a lower HRQL score did not vary proportionally across the levels of severity. Asthma-severity had no impact on the MCS score. Asthma attack frequency and hospitalization were associated with both total AQLQ and PCS scores, whereas nocturnal symptoms and lung function were more strongly related to the AQLQ and PCS score respectively.
Conclusion: In population-based asthmatics, the specific AQLQ questionnaire, and also to a lesser extent the generic SF-36 questionnaire, were sensitive to asthma-severity. Frequencies of asthma attacks, of nocturnal symptoms and hospitalization for asthma have independent impact on HRQL. 相似文献
927.
928.
T. Yokoi Norio Hirabayashi Masafumi Ito Yutaka Uno Toyonori Tsuzuki Yasushi Yatabe Yoshihisa Kodera 《Virchows Archiv : an international journal of pathology》1997,431(4):275-282
We identified eight patients with bronchiolitis obliterans (BO) in the autopsies of 81 bone marrow transplant (BMT) recipients.
Rapidly progressive dyspnoea and cough were the main presenting symptoms in all eight patients, associated with overinflation
and/or infiltrative opacity seen on chest X-ray and obstructive disorder revealed by pulmonary function tests. Early lesions
were characterized by epithelial loss and an inflammatory infiltrate containing foamy histiocytes with mild luminal narrowing.
Partial or total occlusion of the bronchiolar lumina by fibrous connective tissue was the feature of late lesions. Both changes
were coexistent in all cases. In one case, small bronchi with cartilage were also affected by the obstructive process, showing
bronchitis obliterans. All eight patients showed non-obstructive broncho-bronchiolitis characterized by denuding of respiratory
epithelium, mural oedema and an inflammatory infiltrate in addition to BO, and these changes were also seen in 18 patients
without BO. The submucosal glands of large bronchi and the trachea showed mucous retention and a mild inflammatory infiltrate
in four of the eight patients. Coexistent infectious processes were seen in all cases, cytomegalovirus and Aspergillus being
the most frequent organisms. BO probably develops as an immunopathological event related to graft-versus-host disease (GVHD)
during the impaired immune status phase of the post-BMT period, possibly initiated by infection. Bronchial gland involvement
in chronic GVHD is one of the factors responsible for this abnormal immune status.
Received: 14 January 1997 / Accepted: 5 March 1997 相似文献
929.
支气管哮喘患儿红细胞免疫功能与脂质过氧化关系的探讨 总被引:6,自引:0,他引:6
目的 :探讨了支气管哮喘患儿红细胞免疫功能的变化及其与脂质过氧化的关系。方法 :应用红细胞酵母花环法测定了 32例支气管哮喘患儿红细胞免疫功能和化学比色法测定血浆丙二醛 (MDA) ,超氧化物歧化酶 (SOD) ,谷胱甘肽过氧化物酶 (GSH -PX)含量 ,并与 35名正常健康儿童作对照。结果 :支气管哮喘患儿RBC-IC花环率和MDA水平明显地升高 (P <0 .0 1 ) ,而RBC -C3bR、SOD、GSH -PX、SOD/MDA低于正常 (P <0 .0 1 ) ,相关分析显示 :RBC -C3b花环与MDA呈显著的负相关 (r=- 0 .4 30 7,P <0 .0 5 ) ,RBC -ICR与MDA呈正相关 (r=0 .6 384 ,P <0 .0 1 )。结论 :支气管哮喘患儿红细胞免疫粘附功能降低 ,与活性氧代谢紊乱密切相关 相似文献
930.
目的 观察过敏性哮喘患儿外周血嗜酸性粒细胞及淋巴细胞表面趋化因子受体CCR3与CCR5表达的改变。方法 以16例急性发作及25例缓解期过敏性哮喘患儿和20例健康儿童为主要观察对象,用流式细胞术测定外周血粒细胞群及淋巴细胞群中CCR3与CCR5的表达。结果 过敏性哮喘患儿缓解组CCR3~+淋巴细胞亚群百分率[(4.2±1.9)%],尤其是CCR3~+嗜酸性粒细胞百分率[(3.5±1.6)%]较正常组[(3.0±1.3)%,(1.2±0.5)%]明显增高;急性发作组CCR3~+淋巴细胞亚群与嗜酸性粒细胞百分率[(3.5±1.5)%,(2.2±1.0)%]虽也高于正常组,但较缓解组则出现下降。发作组CCR5~+淋巴细胞亚群仅见增高趋势。结论 CCR3~+嗜酸性粒细胞与淋巴细胞亚群异常升高可能为过敏性哮喘患儿免疫系统异常的一个特征性表现;与缓解组比较,发作组CCR3~+嗜酸性粒细胞及淋巴细胞亚群反而降低,可能和该类细胞向炎症部位趋化并参与了过敏性免疫炎症反应有关。 相似文献