Vitapex糊剂与根管糊剂治疗慢性根尖周炎的临床疗效比较

目的比较Vitapex与根管糊剂治疗慢性根尖周炎的临床疗效。方法选择我院2009年12月-2012年12月确诊的慢性根尖周炎患者80例（共120颗患牙）,根据人院顺序分为研究组（Vitapex糊剂）与对照组（传统根管糊剂）各40例,比较两组的疗效。结果研究组应用Vitapex糊剂充填无效4例,总有效率达90．0％,对照组采用传统根管糊剂充填后无效10例,总有效率达75．0％,两组总有效率比较,差异存在统计学意义（P〈0．05）。研究组共6例主诉无痛,14例出现轻度疼痛,重度疼痛8例;对照组轻度疼痛13例,重度疼痛15例。研究组重度疼痛例数明显少于对照组,差异存在统计学意义（P〈0．05）。结论Vitapex糊剂治疗慢性根尖周炎的临床疗效优于根管糊剂,患者疼痛反应轻。     

奇正消痛贴+青鹏膏剂治疗陈旧性腰肌损伤的临床研究

目的探讨奇正消痛贴+青鹏膏剂治疗陈旧性腰肌损伤患者的临床疗效。方法对2011年9月份—2012年6月份来该院就诊,并确诊为陈旧性腰肌损伤78例患者(病程均在1年以上),观察并比较使用奇正消痛贴膏+青鹏膏剂1个疗程前后疼痛、压痛及功能改善情况,并观察治疗后局部不良反应的发生情况。结果 78例患者全部完成观察内容,患者经奇正消痛贴膏+青鹏膏剂治疗后明显减轻疼痛,显著改善腰椎功能,总有效率96.15%。极少数患者贴药部位发生皮肤过敏反应。结论奇正消痛贴膏+青鹏膏剂治疗慢性陈旧性腰肌损伤效果满意。     

排龈膏排龈在前牙固定修复中的应用研究

目的：探讨排龈膏在前牙固定修复中的应用。方法选择前牙固定修复患者85例（前牙124颗）,随机分成2组,分别采用排龈线和排龈膏法比较基牙预备体和印模的临床效果。结果排龈线和排龈膏法取得的基牙预备体和印模边缘清晰,两者比较差别无统计学意义（P＞0．05）。结论使用排龈线和排龈膏都能达到较好的排龈效果;排龈膏操作便捷,不容易使患者产生疼痛,更适合在临床上广泛应用。     

不同基质制备复方南星止痛贴膏剂的过程中指标成分损失对比

目的: 建立不同基质制备复方南星止痛膏中丁香酚、欧前胡素的含量测定方法,比较制备过程中丁香酚、欧前胡素损失。 方法: C₁₈色谱柱(4.6 mm×250 mm,5 μm),以甲醇-1%乙酸水溶液进行梯度洗脱(0～30 min,46%A;30～32 min,46%～61%A;32～34 min,61%A;34～42 min,61%～47%A;42～60 min,47%A),检测波长280,300 nm,柱温30 ℃。以丁香酚、欧前胡素的损失率为指标,比较不同基质制备的3种贴膏剂的优劣。 结果: 丁香酚和欧前胡素进样量分别在0.018 31～3.662 7,0.013 22～0.528 6 μg与峰面积线性关系良好(r=0.999 9)。3种贴膏剂制备过程中欧前胡素损失均较小,丁香酚损失均较大,其中凝胶膏剂制备过程中丁香酚损失最少。 结论: 建立的含量测定方法准确、稳定、分离效果好,可用于测定3种复方南星止痛贴膏中丁香酚、欧前胡素的含量;复方南星止痛凝胶膏剂优于其他2种基质制备的复方南星止痛贴剂。     

三色膏治疗早中期原发性膝骨关节炎的临床研究

目的:观察三色膏外敷治疗早中期膝骨关节炎(KOA)的疗效,比较三色膏外敷与美洛昔康口服治疗早中期KOA的临床疗效差异。方法:纳入136例早中期KOA患者,随机分为治疗组和对照组,每组各68例。治疗组采用三色膏外敷治疗,对照组给予美洛昔康片口服,两组均治疗6周。分别于治疗前及治疗3周、6周、12周、24周时,评定患者的WOMAC(Western Ontario and Mc Master Universities Arthritis Index)量表评分、膝关节疼痛视觉模拟评分(visual analog score,VAS)、5次坐-立试验时间及健康调查简表(SF-36)评分;比较两组患者的临床疗效。结果:治疗后,两组患者的WOMAC各项评分、疼痛VAS评分均明显降低,SF-36量表评分明显升高,5次坐-立试验时间明显缩短,与治疗前比较差异均有统计学意义(P0.05,P0.01)。治疗3周、6周、12周、24周时,治疗组患者的WOMAC各项评分均低于对照组(P0.05,P0.01);治疗6周、12周、24周时,治疗组患者的VAS评分均低于对照组(P0.05),5次坐-立试验时间较对照组明显缩短(P0.05,P0.01),SF-36量表评分高于对照组(P0.05,P0.01)。治疗3周、6周、12周、24周时,治疗组的临床总有效率分别为71.21%、90.91%、80.30%、74.24%,对照组分别为61.76%、76.47%、72.06%、64.71%;各时间点的临床疗效比较,治疗组均优于对照组(P0.05)。结论:三色膏与美洛昔康治疗早中期KOA均有效,三色膏既可明显缓解患者的疼痛症状,又可改善其膝关节活动度,提高生活质量,在恢复膝关节的力学平衡方面疗效优于美洛昔康。     

Development of Tomato Sambar Paste Stabilized by Hurdle Technology and Evaluation of Storage Stability

The study was undertaken to develop ready-to-use sambar paste stabilized by various hurdles vis a vis water activity, pH, temperature, and preservative. Physico-chemical characteristics such as pH, titratable acidity (TA), color changes, and microbiological profiles were monitored during four months of storage at 28 ± 3°C and 37°C. A Hedonic test was used to evaluate consumer perception and acceptability of sambar paste during storage. Color analysis showed significant (p < 0.05) decrease in the lightness (L) and yellowness (b*), while redness (a*) of the paste increased during storage at both the storage temperatures. Sensory evaluation showed that there was no significant difference (p > 0.05) in most of the sensory attributes during storage except color. The sambar paste was found to be microbiologically safe for four months at 37°C.     

丁桂活络凝胶膏的质量标准研究

目的:建立丁桂活络凝胶膏的质量标准。方法:采用薄层色谱(TLC)法鉴别制剂中的木香、羌活、独活;采用高效液相色谱法测定制剂中延胡索乙素的含量:色谱柱为Waters Symmetry Shield C18(250 mm×4.6 mm,5μm),流动相为甲醇-0.1%磷酸溶液(p H6.0,50∶50,V/V),流速为1.0 ml/min,检测波长为280 nm,柱温为25℃,进样量为10μl。结果:木香、羌活、独活的TLC图斑点清晰、分离度好。延胡索乙素的质量浓度在10.58⁵2.90μg/ml范围内与峰面积积分值呈良好线性关系(r=0.999 9);精密度、稳定性、重复性试验的RSD均≤0.72%,平均加样回收率为100.07%,RSD=0.65%(n=9)。结论:所建质量标准可用于丁桂活络凝胶膏的质量控制。     

AH—plus糊剂在一次法根管治疗术中的疗效观察

目的观察AH—plus糊剂在一次法根管治疗术中的疗效。方法选择进行根管治疗的牙髓病及根尖周病患者172例,共186颗患牙,随机分成实验组（AH-plus糊剂组）93颗牙和对照组（碘仿氢氧化钙糊剂组）93颗牙,观察两组病例术后1周及1年的临床效果。结果实验组早期疼痛发生较少,疼痛发生率与对照组比较具差异有统计学意义,AH-plus充填后1年的有效率为96．70％,优于对照组的82．22％。结论AH-Plus糊剂充填根管可以有效减少一次法根管治疗术后急性疼痛的发生,其临床疗效优于碘仿氢氧化钙糊剂。     

三种根管糊剂用于一次性根管治疗术后的评价

目的：对AH Plus,Vitapex及Cortisomol糊剂在一次性根管治疗术后,对疼痛及远期疗效评价。方法：180颗患牙随机分为三组,分别以AH Plus,Vitapex和Cortisomol糊剂配合牙胶尖充填根管,对术后1周、3、6、12个月的疼痛及远期疗效进行评估。结果：术后1周随访,AH Plus、Cortisomol糊剂与Vitapex疼痛发生率有显著性差异,前两者之间无显著性差异;经3、6、12个月复查,在根尖周炎病例的治疗中,Vitapex与AH Plus和Cortisomol糊剂远期愈合率有显著性差异,后两者之间无显著性差异。结论：AH Plus和Cortisomol糊剂对一次性根管治疗术后疼痛的缓解有较好的效果,而Vitapex糊剂在促进根尖周组织的愈合方面,更具有优越性。     

Chemical Shrinkage of Low Water to Cement (w/c) Ratio CEM I and CEM III Cement Pastes Incorporating Silica Fume and Filler

Chemical shrinkage (CS) is the reason behind early age cracking, a common problem for concrete with low water to cement ratios (w/c < 0.35) known as Ultra-High- and High-Performance Concrete (U-HPC). However, to avoid the crack development initiated by autogenous shrinkage, a precise measurement of CS is required, as the values obtained can determine the correct amount of internal curing agent to be added in the mixture to avoid crack formation. ASTM C1608 is the standardized method for performing CS tests. In this study, recommendations are provided to improve the reliability of results obtained with this standard method, such as good compaction of samples and the use of superplasticizer (SP) for low w/c ratios (≤0.2). Cement pastes with CEM I and CEM III have been tested at different w/c ratios equal to 0.2, 0.3 and 0.4 with and without the addition of superplasticizer. CS results following ASTM-C1608 dilatometry showed that the presence of mineral additions such as silica fume and filler reduced the chemical shrinkage, while CS increased with increasing w/c. Low w/c ratio pastes of CEM III had slightly higher CS rates than CEM I, while the opposite was noticed at higher w/c. SEM images illustrated the importance of a careful compaction and SP use.