血脂康胶囊联合曲克芦丁治疗动脉粥样硬化血栓性脑梗死的临床研究

目的 探讨血脂康胶囊与曲克芦丁联合治疗动脉粥样硬化血栓性脑梗死的临床疗效。方法 选取2022年9月—2023年9月南阳市第二人民医院收治的100例动脉粥样硬化血栓性脑梗死患者,按随机数字表法将患者分对照组（50例）和治疗组（50例）。对照组患者静脉滴注曲克芦丁注射液,360 mg加入生理盐水150 mL,1次/d。在对照组的基础上,治疗组口服血脂康胶囊,2粒/次,2次/d。两组治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者症状改善时间、日常生活能力量表评分指数（Barthel）、脑神经功能损伤程度量表（NIHSS）评分、及血清因子脂蛋白相关磷脂酶A2(LP-PLA2)、高迁移率族蛋白B1(HMGB1)、氧化低密度脂蛋白（ox-LDL）和血管间黏附分子-1(VCAM-1)水平。结果 治疗后,治疗组总有效率为98.00%,明显高于对照组总有效率（80.00%,P<0.05）。治疗后,治疗组肢体无力、肢体麻木感、头痛、眩晕等症状改善时间均明显短于对照组（P<0.05）。治疗后,两组Barthel指数评分明显升高,而NIHSS评分明显降低（P<0.05）,且治疗组B...     

简体版改良Barthel指数在脑卒中恢复期中的信度与效度研究

目的:观察简体版改良Barthel指数量表(MBI)在评定脑卒中患者恢复期基础性日常生活活动(BADL)的信度和效度。方法:由2名研究员对100名符合入选标准的脑卒中恢复期患者进行BADL评定。在患者入院的次日,上午由评定员A、B使用MBI分别对每位患者的BADL进行评定,下午由评定员A使用MBI、评定员B使用BI分别对每位患者的BADL进行再次评定,收集整理数据并加以分析。采用相关系数(ICC)值描述评价者的重测信度、评价者间信度,采用Cronbach’sα系数进行计算量表的内部一致性;邀请6名高级职称康复专家对简体版MBI的内容效度(CVI)进行评估,采用Spearman相关性检验分析简体版MBI的校标效度(以BI为金标准),采用KMO检验、Bartlett球形检验和因子分析方法来分析构想效度。结果:6名专家对简体版MBI的条目水平CVI为0.83~1,量表水平CVI均值为0.95;简体版MBI各个条目、总分的重测信度为ICC=0.909~0.991;简体版MBI各个条目、总分的评定者间信度为ICC=0.880~0.992;简体版MBI内部一致性Cronbach’α系数为0.929;以BI为金标准,简体版MBI的校标效度(Spearman相关系数)依次为:进食(0.562)、个人卫生(0.701)、洗澡(0.715)、如厕(0.785)、穿衣(0.684)、大便控制(0.690)、小便控制(0.630)、床椅转移(0.925)、步行/轮椅(0.864)、上下楼梯(0.877)、总分(0.941),均P<0.001;简体版MBI构想效度结果显示,KMO统计量为0.877,Bartlett球形检验拒绝相关阵是单位阵(P<0.05),80.28%的总方差可由2个公因子解释,旋转后因子1有:洗澡、穿衣、如厕、床椅转移、步行/轮椅、上下楼;旋转后因子2有:进食、个人卫生、大便控制、小便控制。结论:简体版MBI量表不仅具有良好内容效度、重测信度、评定者间信度、内部一致性、校标效度和构想效度,而且易于掌握、使用方便。     

The Functional Independence of Patients With Stroke Sequelae: How Important Is the Speed,Oxygen Consumption,and Energy Cost of Walking?

ObjectiveTo evaluate the association between self-selected walking speed (S_free), oxygen consumption at S_free (Vo_2free), the oxygen cost of walking (Cw) at S_free, and mobility independence and independence for activities of daily living in individuals poststroke.DesignCross-sectional study.SettingHospital.ParticipantsIndividuals with stroke who were able to walk without human assistance were included. We included 90 individuals (N=90; mean age, 63.5±14.0y).InterventionsNot applicable.Main Outcome MeasuresCw was captured during walking from measurements of S_free and Vo_2free. We assessed mobility independence based on the modified Functional Ambulation Classification (mFAC) and independence in activities of daily living by the Barthel Index (BI). Multiple linear regression analyses were performed to evaluate the independence of Cw, Vo_2free, and S_free from the determination of BI and mFAC among the various characteristics of the population (age, stroke delay, body mass index, motor function, spasticity).ResultsWe reported Cw=0.36 mL/kg/m (interquartile range [IQR]=0.28 mL/kg/m), S_free=0.60±0.32 m/s, Vo_2free=11.2 mL/kg/min (IQR=1.8 mL/kg/min). The multiple linear regression analyses showed that Cw and S_free were independently associated with the BI (P<.01) and the mFAC (P<.01) scores. Vo_2free was not found to be an explanatory variable of functional independence (P>.05).ConclusionsCw was independently associated with functional independence. This association appears to be primarily determined by S_free and not Vo_2free, underscoring the importance of evaluating and acting on S_free to improve the functional independence of individuals with stroke.     

国内Barthel指数和改良Barthel指数应用的回顾性研究

目的: 系统回顾分析国内Barthel指数(BI)和改良Barthel指数（MBI）的发展及使用情况,以利于今后量表的规范化使用。方法: 通过系统回顾的方法对1979年以来有关BI与MBI的文献和书籍进行系统分析。结果：有关BI的文献723篇,其中,73.12%—84.39%作为判断康复疗效的指标,而针对其本身研究的文献仅发现1篇。在入选的29篇MBI文献中,66.67%—73.12%的文章显示MBI作为疗效的判断,但没有发现针对量表本身的研究。同时,涉及MBI的专业书籍中85%错误认为BI就是MBI。结论：BI和MBI是日常生活活动（ADL）评定及疗效判定的重要指标,但在国内使用中缺乏针对性的研究,使用混乱,甚至错误地将BI认为是MBI。因此,正确区分BI和MBI及规范化其使用方法是很有必要的。     

Efficiency of Neuromuscular Electrical Stimulation and Transcutaneous Nerve Stimulation on Hemiplegic Shoulder Pain: A Randomized Controlled Trial

Objective

To compare the efficacy of neuromuscular electrical stimulation (NMES) and transcutaneous nerve stimulation (TENS) on hemiplegic shoulder pain (HSP).

Frenchay活动量表对于我国脑卒中患者评定的效度研究

目的探讨Frenchay活动量表在我国脑卒中患者应用中的效度。方法选取脑卒中患者和正常人各39例。由同一评定者用Frenchay活动量表分别对两组受试者评定2次。首次评定患者时,评定Barthel指数1次。两个量表比较采用Spearman相关系数检验,两组Frenchay活动量表评分比较采用配对t检验。结果在脑卒中组中,Frenchay活动量表与Barthel指数的相关系数为0.727(P<0.001),各项得分和总分明显低于正常对照组(P<0.01)。结论Frenchay活动量表适用于我国脑卒中的评定。     

Electroacupuncture for Reflex Sympathetic Dystrophy after Stroke: A Meta-Analysis

Background: Reflex sympathetic dystrophy (RSD) is the common complication among stroke and cerebral injury patients, which is lack of safe and effective treatment. Electroacupuncture (EA) may potentially be a reliably therapy, but the evidence is insufficiency. Methods: Cochrane Library, MEDLINE, Embase, Chinese National Knowledge Infrastructure, Wan Fang Data, the Chinese Biology Medicine disc, etc., were searched, until July 20, 2018. We included random control trials that contrast EA with conventional rehabilitation therapy for the treatment of RSD. Main outcomes were visual analog scale score and Fugl-Meyer upper limb motor function scoring scale, other outcomes such as Barthel index, and hand swelling score were also collected. Data in included studies were extracted into an excel and pooled by Stata/MP 14.1. Results: We incorporated 13 studies involving 1040 RSD patients and outcomes were from 2 to 6 weeks' follow-up. The analgesic effect between 2 groups had statistically significant difference (weighted mean difference [WMD] = ?1.122, 95% confidence interval [CI] [?1.682 to ?.562], P?=?.000], a statistical difference existed in improving dysfunction between 2 groups: (WMD?=?6.039, 95% CI [2.231?.916], P?=?.000). EA groups had a better effect on improving activities of daily life abilities (WMD?=?12.170, 95% CI [6.657?17.682], P < .00011] and better detumescence effect (WMD = ?.800, 95% CI [?1.972 to ?.212], P = .000] contrast to conventional rehabilitation therapy. Conclusions: This meta-analysis supports that EA has a positive effect on alleviating pain, improving limb dysfunction, and promoting activities of daily living. On account of moderate-quality random control trials and high heterogeneity, further high-quality studies are imperative to optimize the EA treatment program.