复方消溃灵对消化性溃疡及萎缩性胃炎患者EGF与EGFR的影响

 目的探讨中药复方消溃灵对消化性溃疡及萎缩性胃炎患者血清、胃液EGF含量及胃粘膜EGFR表达的影响.方法采用放射免疫法及SABC免疫组化技术对24例消化性溃疡和27例萎缩性胃炎及12例"正常"胃粘膜者血清、胃液EGF含量及胃粘膜EGFR进行检测.结果治疗前,EGF含量,PU组明显低于对照组(P＜0.05),AG组显著高于对照组(P＜0.01),EGFR表达,PU组及AG组均较对照组增强(P＜0.05,p＜0.01);EGF含量及EGFR表达与治疗前比较,PU组变化显著(P＜0.01),AG组无明显差异(P＞0.05).结论消溃灵可显著提高消化性溃疡患者血清及胃液EGF含量并促进胃粘膜EGFR表达,对萎缩性胃炎患者无明显影响.     

高能量CO2点阵激光与点阵射频治疗萎缩性痤疮瘢痕的自身对照研究

目的 评价高能量CO₂点阵激光和点阵射频治疗萎缩性痤疮瘢痕的疗效及安全性。方法 随机分配半脸进行治疗,一侧使用DeepFx CO₂点阵激光,另一侧使用点阵射频。第一遍单点治疗凹陷痤疮瘢痕,第二遍全部痤疮瘢痕区域扫描。每次治疗间隔2个月,5次治疗结束后随访3个月,采用4分位数评分量表评价痤疮瘢痕改善情况,并观察并发症情况。结果本组共28例患者,治疗后两侧痤疮瘢痕改善无显著差异,CO₂点阵激光治疗侧色素沉着显著高于点阵射频治疗侧,CO₂点阵激光治疗时疼痛明显低于点阵射频治疗。两侧均未出现永久性色素改变和瘢痕。结论 高能量CO₂点阵激光和点阵射频均能有效改善萎缩性痤疮瘢痕,无永久性不良反应,均可作为痤疮瘢痕的治疗选择。     

Osteoperiosteal Decortication and Autogenous Cancellous Bone Graft Combined with Bridge Plating for Non-hypertrophic Diaphyseal Nonunion

BackgroudThe aim of this study was to evaluate results of osteoperiosteal decortication and autogenous cancellous bone graft combined with a bridge plating technique in atrophic and oligotrophic femoral and tibial diaphyseal nonunion.MethodsWe retrospectively reviewed 31 patients with atrophic or oligotrophic femoral and tibial diaphyseal nonunion treated with osteoperiosteal decortication and autogenous cancellous bone graft between January 2008 and December 2018. Patients with hypertrophic nonunion, infected nonunion, and nonunion treated with autogenous cancellous bone graft alone were excluded. The nonunion site was exposed by using the Judet technique of osteoperiosteal decortication. Nonunion with a lack of stability was stabilized with a new plate using a bridge plating technique or augmented by supplemental fixation with a plate. Nonunion with malalignment was stabilized with a new plate after deformity correction. Autogenous cancellous bone graft was harvested from the posterior iliac crest and placed within the area of decortication. A basic demographic survey was conducted, and the type of existing implants, mechanical stability of the implants, the type of implants used for stabilization, the operation time, the time to bone union, and postoperative complications were investigated.ResultsThe average follow-up period was 33.3 months (range, 8–108 months). The operation time was 207 minutes (range, 100–351 minutes). All but 1 nonunion (96.7%) were healed at an average of 4.2 months (range, 3–8 months). In 1 patient, bone union failed due to implant loosening with absorbed bone graft, and solid union was achieved by an additional surgery for stable fixation with a new plate, osteoperiosteal decortication, and autogenous cancellous bone graft. There were no other major complications such as neurovascular injuries, infection, loss of fixation, and malunion.ConclusionsOsteoperiosteal decortication and autogenous cancellous bone graft combined with stable fixation by bridge plating showed reliable outcomes in atrophic and oligotrophic diaphyseal nonunion. This treatment modality can be effective for treating atrophic and oligotrophic diaphyseal nonunion because it is very helpful stimulating bone union.     

Rhinoplasty and young’s operation in atrophic rhinitis

Rhinoplasty in atrophic rhinitis is a difficult surgery because the dorsal skin is adherent to the underlying structures. There is also more chance of postoperative injection. Our experience of various types of rhinoplasly in 25 atrophic rhinitis patients are presented here. The patients were from the age group 16 to 35 years. Most of the operations were done under local anaesthesia. Commonest graft used was conchal cartilage. Bone graft was avoided for augmentation because of its high rate of absorption in atrophic rhinitis. In 10 patients Young’s operation was done in one side along with rhinoplasty. Young’s operation was done only with skin layer.     

Novel treatment of atrophic rhinitis: early results

The aim of this randomized control trial, performed at a tertiary referral hospital, was to compare the therapeutic effectiveness of two novel treatment modalities, oral rifampicin and submucosal placentrex injection, in randomly selected patients of primary atrophic rhinitis regarding objective, subjective and histopathological improvement. Patients treated with oral rifampicin showed most promising results regarding objective, subjective and histopathological improvement with maximum disease-free interval on regular follow-up as compared to submucosal placentrex injections.     

保妇康栓联合硝呋太尔制霉菌素栓改善萎缩性阴道炎患者阴道镜检查效果的临床分析

目的探讨萎缩性阴道炎患者在阴道镜检查前应用保妇康栓联合硝呋太尔制霉菌素栓治疗对阴道镜检查效果的改善情况。方法将2015年1-12月来我院宫颈病变门诊的150例萎缩性阴道炎患者随机平均分为2组,观察组实行硝呋太尔制霉菌素栓与保妇康栓治疗,对照组实行保妇康栓治疗。比较两组的临床效果。结果治疗后,观察组的有效率高于对照组(94.7%vs.82.7%,P<0.05)。观察组和对照组的不良反应率分别为2.7%和9.3%,两组比较差异无统计学意义(P>0.05)。结论绝经期患者在阴道镜检查前使用保妇康栓联合硝呋太尔制霉菌素栓治疗萎缩性阴道炎安全有效,有助于提高阴道镜检查的满意度。     

上颌窦内提升术同期植入短种植体的临床应用

目的：通过临床观察和X 线测量评估上颌窦内提升术同期植入短种植体的临床观察。方法45例患者接受上颌窦内提升术,同期植入60枚Bicon短种植体（60枚种植体都小于或等于8mm）,术后3个月进行种植义齿修复,术后3个月到3年进行临床及X 线检查随访。结果种植体术后3年成功率为100%,种植体稳定且能负担固定修复体的咬合。 X 线片显示所有种植体底部及周围均有硬组织包绕,且牙槽嵴顶水平稳定,垂直骨吸收量<1 mm。结论上颌窦内提升术同期植入短种植体能减少术后反应,近期取得较好的临床效果,扩大了上颌后牙区骨量不足的种植适应证范围。     

Generation of an attenuated Salmonella-delivery strains expressing adhesin and toxin antigens for progressive atrophic rhinitis,and evaluation of its immune responses in a murine model

An expression/secretion plasmid containing genes encoding the FimA, CP39, PtfA, ToxA and F1P2 antigens associated with porcine pneumonic pasteurellosis and progressive atrophic rhinitis (PAR) was constructed and harbored in an attenuated Salmonella Typhimurium, which was used as the vaccine candidate. The immune responses induced by this delivery strain were investigated in a murine model. Each antigen secreted from the delivery strain was confirmed by Western blot analysis. Thirty BALB/c mice were divided equally into two groups; group A were intranasally inoculated with the mixture of the five delivery strains, and group B were inoculated with sterile PBS. In group A, all antigen-specific serum IgG were significantly increased compared to those of group B from the 2nd week post-inoculation (WPI) till the 8th WPI. All antigen-specific mucosal IgA in group A were also significantly greater than those of group B. In addition, the significant splenic lymphocyte proliferative responses, the elevations of CD3⁺CD4⁺, CD3⁺CD8⁺ and B-cell populations, and the induction of IFN-γ expression in group A were observed. In conclusion, the mixture of five delivery strains expressing specific antigen for these diseases was found to be capable of inducing significant humoral and cellular immune responses.     

Clinical observation on acupuncture treatment of 36 cases of chronic atrophic gastritis

目的:观察针灸结合治疗慢性萎缩性胃炎的临床疗效.方法:慢性萎缩性胃炎患者36例,按中医辩证,分型施以针灸治疗.治疗前及治疗后均进行胃镜、体表胃电图、胃酸和胃蛋白酶、血中胃泌素、血中前列腺素E及胃粘膜胃泌素细胞等理化指标检查.结果:针灸治疗本病有较好的效果,显效好转率达97.2%,临床症状消失率达97.0%.治疗后可使患者血中前列腺素E等防御性因子增强,使患者从胃内低酸转向正常状态,胃动力功能增强,胃电图幅值回升,并可促使胃泌素释放,有利于胃酸的分泌.结论:针灸治疗萎缩性胃炎简便经济,无副作用,见效快,疗效肯定,可重复性强,具有一定的临床意义.     

养胃舒胶囊治疗慢性萎缩性胃炎疗效观察

目的观察养胃舒胶囊治疗慢性萎缩性胃炎的临床疗效。方法 75例慢性萎缩性胃炎患者随机分为治疗组（40例）和对照组（35例）,分别给予养胃舒胶囊和叶酸片治疗,疗程5个月。结果治疗组的总有效率为87.50%,对照组为57.14%（P〈0.01）;两组各主要症状疗效无显著性差异（P〉0.05）;治疗组胃黏膜萎缩和肠化生的总有效率分别为77.78%和71.43%,对照组分别为52.17%和47.37%,治疗组胃黏膜萎缩及肠化生的总有效率均高于对照组（P〈0.05）。结论养胃舒胶囊治疗慢性萎缩性胃炎疗效确切。