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101.
Enrica Martinotti Vincenzo Calderone Maria Cristina Breschi Paola Bandini Pier Luigi Cioni 《Phytotherapy research : PTR》1997,11(8):612-614
The pharmacological study of the responses evoked by a dried aqueous extract of Artemisia verlotorum on different guinea-pig and rat isolated organs in vitro, suggests a possible muscarinic activity as a cause of the antihypertensive activity. The ability of atropine, in ileum preparations, and of Nω-nitro L -arginine methyl ester, in aortic preparations, to inhibit the plant effects seems to confirm the muscarinic nature of the responses © 1997 John Wiley & Sons, Ltd. 相似文献
102.
艾叶是生活和临床中最为常见的中药之一,具有适应性广、治疗效果优等特点。古代医籍文献中将艾叶功效归纳为散寒止痛、温经止血2大类,临床常治疗下焦虚寒及妇人血证等疾病。近年来,研究发现艾叶具有抗菌抗病毒、凝血止血、抗肿瘤、止咳平喘、镇痛抗炎、保肝利胆、调节血糖血脂等作用,可用于治疗妊娠呕吐、高脂血症、糖尿病、肿瘤等多种疾病。运用VOSviewer可视化软件构建知识图谱,并从艾叶的性味功效、组方配伍规律、临床应用和现代药理作用5个方面分析,展示艾叶在药用、食疗、外用、药理作用等方面的古今演变,将艾叶的古代传统功效与现代药理研究结合起来,为艾叶的现代研究和创新转化提供思路。 相似文献
103.
F. Macchioni S. Perrucci G. Flamini P. L. Cioni I. Morelli 《Phytotherapy research : PTR》1999,13(3):242-244
Methanol and aqueous extracts of Artemisia verlotorum and Santolina etrusca were screened in vitro against Saprolegnia ferax and for all extracts the MIC were determined. Screening was performed also on two fractions of the aqueous extracts. Copyright © 1999 John Wiley & Sons, Ltd. 相似文献
104.
105.
目的:测定青蒿中樟脑、龙脑、异龙脑含量.方法:采用毛细管气相色谱法,HP-5石英毛细管柱(30 m×0.25 mm×0.25 m);FID检测器;程序升温.结果:樟脑、龙脑、异龙脑进样量分别在0.196~9.82 ng、0.139~6.94 ng、0.0596~2.98 ng范围内有良好线性关系.平均回收率分别为99.0%、99.0%和98.7%.结论:本方法简单、准确,重复性好,可用于青蒿药材樟脑、龙脑、异龙脑的含量测定. 相似文献
106.
Artemisia annua L. contains artemisinin, an endoperoxide sesquiterpene lactone, mainly in its leaves and inflorescences. This compound and a series of derivatives have attracted attention because of their potential value as antimalarial drugs. In this review a survey of the currently available literature data is given. It includes phytochemical aspects, such as constituents ofA. annua, the artemisinin content during the development of the plant and its biosynthesis, isolation, analysis and stability. Total chemical synthesis of artemisinin is referred to, as well as structure—activity relationships of derivatives and simplified analogues. Pharmacological studies are summarized, including the mechanism of action, interaction of the antimalarial activity with other drugs, possible occurrence of resistance to artemisinin, clinical results, toxicological aspects, metabolism and pharmacokinetics. Finally, plant cell biotechnologyy is mentioned as a possible means to obtain plants and cell cultures with higher artemisinin contents, allowing an industrial production of pharmaceuticals containing this novel drug. 相似文献
107.
沈行良 Mogens NIELSEN Michael Robin WITT Olov STERNER Ola BERGENDORFF Mohammed KHAYYAL 《Acta pharmacologica Sinica》1994,(5)
从阿拉伯艾蒿提取到两种苯并二氮杂受体的配基,毛地黄黄酮和玄参黄酮。两种化合物在体外可抑制[~3H]地西泮和大鼠皮层细胞膜的结合,IC_(50)值分别为1.3μmol·L~(-1)和23μmol·L~(-1)。两种化合物GABA比分别为1.1和1.2,都可少量增加[~(35)S]TBPS的结合,提示这种化合物是苯并二氮杂受体的拮抗剂或部分激动剂。 相似文献
108.
109.
目的 研究青蒿油多相脂质体对不同肿瘤细胞株的生长抑制作用.方法 采用四甲基偶氮唑盐(MTT)法检测青蒿油多相脂质体对4种不同肿瘤细胞株的生长抑制作用.结果 青蒿油多相脂质体对人白血病HL-60及人红白血病K562、小鼠黑色素瘤B-16、人肝癌BEL-7402细胞的半抑制浓度(IC50)分别为124.00、390.14、391.94、854.01μg/mL,在浓度为520μg/mL时,对四种细胞株的抑制率分别为93.09%、70.56%、77.55%、40.00%.结论 青蒿油多相脂质体在体外对4种肿瘤细胞株均具有明显的抑制作用,具有开发成抗癌新药的潜力. 相似文献
110.
Recent concerns about the potential carcinogenicity of estragole and methyleugenol led a number of regulatory bodies to call for restrictions on the use of herbs that contain these constituents. A number of medicinal plants produce essential oils that contain estragole and methyleugenol, including Artemisia dracunculus L. (tarragon). Previous studies have proven the antidiabetic properties of tarragon. In order to address the safety concerns of estragole containing tarragon extracts, an extraction procedure was developed to minimize the estragole and methyleugenol content in tarragon extracts and the ethanol versus aqueous extracts from two Artemisia dracunculus cultivars (French and Russian tarragon) were tested for blood glucose lowering effects in rats. It could be demonstrated that aqueous extracts of both Artemisia cultivars did not contain detectable amounts of estragole and methyleugenol, whereas ethanol extracts (60% v/v) of the French cultivar contained higher levels of the aforementioned compounds than those of the Russian cultivar. Further testing revealed that Russian tarragon lowered blood glucose levels in rats after glucose challenge, with the ethanol extract being as active as the aqueous extract. The results suggest that by using adequate production procedures the amount of potentially harmful compounds in extracts can be limited without affecting the overall pharmacological activities of these preparations. 相似文献