应用层次分析法建立卫生技术综合评价指标体系

该研究利用专家研讨会、专家评分与层次分析法建立了卫生技术综合评价的指标体系及其权重系数，为农村卫生适宜技术推广项目评价、筛选适宜技术提供了方法学基础。     

国境口岸梅毒血清学检测程序标准化探讨

[目的]通过对不同梅毒血清学检测程序对梅毒抗体阳性检出率影响的比较,探讨国境口岸梅毒血清学检测标准化程序。[方法]比较检测程序Ⅰ(先做甲苯胺红不加热血清试验(TRUST)。阳性血清再做梅毒螺旋体抗体明胶颗粒试验(TPPA)确认)和检测程序Ⅱ(国家质检总局推荐程序,先做TPPA检测,再做TRUST和双抗原夹心法酶联免疫吸附试验TP．ELISA检测)对出入境人员梅毒抗体阳性检出率的差异性。[结果]从2002年7月～2004年3月采用检测程序Ⅰ,共检测出入境人员10509人,检出梅毒抗体阳性63例,检出率是5．99‰。从2004年4月～2006年3月采用检测程序Ⅱ,2年共检测出入境人员10076人,TPPA阳性141人,检出率是13．99‰。经卡方检验,2种检测程序间梅毒抗体阳性检出率存在显著性差异。[结论]检测程序Ⅱ可以大大提高梅毒抗体阳性检出率,值得重视。     

苍术炮制品及其辅料麦麸的薄层鉴别研究

目的建立苍术炮制品及其辅料麦麸的薄层鉴别方法。方法采用薄层鉴别方法,以硅胶G为吸附剂,石油醚(60-90℃)-乙酸乙酯(10∶1)为展开剂,展开并观察。结果苍术样品在与对照药材相同的位置上,显相同颜色的斑点;在与β-桉叶醇对照品色谱相应位置上,显一相同的紫红色斑点;炒后麦麸比炒前麦麸多一斑点;苍术炮制后的薄层色谱中大部分斑点的颜色比炮制前淡。结论本法操作简便,斑点明显,分离度和重现性好,可用于苍术药材的定性鉴别和辅料的研究。     

艾拉莫德(T-614)的合成工艺研究

目的对新药艾拉莫德（1）的合成工艺进行研究。方法以4-氯-3-硝基苯甲醚为起始原料，与苯酚反应生成4-苯氧基-3-硝基苯甲醚，再经还原、甲磺酰化、付-克酰基化、甲酰化、水解、环合，共7步反应制备得到（1）。结果（1）的化学结构经核磁共振谱、质谱确证，纯度（HPLC法）〉99％。结论该合成路线较短，反应条件温和，操作简便，收率较高（38％），易于工业化生产。     

腰麻-硬膜外联合麻醉的不良反应与处理

腰麻-硬膜外联合麻醉(CS-EA)吸取了腰麻和硬膜外麻醉共同特点。随着临床应用的增多,CS-EA也暴露出一些问题和缺点。临床应用时既要发现其优点,更要密切观察其不良反应,及时处理,保证患者安全。     

Chemiluminescence detection of opium poppy (Papaver somniferum) alkaloids

A review with 98 references. The determination of the opium poppy (Papaver somniferum) alkaloids and their semi-synthetic derivatives has important applications in industrial process monitoring, clinical analysis and forensic science. Liquid-phase chemiluminescence reagents such as tris(2,2'-bipyridyl)ruthenium(II) and acidic potassium permanganate exhibit remarkable sensitivity and complementary selectivity for many P. somniferum alkaloids, which has been exploited in the development of a range of analytical procedures using flow analysis, high-performance liquid chromatography, capillary electrophoresis and microfluidic instrumentation.     

Job Satisfaction and the Work Situation of Physicians: a survey at a German University hospital

Summary. Objective: Job demands and workload of hospital physicians are increasing. The object of this survey was to examine the factors that constitute job satisfaction and to analyse physicians’ work situation in the area of in-patient care. Methodology: 447 physicians at a German University Hospital received questionnaires with regard to work situation, job satisfaction and personal health. Data were analysed by MANOVA and multiple regression models. Results: A first regression model explained 53% of the variance in satisfaction with ‘work and profession’. Among the explanatory variables ‘superiors and hierarchy’ showed the highest beta-weight (β = −0.49). ‘Personal health’ also determined job satisfaction, for female physicians stronger (β = −0.31) than for male physicians (β = −0.11). In a second regression model on satisfaction with ‘Financial situation’ only 18% of the variance was explained, whereby ‘work condition on the ward’, ‘personal health’ and ‘collaboration between occupational groups’ showed the highest beta-weights. Discussion: Among resident physicians, work conditions, superiors, hierarchy, transparency and participation in decisions are very important variables for job satisfaction. Improvements in these aspects may improve job satisfaction and help to reduce physician shortage in hospitals. Submitted: 2 March 2005; Revised: 31 May, 29 August 2005, 15 November 2005; Accepted: 9 June 2006     

床旁结算模式在患者就诊流程中的优化应用:基于业财融合的视角

目的:从描述公立医院患者的就诊业务流程入手,分析我国公立医院患者出入院原有财务结算流程的主要弊端。在此基础上提出通过业务与财务融合,运用床旁结算模式对原有的住院结算方式进行改造的对策。方法:将床旁结算模式与传统结算模式的结算时长以及患者的评价满意度进行比较分析。结果:采用床旁结算模式与传统的结算模式相比具有很大的优势,得出了床旁结算实施过程中的五大成效。结论:床旁边结算模式是通过业财融合、流程再造,进一步改善医疗服务的典型方式,能够让广大民众对公立医院综合改革有真正的获得感。     

废弃烤烟叶绿原酸提取的动力学分析

目的 通过仿真模型复现烟叶绿原酸提取过程的含量变化规律。方法 基于天然药物提取过程中的动力学数学模型;建立低次烟叶绿原酸提取动力学方程在matlab平台的simulink仿真框图模型,并通过实验的方法确定模型参数。结果 运行仿真框图模型获得预测提取数据的曲线。通过在50℃、60℃、70℃三个温度梯度下,测定对应时间下的提取浓度,验证了仿真模型的准确性。结论 仿真模型可以在不同温度及不同时刻下,给出提取过程中绿原酸含量的大致变化规律,为绿原酸的提取工艺研究提供参考依据。