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91.
兔肢体火器伤海水浸泡后伤道周围骨骼肌组织能量代谢变化特点 总被引:1,自引:0,他引:1
目的 观察兔肢体火器伤合并海水浸泡时伤道周围骨骼肌组织能量代谢变化特点,为其治疗提供确实可靠 的理论依据。方法 以高速钢珠射击兔后肢,速度为600~800m s,伤后将实验兔随机分为海水浸泡组和单致伤组。将浸 泡组兔浸泡于人工配制的海水中30min,于伤前及伤后3、6、12、24h分别切取距伤道壁0.5cm(挫伤区,A区)、1.5cm(振荡 区,B区)处组织,测定Na - K -ATP酶活性和ATP含量,以及观察超微结构。结果 海水浸泡组各区骨骼肌组织Na - K - ATP酶活性、ATP含量均呈伤后3h较伤前明显下降的趋势(P<0.01),6~12h回升,24h再次呈下降的趋势,这与病理观 察发现的挫伤区和振荡区肌组织的线粒体形态结构的动态变化时相是一致的。结论 肢体火器伤合并海水浸泡,伤后6 ~12h骨骼肌组织能量代谢有一代偿过程,为外科清创的最佳时机。 相似文献
92.
This study independently examined the effects of three hydrotherapy interventions on the physiological and functional symptoms
of delayed onset muscle soreness (DOMS). Strength trained males (n = 38) completed two experimental trials separated by 8 months in a randomised crossover design; one trial involved passive
recovery (PAS, control), the other a specific hydrotherapy protocol for 72 h post-exercise; either: (1) cold water immersion
(CWI: n = 12), (2) hot water immersion (HWI: n = 11) or (3) contrast water therapy (CWT: n = 15). For each trial, subjects performed a DOMS-inducing leg press protocol followed by PAS or one of the hydrotherapy interventions
for 14 min. Weighted squat jump, isometric squat, perceived pain, thigh girths and blood variables were measured prior to,
immediately after, and at 24, 48 and 72 h post-exercise. Squat jump performance and isometric force recovery were significantly
enhanced (P < 0.05) at 24, 48 and 72 h post-exercise following CWT and at 48 and 72 h post-exercise following CWI when compared to PAS.
Isometric force recovery was also greater (P < 0.05) at 24, 48, and 72 h post-exercise following HWI when compared to PAS. Perceived pain improved (P < 0.01) following CWT at 24, 48 and 72 h post-exercise. Overall, CWI and CWT were found to be effective in reducing the physiological
and functional deficits associated with DOMS, including improved recovery of isometric force and dynamic power and a reduction
in localised oedema. While HWI was effective in the recovery of isometric force, it was ineffective for recovery of all other
markers compared to PAS.
An erratum to this article can be found at 相似文献
93.
Srámek P Simecková M Janský L Savlíková J Vybíral S 《European journal of applied physiology》2000,81(5):436-442
To differentiate between the effect of cold and hydrostatic pressure on hormone and cardiovascular functions of man, a group
of young men was examined during 1-h head-out immersions in water of different temperatures (32°C, 20°C and 14°C). Immersion
in water at 32°C did not change rectal temperature and metabolic rate, but lowered heart rate (by 15%) and systolic and diastolic
blood pressures (by 11%, or 12%, respectively), compared to controls at ambient air temperature. Plasma renin activity, plasma
cortisol and aldosterone concentrations were also lowered (by 46%, 34%, and 17%, respectively), while diuresis was increased
by 107%. Immersion at 20°C induced a similar decrease in plasma renin activity, heart rate and systolic and diastolic blood
pressures as immersion at thermoneutrality, in spite of lowered rectal temperature and an increased metabolic rate by 93%.
Plasma cortisol concentrations tended to decrease, while plasma aldosterone concentration was unchanged. Diuresis was increased
by 89%. No significant differences in changes in diuresis, plasma renin activity and aldosterone concentration compared to
subjects immersed to 32°C were observed. Cold water immersion (14°C) lowered rectal temperature and increased metabolic rate
(by 350%), heart rate and systolic and diastolic blood pressure (by 5%, 7%, and 8%, respectively). Plasma noradrenaline and
dopamine concentrations were increased by 530% and by 250% respectively, while diuresis increased by 163% (more than at 32°C).
Plasma aldosterone concentrations increased by 23%. Plasma renin activity was reduced as during immersion in water at the
highest temperature. Cortisol concentrations tended to decrease. Plasma adrenaline concentrations remained unchanged. Changes
in plasma renin activity were not related to changes in aldosterone concentrations. Immersion in water of different temperatures
did not increase blood concentrations of cortisol. There was no correlation between changes in rectal temperature and changes
in hormone production. Our data supported the hypothesis that physiological changes induced by water immersion are mediated
by humoral control mechanisms, while responses induced by cold are mainly due to increased activity of the sympathetic nervous
system.
Accepted: 4 February 1999 相似文献
94.
Aim: To elucidate the role of core and skin thermoreceptors in the release of growth hormone (GH) and prolactin (PRL), a sequence of two experiments using whole‐body (head‐out) and partial (one forearm) hot water immersions was performed. Methods: Experiment 1: Nine healthy men were exposed to head‐out and partial water immersions (25 min, 38–39 °C). Results: Head‐out immersion increased the core temperature (38.0 ± 0.1 vs. 36.7 ± 0.1 °C, P < 0.001) and plasma concentration of the hormones (GH, 16.1 ± 4.5 vs. 1.2 ± 0.4 ng mL?1, P < 0.01; PRL, 9.1 ± 1.0 vs. 6.4 ± 0.4 ng mL?1, P < 0.05). During the partial immersion the core temperature was slightly elevated (36.8 ± 0.1 vs. 36.6 ± 0.1, P < 0.001), the concentration of GH increased (4.8 ± 1.7 vs. 0.6 ± 0.3, P < 0.05), while plasma PRL decreased (7.6 ± 0.8, 6.0 ± 0.6, 5.2 ± 0.6, P < 0.01). Experiment 2: Seven volunteers immersed one forearm once in 39 °C and once in 38 °C water. The measurements were performed in 5‐min intervals. The GH concentration increased gradually from the beginning of the immersions (min 10; 39 °C: 1.9 ± 1.0 vs. 0.6 ± 0.3 ng mL?1, P < 0.01; 38 °C: 0.19 ± 0.03 vs. 0.14 ± 0.03, P < 0.05) and peaked after their completion (39 °C: +10 min, 3.7 ± 2.0, P < 0.001; 38 °C: +15 min, 0.86 ± 0.61, P < 0.01). The core temperature was unchanged until min 15 of the 39 °C bath. Thereafter, it increased about 0.15 °C above the baseline (P < 0.01). Immersion in 38 °C water did not induce core temperature changes. Conclusions: Peripheral thermoreceptors are involved in GH release when the body is exposed to elevated environmental temperature while a substantial elevation of core temperature is a precondition of PRL release. 相似文献
95.
Peter Tikuisis 《European journal of applied physiology》1989,59(5):334-341
Summary A multi-compartmental thermoregulatory model was applied to data of ten resting clothed males immersed for 3 h in water at
10 and 15°C. Clothing consisted of a dry suit and either a light or heavy undergarment, representing a total insulation of
0.15 (0.95) or 0.20 m2°CW−1 (1.28 clo), respectively. Data were grouped according to low (<14%) and high (14 to 24%) body fat individuals. Mean decreases
in rectal temperature ranged from 0.79 to 1.38°C, mean decreases in the mean weighted skin temperature ranged from 6.3 to
10.2°C, and mean increases in the metabolic rate ranged from 33.9 to 80.8 W. The model consists of eight segments, each representing
a specific region of the body. Each segment is comprised of compartments representing the core, muscle, fat, skin, and clothing.
Each compartment is assigned thermophysical values of heat conduction and heat capacitance, and with the exception of clothing,
physiological values of blood flow and metabolic heat production. During cold exposure, responses are directed towards increased
heat production in the form of shivering and heat conservation in the form of vasoconstriction and convective heat exchange
at the vascular level. Agreement between the model predictions and the experimental observations was obtained by adjusting
the parameters governing these responses. These adjusted parameters were 1) the onset of limb shivering with an exponential
half-time of 30 min, 2) the fractional value of 0.5 for the convective heat exchange between the core compartments of the
limbs and the blood flowing through these compartments, 3) the fractional contribution of trunk shivering to overall shivering,
which ranged from 0.77 to 0.95, and 4) the onset of vasoconstriction with exponential half-times that ranged from 3 to 25
min. Steady state was predicted to occur within 4 h and a heat balance analysis indicated that the limbs were responsible
for most of the body's heat loss while acquiring most of their own heat from the trunk through convective heat exchange with
the central blood. 相似文献
96.
目的:探索并构建理想的兔膝关节开放性海水浸泡损伤的动物模型。方法取新西兰白兔60只,建立兔膝关节开放性损伤模型,按照不同的海水浸泡时间分为对照组、0.5 h组、1 h组、3 h组和6 h组,每组各12只。对照组不予处理,各实验组制备膝关节开放性伤口,分别给予相应的海水浸泡时间。术后观察实验动物伤口及存活情况,于术后7 d抽取各组白兔膝关节液,采用酶联免疫吸附法检测关节液中炎性因子白细胞介素1-β(IL-1β)和肿瘤坏死因子-α(TNF-α)的含量。结果3 h组和6 h组的7 d存活率分别为91.7%、75.0%,其余各组均为100.0%;1 h组、3 h组和6 h组的14 d存活率分别为91.7%、83.3%和58.3%,其余各组均为100.0%。术后7 d,3 h组和6 h组中关节液IL-1β水平分别为(37.50±6.1) pg/mL和(38.40±5.1) pg/mL,明显高于其他各组,差异均有统计学意义(P>0.05),而3 h组和6 h组中关节液IL-1β水平比较差异无统计学意义(P>0.05);术后7 d,1 h组和3 h组关节液中的TNF-α水平分别为(297.48±35.7) pg/mL和(312.84±34.0) pg/mL,高于0.5 h组和对照组,低于6 h组,差异均有统计学意义(P<0.05),而1 h组和3 h组关节液中的TNF-α水平比较差异无统计学意义(P>0.05)。结论海水浸泡3 h构建兔膝关节海水浸泡损伤的动物模型具有动物存活率高、炎性反应活跃等特点,是一种理想的关节开放性海水浸泡损伤的动物模型。 相似文献
97.
考察了两种非调和型,两种调和型正畸粘接剂在不同浸水时间,放置时间,酸蚀时间条件下的粘接抗张强度,结果表明:(1)4种粘接剂在37℃100%rh环境中5min后的粘接强度均大于2.5MPa,在37℃水中浸泡1d后的粘接强度均大于6MPa,两种非调和型粘接的粘接强度在1d内随时间延长而增加;(2)在37℃,100%rh环境中,4种粘妆剂的液剂先涂于牙面1~10min后再粘接,所得粘接强度无明显变化;( 相似文献
98.
Objective:
Stress can lead to various changes in the gastrointestinal tract of rats. The present study was designed to compare the effect of palm vitamin E (PVE) and α-tocopherol (α-TF) supplementations on the gastric parameters important in maintaining gastric mucosal integrity in rats exposed to water immersion restraint stress (WRS). These parameters include gastric acidity, plasma gastrin level, gastric prostaglandin E2 (PGE2), and gastric lesions.Materials and Methods:
Sixty male Sprague-Dawley rats (200-250 g) were divided into three equal groups: a control group, which received a normal rat diet (RC), and two treatment groups, receiving oral supplementation of either PVE or α-TF at 60 mg/kg body weight for 28 days. Each group was further divided into two groups: the nonstress and stress groups. The stress groups were subjected to 3.5 h of WRS once at the end of the treatment period. Blood samples were then taken to measure the gastrin level, after which the rats were killed. Gastric juice was collected for measurement of gastric acidity and gastric tissue was taken for measurement of gastric mucosal lesions and PGE2.Results:
Exposure to stress resulted in the production of gastric lesions. PVE and α-TF lowered the lesion indices as compared to the stress control group. Stress reduced gastric acidity but pretreatment with PVE and α-TF prevented this reduction. The gastrin levels in the stress group were lower as compared to that in the nonstress control. However, following treatment with PVE and α-TF, gastrin levels increased and approached the normal level. There was also a significant reduction in the gastric PGE2 content with stress exposure, but this reduction was blocked with treatment with both PVE and α-TF.Conclusion:
In conclusion, WRS leads to a reduction in the gastric acidity, gastrin level, and gastric PGE2 level and there is increased formation of gastric lesions. Supplementation with either PVE or α-TF reduces the formation of gastric lesions, possibly by blocking the changes in the gastric acidity, gastrin, and gastric PGE2 induced by stress. No significant difference between PVE and α-TF was observed. 相似文献99.
微重力条件下人体体液调节模型的分析与改进思考 总被引:1,自引:0,他引:1
航天和模拟微重力时研究表明:微重力与现有模拟微重力模型时人体生理学变化的主要差异表现在低压区循环和体液、电解质代谢。微重力生理研究的人体模型在进一步了解微重力对人体的生理影响和机理中不可缺少,有必要将现有人体模拟微重力模型加以改进。利用人体不同角度和不同压力制度的立位倾斜(HUT)加下体正压、头低位卧床(HDT)加上体负压,测量心血管参数、体液调节因子、肾排泄的有关指标,与航天中的相应指标对照,筛 相似文献
100.
目的 探讨外科标准“4C”(颜色、致密度、收缩性、出血 )在判定海水浸泡肢体火器伤失活肌组织的可靠性。方法 以滑膛枪发射质量为 0 .2 5 g、速度为 6 0 0~ 80 0 m/ s钢球击中兔后肢 ,将致伤兔浸泡于人工海水中 30~ 6 0 min后出水。伤后 6~ 8h以“4C”标准分级判定肌组织活力 ,并运用图象分析技术 ,观察损伤组织显微病理改变与“4C”标准之间的关系。结果 χ2 检验显示“4C”标准中与失活组织的密切程度依次为 :收缩性、出血、致密度 ,而颜色与肌组织活力无关。病理观察显示肌组织变性、坏死 ,尤以肌间隙肿胀明显。结论 判定海水浸泡火器伤失活组织主要依据肌组织的收缩性、出血与致密度的变化。 相似文献