三妙丸薄层扫描鉴定

成药三妙丸及各单味药材采用阴性、阳性双对照,用λ_s 270nm,λR 370nm 薄层扫描得色谱图,1号峰鉴别黄柏,2号峰鉴别牛膝,3、4、5、6号峰鉴别苍术。用λ_s 340nm,λ_R 520nm测定三妙丸中黄柏的含量,均得到较为满意的结果。     

浅析我国《药品管理法》对假劣药的界定

修订后的《药品管理法》的一个重要特点就是扩大了假劣药定义的外延并加大了对制售假劣药品的处罚力度，而要如实恰当地对违法行为量刑处罚，就必须对假劣药品赋以明确概念。因此，界定假劣药品的意义十分重要和必要。以美国对不合格药品的划分为对照，探究我国对假劣药的界定及存在问题，并提出一些建议。     

高校图书馆藏书霉菌孳生情况初步调查

目的调查安徽省高校图书馆藏书霉菌孳生情况。方法用定点抽查法对馆内古籍典藏书库、过期书刊库和流通书刊库藏书中霉菌种类、分布及危害情况进行调查。结果共分类鉴定霉菌34种,隶属于5科12属。抽查藏书2682册,藏书霉损率20.4%(547/2682),其中过期书刊霉损率为36.0%(371/1030),与古籍善本和流通书刊相比差异有统计学意义(p<0.01)。在霉损藏书中,霉变、生霉和霉烂的藏书分别占66.0%(361/547)、22.5%(123/547)和11.5%(63/547)。结论安徽省高校图书馆藏书霉菌孳生较为普遍,在馆藏图书中,过期书刊遭霉损较严重。     

顺德港客运口岸禁止人境携带物截获情况分析

[目的)掌握顺德港客运口岸禁止入境携带物截获的种类、季节变化规律,为制定科学的监管措施提供科学依据.[方法]对顺德港客运口岸2006年1月一2007年9月截获的禁止入境携带物,利用统计学方法进行分类、统计,找出其中的规律.[结果]顺德客运口岸截获的禁止入境携带物以水果类为主,占截获总数的74.2%.截获携带物数量的消长具有一定的季节性,与国人特有出游习惯和传统习俗有着密不可分的联系,8月、lO月较高,l一3月较低.[结论]应根据顺德港客运口岸禁止入境携带物的种类以及季节变化情况,制定与之相对应的监督管理措施.     

多种药材与制剂中大黄酚与大黄素含量测定改进方法

目的:改进大黄酚与大黄素的测定方法。方法:通过甲醇提取与酸水解同步进行,用高效液相色谱法简便、快捷、准确地测定了多种药材与制剂中大黄酚与大黄素含量。色谱条件为:Shimadzu VP—ODS C_(18)(150 mm×4.6 mm,5μm)为色谱柱,甲醇-0.1%磷酸(85:15)为流动相,流速:1.0 mL·min~(-1),检测波长为254 nm。结果:通过方法学考察,大黄酚的进样量在0.022～0.32μg(r=0.9999),大黄素的进样量在0.015～0.22μg(r=0.9999)范围内,呈良好的线性关系。大黄酚与大黄素的平均回收率(n=3)分别为96.10%～101.7%和96.75%～100.9%。结论:改进方法检测效率高,检测成本低,环境污染轻。     

龙口口岸蚊类及蜚蠊的初步调查

目的了解龙口口岸蚊、蜚蠊的种类及季节消长情况,分析其传播疾病的潜在危险性,为制定口岸传染病防控措施提供科学依据。方法蚊类采用人工小时法、诱蚊灯诱捕法和勺取法;蜚蠊采用瓶诱法。结果捕获蚊类3属6种;以淡色库蚊为优势蚊种;全年蚊类活动呈单峰型,8-9月份密度高峰。蜚蠊2科2属3种,5、8月份为密度高峰。结论初步摸清了龙口口岸蚊、蜚蠊种群构成、密度和季节消长等情况。     

蒙药配合超短波、中频电治疗膝关节骨性关节炎84例观察

目的探讨蒙药配合超短波、中频电疗治疗膝关节骨性关节炎的疗效。方法84例膝关节骨性关节炎患者,随机分为联合治疗组46例,对照组38例。联合治疗组即珍宝丸联合超短波、中频电疗治疗;对照组采用蒙药珍宝丸治疗．结果联合治疗组,显效29例（占63．04％）,有效14例占（30．43％）,无效3例（占6．52％）,总有效率93．48％,明显高于对照组（氏0．05）。结论蒙药口服配合膝关节超短波、中频电疗治疗膝关节骨性关节炎能起到标本兼治的作用,疗效显著。     

Breeder and batch-dependent variability in the acquisition and performance of a motor skill in adult Long-Evans rats

Reaching tasks are popular tools for investigating the neural mechanisms of motor skill learning and recovery from brain damage in rodents, but there is considerable unexplained variability across studies using these tasks. We investigated whether breeder, batch effects, experimenter, time of year, weight and other factors contribute to differences in the acquisition and performance of a skilled reaching task, the single pellet retrieval task, in adult male Long-Evans hooded rats. First, we retrospectively analyzed task acquisition and performance in rats from different breeding colonies that were used in several studies spanning a 3 year period in our laboratory. Second, we compared reaching variables in age-matched rats from different breeders that were trained together as a batch by the same experimenters. All rats had received daily training on the reaching task until they reached a criterion of successful reaches per attempt. We found significant breeder-dependent differences in learning rate and final performance level. This was found even when age-matched rats from different breeders were trained together by the same experimenters. There was also significant batch-to-batch variability within rats from the same breeder trained by the same experimenter. Other factors, including weight, paw preference and the experimenter, were not as strong or consistent in their contributions to differences across studies. The breeder and batch effects found within the same rat strain may reflect genetic and environmental influences on the neural substrates of motor skill learning. This is an important consideration when comparing baseline performance across studies and for controlling variability within studies.     

Clinical effects of STW 5 (Iberogast®) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis

Abstract  STW 5, a herbal extract, is effective for the treatment of symptoms in patients with functional dyspepsia (FD). However, its mode of action is still unclear and a modulation of gastric motility is hypothesized. This multicentre, placebo-controlled double-blind study addressed the question of whether STW 5 accelerates gastric emptying in patients with FD and gastroparesis. One-hundred and three patients diagnosed with FD were randomly assigned to a treatment with either STW 5 or a liquid placebo for 28 days. The primary end point of the study was a change of a validated gastrointestinal symptom (GIS) score under treatment. Additionally, patients underwent a ¹³C octanoic acid breath test for the assessment of the gastric half-emptying time ( t _1/2). Patients with prolonged t _1/2 were diagnosed with gastroparesis and requested to repeat the test at the end of treatment. A change of t _1/2 was defined a secondary study end point. t _1/2 was prolonged in 48.6% of patients in the STW 5 group and in 43.8% of the placebo group. During treatment, t _1/2 increased non-significantly in patients treated with STW 5 (+23 ± 109 min; P  = 0.51) and slightly accelerated among patients in the placebo arm (−26 ± 51 min; P  = 0.77) ( P  = 0.49). The improvement of the GIS ( P  = 0.08) and the proportion of patients with a treatment response ( P  = 0.03) were more pronounced in the STW 5 group. Our findings suggest that the clinical effects of STW 5 in patients with FD and gastroparesis are not directly mediated by an acceleration of gastric emptying. A clear-cut correlation with symptom improvement is still lacking.     

巴音布鲁克羊选育方向探讨

巴音布鲁克羊是经过若干世纪的培育而形成的地方肉羊品种，产区在海拔2500m以上的高寒山区盆地。该品种毛色为黑头、黄白身，成年公着体重69.5kg，母羊43.2kg。具有抗严寒、耐放牧、合群性强等特点。曾经用多个品种进行杂交改良，目前主要以本品种选育为主。