中西医结合治疗口腔扁平苔藓的临床疗效观察

目的观察盐酸米诺环素和维A酸乳膏联合用药在治疗寻常痤疮中的疗效,探讨其应用价值。方法将60例寻常痤疮患者随机分为实验组和对照组,观察治疗前后皮损改善情况,按4级评分法进行评估。结果实验组有效率为71．4％,对照组有效率为38．9％。结论盐酸米诺环素联合维A酸乳膏治疗寻常痤疮疗效显著,安全可靠,值得临床推广应用。     

治疗痤疮新药sarecycline概述

摘 要Sarecycline是过去40年来首个专门针对皮肤病设计的口服抗菌药,这种首创、窄谱四环素类药在临床研究中已被证明用药后3周可使皮肤炎性皮损显著改善,且有良好的安全性和耐受性,适用于治疗罹患中度至重度痤疮的患者。     

桐油联合阿维A酸对银屑病的疗效及其对IL-23/Th17信号通路的影响

目的 观察桐油联合阿维A酸对轻、中度寻常型银屑病的疗效及其对IL-23/Th17信号通路的影响。方法 将196例寻常型银屑病患者随机分为桐油组及对照组,每组98例,对照组患者均给予阿维A酸联合窄谱中波紫外线（NB-UVB）治疗,桐油组患者在对照组治疗基础上给予桐油外敷。以银屑病皮损面积和严重程度指数（psoriasis area and severity index,PASI）评价桐油组及对照组疗效。酶联免疫吸附试验法（ELISA）检测治疗前后2组皮损组织中IL-17、IL-22、TNF-α和IL-23水平变化。免疫组织化学法分析治疗前后2组皮损组织中Th17细胞含量变化。结果 桐油组的总有效率（94.90%）显著高于对照组（76.53%）（P<0.05）。与治疗前相比,治疗后2组PASI评分均显著降低（P<0.01）,且治疗后桐油组显著低于对照组（P<0.05）。与治疗前相比,治疗后2组皮损中IL-23、IL-17、IL-22和TNF-α水平均显著降低（P<0.05）,且治疗后桐油组显著低于对照组（P<0.05）。治疗后2组患者皮损组织中Th17细胞百分比显著低于治疗前,且桐油组显著低于对照组（P<0.05）。桐油组不良反应发生率（14.29%）略高低于对照组（10.20%）,但差异不具有统计学意义。结论 桐油外敷联合阿维A酸治疗轻、中度寻常型银屑病有较好的疗效,其机制可能与抑制患者皮损组织中IL-23/Th17信号通路的活性有关。     

Changes due to cooking and sterilization in low molecular weight carbohydrates in immature seeds of five cultivars of common bean

Immature seeds of five bean cultivars (flageolet-type and those intended for dry-seed production) were assessed for changes in water-soluble carbohydrates including raffinose family oligosaccharides (RFOs) due to boiling, sterilization, and storage of the sterilized product. About 100?g fresh weight of edible portion of fresh bean seeds contained 2449.3–3182.6?mg total soluble sugars, of which RFOs comprised 44–49%. The highest amounts of these compounds were found in the seeds of the cultivars Laponia and Mona. The dominant oligosaccharide was stachyose. Boiling fresh seeds to consumption consistency reduced total soluble sugars and RFOs: average values were 57% and 55%, respectively. Sterilization in cans resulted in 65% reductions of both total soluble sugars and RFOs. In general, there were no changes in the content of soluble sugars in canned and sterilized products stored for 12?months.     

A single nucleotide polymorphism −35 kb T > C (rs9264942) is strongly associated with psoriasis vulgaris depending on HLA-Cw06

HLA class I molecules play a role both in viral infection control and in autoimmune diseases development. rs9264942T > C polymorphism in HLA-C gene was found to impact on HLA-C surface expression level and to be associated with HIV-1 control. It was found that these HLA alleles which protect against AIDS are associated with autoimmune disease e.g. psoriasis vulgaris (PsV). Whether rs9264942 SNP is associated with PsV was investigated here. rs9264942T > C was genotyped in 292 PsV patients, and 254 controls using TaqMan Genotyping Assay.     

果酸换肤治疗轻中度痤疮的护理干预

目的观察果酸换肤治疗轻中度痤疮患者的临床疗效,并探讨治疗过程中的护理干预措施.方法将2018年10月~2019年9月期间本科治疗的76例寻常痤疮患者,随机分为对照组(36)和观察组(40).对照组接受0.025%维A酸乳膏外涂,每晚一次,于临睡前点涂患处.观察组接受果酸换肤治疗配合粉刺挤压术,两周一次,两个月后比较两组患者皮损改善情况.结果观察组的总有效率为87.50%,显著高于对照组(77.78%),差异具有统计学意义(P<0.05).不良反应主要为白霜、烧灼感、刺痛,红斑以及色素沉着.结论果酸换肤可以有效治疗轻中度寻常痤疮,明显减少痤疮皮损面积,减轻炎症,配合多种护理措施干预,可提高患者依从性配合治疗,提高疗效,减少不良反应的发生率.     

CO2点阵激光联合异维A酸胶丸治疗寻常性痤疮的有效性和安全性

目的探讨CO2点阵激光联合异维A酸胶丸治疗寻常性痤疮的有效性与安全性。方法将本院收治的94例寻常性痤疮患者随机分为对照组和观察组,各47例。对照组给予CO2点阵激光治疗,观察组联合异维A酸胶丸治疗。比较两组治疗效果。结果观察组色素沉着消退总有效率高于对照组(P<0.05)。治疗后,观察组AA、IL-8、SHBG水平及皮损、HAMA和HAMD评分均低于对照组(P<0.05)。两组不良反应总发生率无显著差异(P>0.05)。结论 CO2点阵激光联合异维A酸胶丸可有效减少痤疮患者的皮损情况,改善炎症及心理压力,且安全性高。     

Clinical and usability study to determine the safety and efficacy of the Silk'n Blue Device for the treatment of mild to moderate inflammatory acne vulgaris

Abstract

Introduction: Home devices for acne vulgaris have emerged as a way to utilize our current light based technology for the care of our patients suffering from acne vulgaris. Materials and methods: Patient received eight treatments with the Silk'n Blue device over a 4-week period. Follow-up visits were at 1 month and 3 months. Results: Seventeen subjects were entered into this institutional review board (IRB) approved clinical research project. There was a statistically significant decrease in mean acne counts from baseline through the follow-up visits, p = 0.002. Percent reduction was also statistically significant, p = 0.041. The study also showed that 36.4% of the patients had complete clearance with the study device. 100% of the patients showed full comprehension with the label for the device. There were no adverse events. Photos were captured. Discussion: The Silk'n Blue device has an array of 24 LEDs emitting a spectrum of light in the blue-violet range of light (405–460 nm). Subjects enrolled in this clinical trial clearly were able to understand the labeling for the device. Conclusions: The Silk'n Blue device is a safe efficacious at home device for the treatment of mild to moderate inflammatory acne vulgaris.