Does supplementation with green tea extract improve acne in post-adolescent women? A randomized,double-blind,and placebo-controlled clinical trial

BackgroundGreen tea is believed to have beneficial effects in the prevention and treatment of acne.ObjectiveTo examine the effects of a decaffeinated green tea extract (GTE), providing a daily dose of 856 mg of epigallocatechin gallate (EGCG) upon women with post-adolescent acne.MethodsA randomized, double-blind, placebo-controlled clinical trial was conducted from May 2012 through October 2013. A final group of 80 subjects were randomly assigned to receive either 1500 mg of decaffeinated GTE or placebo (cellulose) daily for 4 weeks. Inflammatory lesion counts were used as the major outcome measurement. At baseline and after 4 weeks of treatment, anthropometric measurements, fasting glucose levels and a lipid profile were measured from both groups.ResultsSixty-four of 80 women, from 25 to 45 years of age with moderate-to-severe acne completed the study. Statistically significant differences were noted in inflammatory lesion counts distributed on the nose, periorally and on the chin between the two groups. However, there were no significant differences between groups for total lesion counts. Within-group comparison revealed that the GTE group had significant reductions in inflammatory lesions distributed on the forehead and cheek, and significant reductions in total lesion counts. GTE resulted in significant reductions in total cholesterol levels within the GTE group.ConclusionsGTE resulted in significant reductions in lesions located on the nose, perioral area and chin. More research is required to determine whether a decaffeinated GTE standardized for EGCG content will provide clinical benefits in women with post-adolescent acne.     

枇杷清肺饮加减治疗寻常型痤疮135例疗效观察

目的:观察枇杷清肺饮加减内服治疗寻常型痤疮的疗效.方法:将135例寻常型痤疮患者随机分为2组,治疗组85例,采用枇杷清肺饮加减内服,对照组50例,采用口服维安脂胶囊.观察两组治疗后疗效并进行比较,对临床痊愈患者进行3个月随访.结果:治疗组总有效率94.4%,对照组82.0%,两组比较差异有显著性(P＜0.05).结论:枇杷清肺饮加减是治疗寻常型痤疮的有效方法,值得临床推广.     

中空纤维分离-高效液相色谱法测定复方痤疮凝胶中主药的含量

目的 建立中空纤维分离-高效液相色谱(HPLC)法测定复方痤疮凝胶剂中主药含量的方法. 方法 采用中空纤维处理凝胶样品,含量测定以Venusil XBP-C₁₈色谱柱(4.6 mm×150 mm,5 μm)为固定相,以磷酸盐缓冲液(取0.015 mol.L^-1磷酸二氢钾溶液,磷酸溶液调节pH至3.0)-乙腈为流动相进行梯度洗脱;进样量:20 μL;柱温:30 ℃;流速:1.0 mL.min^-1;紫外检测波长:克林霉素磷酸酯:210 nm,维A酸:350 nm. 结果 主成分峰与相邻杂质峰分离度＞1.5. 克林霉素磷酸酯在48.00～480.00 μg.mL^-1范围内线性关系良好,r＝0.999 8,平均回收率为99.96%,RSD为0.69%(n＝6),维A酸在1.00～20.00 μg.mL^-1范围内线性关系良好,r＝0.999 7,平均回收率为99.99%,RSD为1.24%(n＝6). 结论 该方法简单、可靠,可用于复方痤疮凝胶剂中的样品处理和含量测定.     

口服米诺环素联合过氧化苯甲酰治疗痤疮疗效观察

目的 探讨米诺环素联合外用过氧化苯甲酰治疗痤疮的疗效性,分析两者联合用药与单独口服米诺环素在治疗痤疮疗效方面的差异性,从而为痤疮临床治疗提供较好的方案.方法 将45名患者随机分为治疗组和对照组,治疗组接受米诺环素联合过氧化苯甲酰治疗,对照组接受米诺环素治疗,对治疗组和对照组不同疗程(用药后2、4、6、8周及1个月)治愈...     

强脉冲光治疗寻常性痤疮疗效评价

目的:评价强脉冲光治疗寻常性痤疮的疗效及安全性。方法:120例寻常性痤疮患者随机分为两组:治疗组60例,采用YK-IPL560光子治疗仪治疗,每2周1次,5次为1个疗程;对照组60例,外用他扎罗汀乳膏,每晚用药1次,8周为1个疗程。分别记录两组患者治疗前、后粉刺、丘疹、脓疮、结节的皮损数量,观察皮损消退的情况及不良反应。结果:治疗组痊愈11例,显效27例,有效18例,无效4例,总有效率为93.3%。对照组痊愈9例,显效18例,有效16例,无效17例,总有效率为71.7%。治疗组疗效优于对照组(P<0.01)。结论:YK-IPL560光子治疗仪治疗轻中度炎性痤疮对痤疮疤痕、色素沉着、毛孔粗大等皮肤改善的效果较好,舒适安全,易于操作,患者耐受性好。     

重用金银花治疗中重度痤疮的疗效观察

目的探讨重用金银花治疗中重度痤疮疗效观察。方法患者分成五组,第一组服用异维甲酸和外用氯柳酊;第二组服用强力霉素和外用氯柳酊;第三组服用附方一和外用氯柳酊;第四组服用异维甲酸和附方一并外用氯柳酊;第五组服用强力霉素和附方一并外用氯柳酊。疗程共6周,每两周随访一次,分别计录患者的愈显率和自觉满意率。结果组A、B、C患者的愈显率分别为65.00%、58.33%和83.33%。与组A、B相比,组C患者的愈显率显著增大(P<0.05);组A、B、C患者的满意率分别为78.33%、71.67%和96.67%。与组A、B相比,组C患者的满意率明显增大(P<0.05)。结论重用金银花等中草药单用或和西药联用,均能取得比单用西药较好疗效,从而提高医疗服务质量,促进医患沟通,为医院创造更大的经济价值。     

雄激素对痤疮影响及治疗的研究进展

痤疮是临床常见病、多发病。所以导致发生痤疮的主要因素——雄激素成为众多医家关注的热点。就雄激素对痤疮的发病机制和治疗方面的研究进展作一综述。     

雄激素受体基因CAG多态性与痤疮中医分型的相关性研究

目的探讨雄激素受体基因CAG多态性与痤疮中医分型的相关性。方法应用PCR方法扩增,对肝郁气滞型和痰瘀热结型痤疮患者的阳性PCR产物进行测序,测序结果使用澳大利亚生物数据库W eb Angis分析。结果肝郁气滞型痤疮患者的雄激素受体基因CAG微卫星片段长度的平均值是23.87±2.97;痰瘀热结型痤疮患者的雄激素受体基因CAG微卫星片段长度的平均值是20.43±2.98,两型间进行比较雄激素受体基因CAG微卫星片段的长度的平均值有显著性差异(P<0.05)。结论雄激素受体基因CAG多态性与痤疮中医分型有关。