全文获取类型
收费全文 | 14449篇 |
免费 | 598篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 106篇 |
儿科学 | 561篇 |
妇产科学 | 112篇 |
基础医学 | 2535篇 |
口腔科学 | 225篇 |
临床医学 | 501篇 |
内科学 | 2389篇 |
皮肤病学 | 165篇 |
神经病学 | 917篇 |
特种医学 | 503篇 |
外国民族医学 | 2篇 |
外科学 | 2347篇 |
综合类 | 822篇 |
现状与发展 | 1篇 |
预防医学 | 453篇 |
眼科学 | 99篇 |
药学 | 2488篇 |
中国医学 | 106篇 |
肿瘤学 | 782篇 |
出版年
2023年 | 429篇 |
2022年 | 1354篇 |
2021年 | 901篇 |
2020年 | 374篇 |
2019年 | 494篇 |
2018年 | 475篇 |
2017年 | 379篇 |
2016年 | 124篇 |
2015年 | 142篇 |
2014年 | 282篇 |
2013年 | 285篇 |
2012年 | 291篇 |
2011年 | 284篇 |
2010年 | 196篇 |
2009年 | 188篇 |
2008年 | 177篇 |
2007年 | 190篇 |
2006年 | 284篇 |
2005年 | 726篇 |
2004年 | 858篇 |
2003年 | 522篇 |
2002年 | 221篇 |
2001年 | 232篇 |
2000年 | 250篇 |
1999年 | 232篇 |
1998年 | 252篇 |
1997年 | 199篇 |
1996年 | 266篇 |
1995年 | 382篇 |
1994年 | 337篇 |
1993年 | 343篇 |
1992年 | 288篇 |
1991年 | 283篇 |
1990年 | 210篇 |
1989年 | 223篇 |
1988年 | 205篇 |
1987年 | 198篇 |
1986年 | 184篇 |
1985年 | 204篇 |
1984年 | 204篇 |
1982年 | 177篇 |
1981年 | 155篇 |
1980年 | 143篇 |
1979年 | 134篇 |
1978年 | 130篇 |
1977年 | 107篇 |
1976年 | 123篇 |
1974年 | 76篇 |
1973年 | 83篇 |
1972年 | 73篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
992.
《Renal failure》2013,35(7):1044-1053
AbstractObjective: The objective of this review is to explore the concept of phase 0, its contribution and also its practical guidance in drug development process. The process of drug development is protracted, complicated and requires lot of money. Phase 0 focuses on the aspect of microdosing, which determines the relation between PK & PD profile of drug; also selection of lead compound. Concept of phase 0 balances the planning of study scale between animal and human being, and creates a new way of defining phase I. Time is not too far when advance techniques and methods will be developed for the phase 0 studies to make it convenient and widely applicable in the design and development of majority of drugs. Conclusion: Although studies are yet to be done for phase 0 trial, it can be recognized that phase 0 trials would provide an opportunity to generate essential human PK and PD data much earlier in a drug development process, which could be a major advantage in design and decision making for further clinical development of an agent. 相似文献
993.
Vladan Stevanović Zoran Blagojević Agnica Petković Miodrag Glišić Jelena Sopta Valentina Nikolić Milan Milisavljević 《International orthopaedics》2013,37(12):2475-2481
Purpose
It has been demonstrated that the semitendinosus tendon can regenerate after being harvested in its whole length and thickness for anterior cruciate ligament (ACL) reconstruction. Ultrasound studies and guided biopsies of the regenerated tendon have shown compatibility and resembling features of the normal tendon. The question is if this neo-tendon is biologically and functionally adequate for re-use?Methods
Two randomised groups of 150 volunteers were followed up for two years after harvesting the semitendinosus only (25) or the semitendinosus and gracilis tendons (25) in ACL reconstruction. The patients were followed up with clinical and ultrasound examinations, biopsies and histological tests. Surgical exploration was done in three patients for macroscopic verification. The injected arteries of four lower limbs were dissected and the tendon’s arterial supplies were examined.Results
Seventy-two percent of the cases showed regeneration of the semitendinosus tendons. The neotendons were inserted mostly below the knee joint (83.3 %) where they had fused with the gracilis tendon, and above the joint (60 %) when the gracilis was harvested as well. The isokinetic strength of the hamstrings and quadriceps was not significantly diminished on the operated side. A macroscopic and histological analysis of the regenerated tendons demonstrates close resemblance to normal anatomy, with focal areas of fibrosis. In one patient the regenerated tendon was used for medial patellofemoral ligament reconstruction.Conclusion
The semitendinosus muscle can recover and the tendon has great potential to regenerate after harvesting for ACL reconstruction. Our data suggest that the regenerated tendons could be used for iterative ligament reconstruction. 相似文献994.
995.
996.
997.
998.
应用目前较广泛的Microsoft出品的Excel5.0对实验室室内质量控制数据进行处理,克服手工计算,绘图繁琐精确性差的缺点,与专用软件包相比,也具有更强的扩充性和更大的灵活性,对实验数据的计算机管理进行了初步的尝试。 相似文献
999.
This article examines the metabolic performance of an elite cyclist, Lance Armstrong, before and after his diagnosis with testicular cancer. Although a champion cyclist in 1-day events prior to his diagnosis of testicular cancer at age 25, he was not a contender in multi-day endurance cycle races such as the 3-week Tour de France. His genetic makeup and physiology (high VO2max, long femur, strong heavy build) coupled with his ambition and motivation enabled him at an early age to become one of the best 1-day cyclists in the world. Following his cancer diagnosis, he underwent a unilateral orchiectomy, brain surgery and four cycles of chemotherapy. After recovering, he returned to cycling and surprisingly excelled in the Tour de France, winning this hardest of endurance events 7 years running. This dramatic transformation from a 1-day to a 3-week endurance champion has led many to query how this is possible, and under the current climate, has led to suggestions of doping as to the answer to this metamorphosis. Physiological tests following his recovery indicated that physiological parameters such as VO2max were not affected by the unilateral orchiectomy and chemotherapy. We propose that his dramatic improvement in recovery between stages, the most important factor in winning multi-day stage races, is due to his unilateral orchiectomy, a procedure that results in permanent changes in serum hormones. These hormonal changes, specifically an increase in gonadotropins (and prolactin) required to maintain serum testosterone levels, alter fuel metabolism; increasing hormone sensitive lipase expression and activity, promoting increased free fatty acid (FFA) mobilization to, and utilization by, muscles, thereby decreasing the requirement to expend limiting glycogen stores before, during and after exercise. Such hormonal changes also have been associated with ketone body production, improvements in muscle repair and haematocrit levels and may facilitate the loss of body weight, thereby increasing power to weight ratio. Taken together, these hormonal changes act to limit glycogen utilization, delay fatigue and enhance recovery thereby allowing for optimal performances on a day-to-day basis. These insights provide the foundation for future studies on the endocrinology of exercise metabolism, and suggest that Lance Armstrong's athletic advantage was not due to drug use. 相似文献
1000.
Hoei-Hansen CE Carlsen E Jorgensen N Leffers H Skakkebaek NE Rajpert-De Meyts E 《Human reproduction (Oxford, England)》2007,22(1):167-173
BACKGROUND: Testicular germ cell tumours (TGCTs) originate from a common precursor, carcinoma in situ (CIS). Diagnosis at the CIS stage is desirable as it minimizes the necessary treatment. A detailed clinical evaluation of an approach to detect CIS cells in the ejaculate using primordial germ cell/gonocyte markers is presented. METHODS: Immunocytological staining for AP-2gamma [and in some cases, OCT-3/4, NANOG or placental alkaline phosphatase (PLAP)] was performed in semen samples from 294 infertile patients and 209 patients with TGCTs or other diseases. RESULTS: Presence of AP-2gamma-stained cells was detected in 50% of participants with CIS and in 33.9% of TGCT patients before treatment (non-seminomas: 56.6%, seminomas: 17.4%). OCT-3/4 results were similar to those of AP-2gamma, whereas NANOG and PLAP stainings were unsuitable. Sensitivity was 54.5% for participants harbouring pre-invasive CIS but reduced in participants with overt TGCTs, perhaps because of obstruction. Assay specificity was 93.6%, positive predictive value (PPV) 83.3% and negative predictive value (NPV) 60.3%. CONCLUSIONS: Immunocytological semen analysis based on expression of fetal germ cell markers in exfoliated cells has auxiliary diagnostic value, as it detects some patients with CIS/incipient tumour, but a negative result does not exclude TGCT. Further effort is needed to improve this assay, for example, by employing a more sensitive biochemical method of detection. 相似文献