羧甲基茯苓多糖对小鼠子宫颈癌U_(14)肺转移的影响

本文观察了羧甲基茯苓多糖对近交系615小鼠子宫颈癌肺转移的抑制作用。结果表明肺转移率为64％(9/16),转移灶指数为1.43个;肿瘤对照组分别为94％(15/16)及5.88个;转移灶抑制率为75.68％。对照组瘤重明显大于实验组,分别为2.46g和1.88g,抑瘤率为23.58％。上述结果提示:羧甲基茯苓多糖确有一定的抗癌活性。     

异维A酸联合白花蛇舌草注射液治疗重度痤疮36例

痤疮是青年人群中最常见的一种皮肤病，重度痤疮常因面部出现较多炎性皮疹、囊肿、结节而使容貌受损，极大地影响患者身心健康。本病治疗方法较多，但疗效不满意。2000年以来，笔者应用口服异维A酸联合白花蛇舌草针肌肉注射治疗本病，取得较好效果，现报道如下。     

托尼萘酸治疗老年戊型肝炎

目的：观察托尼萘酸治疗老年戊型肝炎的安全性及临床疗效。方法：56例老年戊型肝炎病人分为治疗组和对照组，2组病人均给予常规护肝、支持、对症治疗。治疗组36例，男性28例，女性8例：年龄（67&;#177;s11）a。加用托尼萘酸，2片，po，tid。对照组20例，男性16例，女性4例：年龄（66＋12）a，仅给予基础治疗。治疗后4，8wk时比较2组病人的临床指标改变。     

患有了宫肌瘤，能否服用活血化淤药

我今年26岁，已婚未育，近2个月每次月经干净后3天左右子宫又会出血6～7天，去医院做B超检查子宫有2个肌瘤，分别为1.8厘米×1.6厘米和2.5厘米×1.9厘米；左侧附件有1个囊肿，3.8厘米×1.9厘米，考虑是生理性囊肿。医生给我开了消炎止血的药和茯苓桂枝丸。请问：（1）市面上有2种茯苓桂枝丸，一种浓缩丸，一种是大蜜丸，这2种桂枝茯苓丸对子宫肌瘤的治疗效果是否一样，听医生说这种药好像只能控制肌瘤不再长但是不能消除；经期是否也可服用？[第一段]     

桂枝茯苓胶囊治疗盆腔囊性占位6例

盆腔囊性占位以往大都认为来自附件，后经手术证实，有相当大一部分来自腹膜、肠系膜、阔韧带、圆韧带等而非附件，这些囊性占位有的能自行吸收而消失，有的则不能自行吸收，因此较大的（直径〉5cm）多采用手术治疗，较小的可以定期复查，一部分患者则因害怕手术而转为药物治疗。     

^1H-magnetic resonance spectroscopy screening for animals with acute cerebral infraction suitable forthrombolytic therapy

BACKGROUND: As a non-invasive technique which can provide comprehensive biological information, 1H-magnetic resonance spectroscopy (1H-MRS) may provide valuable reference data for irreversible recovery or reversible changes in ischemic tissue after stroke. OBJECTIVE: To monitor and evaluate the effect of the urokinase thrombolytic therapy after experimental acute cerebral ischemia by 1H-MRS technology and investigate its adaptability. DESIGN: Randomly controlled animal study. SETTINGS: Shenzhen Hospital of Peking University and National Key Laboratory of Pattern and Atom & Molecular Physics, Wuhan Physics and Mathematics Institute, Chinese Academy of Science. MATERIALS: Eleven healthy adult Sprague-Dawley (SD) rats, weighing 260–300 g and of both genders, were supplied by Experimental Animal Center of Tongji Medical Collage, Huazhong University of Science and Technology [SCXK (e) 2004-007]. 4.7T superconducting nuclear magnetic resonance meter was provided by Brucker Company. METHODS: The experiment was carried out in Shenzhen Hospital of Peking University and National Key Laboratory of Pattern and Atom & Molecular Physics, Wuhan Physics and Mathematics Institute, Chinese Academy of Science from August 2003 to December 2005. ① The rats were randomly divided into 30-minute self-thrombo-embolism group (n =6) and 60-minute self-thrombo-embolism group (n =5). Six rats in 30-minute self-thrombo-embolism group were occluded with clot embolus for 30 minutes and 5 rats in 60-minute self-thrombo-embolism group were occluded for 60 minutes. 10 000 U/kg urokinase was dissolved in 2 mL saline and the operation lasted for 5 minutes. ② 1H-MRS was performed before thrombolysis and at 3 hours and 24 hours after successful embolization. The metabolic changes of N-acetyl-L-aspartic acid (NAA)/phosphocreatine (PCr) + creatine (Cr), choline phosphate (Cho)/PCr+Cr and lactic acid (Lac)/PCr+Cr in the region of interests were analyzed. ③ The T2W image was conducted 24 hours after the thrombolytic therapy with TR=500 ms and TE=25 ms. ④ The subjects were sacrificed immediately after 1H-MRS and the brain tissues were cut into pieces and stained with HE method; in addition, pathological changes were observed under optic microscope. MAIN OUTCOME MEASURES: ① Metabolic changes of NAA/PCr+Cr, Cho/PCr+Cr and Lac/PCr+Cr in the region of interests; ② T2W image at 24 hours after the thrombolysis; ③ pathological observation of brain tissue. RESULTS: Eleven rats were all involved in the final analysis. ① Metabolic changes in the region of interests : In 30-minute self-thrombo-embolism group, the Lac peak emerged immediately after the embolism, but the ischemic zone decreased 3 hours after the thrombolytic therapy (0.252±0.01, 0.603±0.01, P < 0.01). Lac/(PCr+Cr) ratio was 0.290±0.01 at 24 hours after thrombolysis, which was higher than that at 3 hours after thrombolysis (P < 0.01). The NAA/ (PCr+Cr) ratio decreased significantly at 3 hours after the thrombolysis as compared with that before thrombolysis (0.922±0.16, 1.196±0.01, P < 0.05). In 60-minute self-thrombo-embolism group, the Lac/(PCr+Cr) ratio was higher at 3 hours after thrombolysis than that before thrombolysis (0.846±0.12, 0.601±0.11, P < 0.05) and the NAA/(PCr+Cr) decreased at 3 hours after the embolism. Fluctuation of NAA/ (PCr+Cr) ranged from 0.68 to 0.75 before thrombolysis and from 0.71 to 0.75 at 3 hours after thrombolysis. ② T2W image: T2W image showed that 2 subjects in 30-minute self-thrombo-embolism group whose Lac/NAA was higher than 0.7 suffered from intracranial hemorrhage. This meant that the subjects with Lac/NAA > 0.7 were more likely to suffer from intracranial hemorrhage. ③ Histological and morphological examinations: Optic microscope demonstrated that interspace surrounding nerve cells was widened at ischemic center; neurons were swelling; nucleus was stained lightly; pyknosis and mesenchymal edema were mainly observed in lateral cortex of brow and vertex and in lateral part of corpus striatum. CONCLUSION: ①Compound parameters in ischemic area before thrombolysis should be regarded as an important predicting marker for thrombolytic therapy, effect evaluation and termination. ② 1H-MRS combining with other imaging technique is a detecting way for screening cases who are suitable for thrombolytic therapy.