Opisthorchis viverrini： The carcinogenic human liver fluke

Opisthorchiasis caused by Opisthorchis viverrini remains a major public health problem in many parts of Southeast Asia, including Thailand, Lao PDR, Vietnam and Cambodia. The infection is associated with a number of hepatobiliary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis and cholelithiasis. Multi-factorial etiology of cholangiocarcinoma, mechanical damage, parasite secretions, and immunopathology may enhance cholangiocarcinogenesis. Moreover, both experimental and epidemiological evidences strongly implicate liver fluke infection as the major risk factor in cholangiocarcinoma, cancer of the bile ducts. The liver fluke infection is induced by eating raw or uncooked fish products that is the tradition and popular in the northeastern and northern region, particularly in rural areas, of Thailand. The health education programs to prevent and control opisthorchiasis are still required in the high-risk areas.     

Patient-reported outcomes in subjects with neuroendocrine tumors of the pancreas

AIM: To assess the patient-reported outcomes (PROs) of pancreatic neuroendocrine tumor (PNET) patients. METHODS: Fifty-one consecutive patients (21 male,30 female, 61.0 ± 10.3 years) with proven PNETs were studied. An SF-12 questionnaire capable of exploring the physical (PCS) and mental (MCS) aspects of daily life was used. Four questionnaires were also used [12 items General Health Questionnaire (GHQ-12) for nonpsychotic psychiatric disorders, State Trait Anxiety Inventory (STAI) Y-1 and Y-2 for anxiety and BDI-Ⅱ for depressive symptoms] to explore the psychological aspects of the disease. Forty-four sex- and age-matched Italian normative subjects were included and evaluated using the SF-12, STAI Y-1 and Y-2 questionnaires.RESULTS: Seven patients refused to participate to the study; they were clinically similar to the 44 participants who agreed to complete the questionnaires. PNET patients had a PCS score (44.7 ± 11.0) were not significantly different from the norms (46.1 ± 9.9, P = 0.610), whereas the MCS score was significantly lower in patients (42.4 ± 13.0) as compared to the norms (48.2 ± 9.8, P = 0.036). GHQ-12 identified 11 patients (25.0%) as having non-psychotic psychiatric disorders. The STAI scores were similar in the patients and in the normative population. Finally, BDI-Ⅱ identified eight patients (18.2%) with moderate depression and 9 (20.5%) with mild depression whereas 27 patients (61.4%) had no depression. CONCLUSION: The PNET patients had a good physical but an impaired mental component of their quality of life; in addition, mild or moderate depressive symptoms are present in about 40% of PNET patients.     

《中国医学文摘·肿瘤学》杂志更名为《中国癌症防治杂志》

经中华人民共和国新闻出版总署“新出报刊刊[2008]612号”文件批准,《中国医学文摘·肿瘤学》杂志更名为《中国癌症防治杂志》。更名后的《中国癌症防治杂志》为卫生部主管、由中国医师协会和广西肿瘤防治研究府联合主办的国家级综合性医药卫生类学术期刊。国内外公开发行。国内统一刊号：CN45-1366／R;国际标准连续出版物号：ISSN1674-5671。     

中心体在肿瘤发生及治疗中的作用

中心体维持细胞形态和染色体的准确分离,与损伤修复系统协同应对DNA损伤,维护基因组的稳定性。中心体结构或功能异常与非整倍体及肿瘤发生密切相关,抑制中心体蛋白可诱导肿瘤细胞凋亡,将成为肿瘤治疗的新策略。     

中医药应贯穿肿瘤姑息治疗的始终

"肿瘤"属中医之"积聚"、"噎膈"、"膨胀"、"痰核"等,其病因病机以外感六淫、内伤七情以及饮食劳逸不当所致的五脏六腑功能失调、气机阻滞、瘀血内阻等.姑息治疗是WHO肿瘤综合规划的四大任务之一,姑息治疗是一门多学科参与的针对有慢性的伴有威胁生命的疾病的患者进行治疗的一门特殊学科.姑息治疗医学是对那些对治愈性治疗不反应的患者安全的主动的治疗和护理、控制疼痛及有关症状,并对心理、社会和精神问题予以重视.其目的是为患者及家属赢得最好的生活质量.     

脑胶质瘤显微手术治疗78例临床分析

目的 分析显微外科手术治疗脑胶质瘤的临床疗效.方法 回顾性分析78例脑胶质瘤显微手术治疗的临床资料.结果 72例病人术前诊断与术后病理诊断符合率92.3%.经手术治疗显效38例(48.7%),有效35例(44.9%),无效5例(6.4%),治疗总有效率93.6%.结论 显微手术以其损伤小、适应证宽、全切除率高等优点,临床效果好.     

Research of cervical cytology screening in diagnosis of 370,000 cases with cervical lesion in Guangdong

Objective： Analysis of the results of 37 million cases by using cervical liquid-based cytology screening, discussion the situation of cervical cancer and precancerous lesions in Guangdong province. Methods： From 2002 to 2006, using liquid-based thin-layer cytology （TCT） method screening cervical lesions within 371,929 women in Guangdong. Cytological diagnosis adopt TBS （the Bethesda system） Standard （TBS improved 2001 version of the diagnostic criteria）, statistic positive rate by age and region respectively. Results： 371,929 cases of gynecology cervical samples in Guangdong, 331,251 cases were negative, accounted for 91.23%; cytology positive cases： 32,548 cases were squamous intraepithelial lesions （8.96%）, 486 cases were glandular epithelial lesions （0.13%）; grouped according to age： 30 to 40-year-old positive rate was 9.13%, 40 to 50-year-old positive rate was 9.60%, the latter had higher cytology positive rate; grouped according to region： the total samples in PRD areas were 304.951 cases, accounted for 81.99%, in which 24301 cases were positive （8.14%）, in 66978 cases （18.01%） of NON-PRD regions, 7645 cases were positive （11.87%）, there were 1858 cases had biopsy/follow-up results from 2004 to 2005, and the rate was 2.88%. Conclusion： The cytological positive rate of cervical cancer and its precancerous lesions was 9.09% in Guangdong （of which the rate of cytological diagnosis as precancerous lesions was 3.40%）, 30 to 50 age group had the high incidence of cervical cancer and its precursor lesions, and also the main stage of prevention for cervical cancer. Cytology positive rate was 11.87% in economic underdevelopment Non-Pearl River Delta regions, much higher than the Pearl River Delta region.     

Construction of eukaryotic expression plasmid pEGFP-N1-WWOX and its transient expression in SMMC-7721 cells

Objective： To construct eukaryotic expression plasmid pEGFP-NI-WWOX and transiently express it in SMMC-7721 cells. Methods： Total mRNA was extracted from normal human liver tissue. RT-PCR was used to amplify the aimed segments WWOX cDNA which was then digested with Hindlll and BamHI and inserted into a eukaryotic expression plasmid pEGFP-N 1 to construct pEGFP-N 1-WMVOX. The constructed plasmid was transfected into SMMC-7721 cells by lipofectamine 2000 - mediated transfer method. The expression of WWOX in transfected SMMC-7721 cells was detected 24, 36 and 48 h post-transfection with fluorescence microscope and the expression level of WWOX mRNA in transfected SMMC-7721 cells was assay by using RT-PCR. The change of MMWOX expression and cell proliferation rates were detected by immunocyto- chemistry and MTT methods respectively. Results： The results showed pEGFP-N1-WWOX was successfully constructed and expressed transiently in SMMC-7721 cells. At 48th hour post-transfection, the number of positive cells was increased significantly and much brighter green fluorescence could be detected, while no green fluorescence was detected in the control group. In SMMC-7721 cells transfected with pEGFP-NI-WWOX a high level of porcine WWOX was detected. WWOX ex- pressed by transfected cells could significantly inhibit the proliferation of SMMC-7721 cells. Conclusion： pEGFP-N1-WWOX was expressed successfully in SMMC-7721 cells, which suggested that might be used as a new therapeutic method for liver cancer.     

《中德临床肿瘤学杂志》2014年征稿启事

《中德临床肿瘤学杂志》是由中华人民共和国教育部主管,华中科技大学同济医学院主办的医学肿瘤学学术期刊（全英文月刊）,已先后被中信所科技核心数据库、中国期刊全文数据库、万方数据资源系统数字化期刊群、维普资讯网科技期刊数据库、中国学术期刊综合评价数据库、EMBASE、IndexCopernicus等国内外重要检索系统收录。国际、国内刊号为：ISSN1610—1979（纸质版）,1613—9089（网络版）;CN42—1654／R,邮发代号：38—121。     

第十五届全国临床肿瘤学大会暨2012年CSCO学术年会

<正>第十五届全国临床肿瘤学大会暨2012年CSCO学术年会将于2012年9月19～23日在北京市九华山庄举行,大会由中国抗癌协会临床肿瘤学协作专业委员会(CSCO)和北京市希思科临床肿瘤学研究基金会联合主办。本届年会将积极响应国家卫生部的号召,紧密围绕"推广国家规范,促进临床研究"的主题,开展多种形式的继续教育和学术交流活动。大会将鼓励和突出原创性研究报告,积极促进多中心协作临床研究和转化性研究;将邀请国内著名专家对国家卫生部新制定的常见肿瘤诊疗规范进行解读,大力推动临床肿瘤学多学科规范化综合治疗的进程。