文摘生活区

孕妇吃抗抑郁药新生儿会上瘾最新研究发现,孕妇服用抗抑郁药(如帕罗西汀、百优解等)会大大增加新生儿患上戒断症状的风险,其患病几率大约为1/3。以色列研究者对60名母亲孕期服用过抗     

认识抑郁症

抑郁症是一种心境低落性情感障碍 主要症状是“三低”（生活兴趣低落、情绪低落、精力下降），并且有焦虑濒躁、坐卧不安）。对一切都不感兴趣、失眠、厌食、情绪低落、精力下降，逐渐发展至暇性存下去都不感兴趣。有的伴有躯体症状如身体疼痛、头痛，性欲、食欲减退。     

鞘内注射吗啡加可乐定对切口痛大鼠脊髓背角蛋白激酶A催化亚单位表达的影响

Objective To observe the effect of intrathecal clonidine plus morphine on expression of protein kinase A (PKA) catalytic subunit in the spinal dorsal horn in a rat model of incisional pain. Methods Eighty male Sprague-Dawley rats were divided randomly into five groups: sham group, control group, pre-incisional morphine 2.5 μg group, pro-incisional clonidine 5 μg group and preincisional morphine 2.5 μg plus clonidine 5 lag group (n=16). lntrathecal catheter and the model of incisional pain were pro-duced according to Yaksh and Brennan's described method respectively. Changes of pain behavior were assessed by mechanical with-drawal threshold (MWT) and thermal withdrawal latency(TWL). The expressions of PKA catalytic subunit in the spinal dorsal horn were assessed by immunohistochemical method and western blotting analysis. Results Compared with sham group, MWT and TWL in control group were decreased significantly at 2 h after incision (P<0.01) and the number of positive cells and protein expression of PKA catalytic subunit in the spinal dorsal horn were increased significantly in control group (P<0.01). Compared with control group, MWT and TWL in pre-incision morphine 2 μg plus clonidine 5 lag group were increased significantly at 2 h after incision (P<0.01) and the number of positive cells and protein expression of PKA catalytic subunit in the spinal dorsal horn were decreased significantly in pre-incision morphine 2 μg plus clonidine 5 μg group (P<0.01). However, MWT, TWL and the number of positive cells and pro-tein expression of PKA catalytic subunit in the spinal dorsal horn changed with no statistical significance in pre-incisional morphine 2.5 μg group and pre-incisional clonidine 5 μg group compared with control group. Conclusion lntrathecal clonidine significantly enhances the antinociceptive effect of intrathecal morphine in a rat model of incisional pain, which might be associated with inhibi-tion of the increased expression of PKA catalytic subunit in spinal cord.     

胆囊切除术后致胆漏及胆肠内瘘医患纠纷分析

1案情及病史 某女，现47岁。11年前因患慢性胆囊炎、胆囊结石入住某医院，入院录显示：间歇性上腹疼痛10余年，频繁发作2年，B超提示胆囊炎、胆囊结石。于10月12日在持续硬膜外麻醉下行胆囊切除术，     

脉压与脉压指数在老年高血压疾病中的意义

多数研究表明,对于老年高血压而言,脉压较收缩压和舒张压更能反映大动脉僵硬度的变化,并与冠心病、脑卒中、心电图异常、心室肥厚等心血管事件呈显著相关。而脉压指数,综合了血管的动态顺应性和固有顺应性,是一项值得期待的评价血管硬化的新指标。     

腰椎穿刺置管持续腰池引流方法的改进

目的 观察改进后的持续腰池引流方法的效果,为降低引流并发症提供依据.方法 将72例蛛网膜下腔出血患者随机分为观察组和对照组各36例,对照组按常规方法行腰穿置管引流.观察组改进穿刺手法,用中心静脉导管置管,依次连接输液延长管、三通及引流袋.结果 两组置管引流时间比较,差异无显著性意义(P＞0.05).观察组堵管、疼痛发生率分别为0、2.78%,对照组分别为16.67%、28.57%,两组比较,差异有显著性意义(均P＜0.05).结论 改进后的腰池置管引流方法可减少引流管堵塞率、减轻患者局部疼痛.     

烧伤并发反应性精神障碍的护理对策

烧伤后单纯并发反应性精神障碍，在临床上并不多见，但一旦发生，如不及时控制精神症状，将会严重影响烧伤治疗。其主要原因烧伤是一种突发性的机体创伤，突如其来的创伤打击，使患者精神上难以承受，换药时强烈的疼痛刺激及生活习惯的改变，便使病人在身心两方面均受到重创，导致病人的情感、意识、偏离正轨而发病。     

药物转复室上性心动过速76例疗效观察

室上性心动过速是房窒结以上异位起博点发生快速异常冲动伴／不伴房室结析返或心肌旁道。大多数是阵发性室上性心动过速心电图表现为QRS波群形态正常，PR间期整齐。临床表现：突然发作伴有心悸焦虑不安、眩晕、心前区疼痛，直至发生舒张性心力衰竭或休克。我院2000年6月～2005年6月间门诊，住院经药物转复室上性心动过速41例76例次的临床资料，现报告如下。     

音频电针同步刺激并运动疗法治疗脑出血25例

观察音频电针同步刺激并运动疗法治疗脑出血的效果。25例患者均行脊柱和偏瘫肢体的音频电针同步治疗并运动疗法，1次／d，30min／次，10次／疗程。对偏瘫肢体的功能恢复，生活自理能力及肢体疼痛的改善有较好的效果。该方法是治疗脑卒中后遗症的有效方法之一。