枫蓼肠胃康胶囊联合曲美布汀与单剂曲美布汀治疗腹泻型肠易激综合征疗效比较

目的 观察枫蓼肠胃康胶囊联合曲美布汀治疗腹泻型肠易激综合征疗效.方法 将80例患者随机分为两组,治疗组(42例)予以枫蓼肠胃康胶囊、曲美布汀治疗.对照组(38例)单用曲美布汀治疗.两组疗程均为4周.结果 治疗组与对照组总有效率分别为80.9%与68.4%,治疗组疗效明显优于对照组(P＜0.05).结论 枫蓼肠胃康胶囊联合曲美布汀较单剂曲美布汀治疗肠易激综合征更有效.     

粘毛蓼脂溶性成分的GC-MS分析

目的:研究粘毛蓼的脂溶性成分。方法:采用索氏提取法提取脂溶性成分,用气相色谱-质谱法分析化学成分。结果:从粘毛蓼中分离得到44个化学成分,鉴定了其中的35个成分,占色谱总出峰面积的83.42%,主要脂肪酸为油酸,亚油酸和棕榈酸。结论:粘毛蓼脂溶性成分中主要为烷烃类成分(40.98%)和脂肪酸成分(29.01%),另外还含少量的植醇、甾醇类化合物。所得成分均为首次从本植物中发现。     

蓼属药物植物化学与药理

对蓼属拳参、何首乌、虎杖等药用植物的化学成分与药理作用的研究进行了综述。     

枫蓼肠胃康颗粒联合匹维溴铵片治疗腹泻型肠易激综合征临床研究

目的：观察枫蓼肠胃康颗粒联合匹维溴铵片治疗腹泻型肠易激综合征（D-IBS）脾胃湿热证的临床疗效。方法：选取104例D-IBS脾胃湿热证患者，采用随机数字表法分为治疗组与对照组各52例。对照组给予匹维溴铵片治疗，治疗组在对照组基础上给予枫蓼肠胃康颗粒治疗，2组均治疗8周。比较2组临床疗效、不良反应发生率，以及治疗前后中医证候积分与血清炎症因子[肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、白细胞介素-17 (IL-17)]水平。结果：治疗后，治疗组临床疗效总有效率98.08%，高于对照组82.69%(P<0.05)。2组腹痛、泻下不爽或急迫、胃脘胀闷、口臭口苦积分及总分均较治疗前降低（P<0.05），治疗组上述4项细则积分及总分均低于对照组（P<0.05）。2组血清TNF-α、IL-6、IL-17水平均较治疗前降低（P<0.05），治疗组血清TNF-α、IL-6、IL-17水平均低于对照组（P<0.05）。治疗期间，治疗组与对照组不良反应发生率分别为5.77%、7.69%,2组比较，差异无统计学意义（P>0.05）。结论：枫蓼肠胃康颗...     

基于网络药理学的头花蓼中槲皮素、没食子酸和槲皮苷对幽门螺杆菌胃炎以及胃癌治疗机制研究

目的 基于网络药理学的方法研究头花蓼对幽门螺杆菌胃炎以及胃癌的药理学机制，其中槲皮素、没食子酸和槲皮苷是头花蓼的主要活性成分。方法 通过PubChem、STITCH、SEA等8个数据库获取相关数据，并使用Cytoscape软件绘制蛋白-蛋白相互作用及头花蓼-化合物-预测靶点网络图。利用DAVID数据库对相关靶点进行GO和KEGG的富集分析，并应用AutoDock软件进行分子对接，以分析hub基因与其对应小分子的结合能。结果 网络药理学分析结果表明头花蓼对幽门螺杆菌胃炎以及胃癌的作用靶点共有27个，其中degree值前6的核心靶点和其相对应的化合物分子对接的结合能均小于0，且80%的最低结合能结果≤-5.0 kJ/mol。GO和KEGG的富集结果表明头花蓼可以调控炎症反应、细胞凋亡信号通路、TNF信号通路等生物学过程，能通过影响受体复合物、蛋白质异二聚体活性发挥作用。结论 头花蓼多靶点、多途径地作用于幽门螺杆菌胃炎以及胃癌，为头花蓼老药新用提供了新的依据。     

Mechanism of Polygonum capitatum in treatment of Helicobacter Pylori associated gastritis by network pharmacology,microarray data analysis and molecular docking北大核心CSCD

Aim To explore the mechanism of Polygonum capitatum(PC)in the treatment of Helicobacter Pylori associated gastritis(HAG). Methods The databases were used to identify the target of PC active compounds and HAG-related genes,and the intersection was taken to obtain the potential targets of PC treatment of HAG. The interaction network diagram of “drug-active compound-target-disease” and the protein-protein interaction(PPI)network of potential target protein interaction in HAG treated by PC were constructed by software Cytoscape 3.6.0. The important nodes in the network were screened by several topological indexes,and the GO and KEGG enrichment were analyzed by STRING database to obtain the potential signaling pathway of PC in the treatment of HAG. The binding ability of PC active components with key target proteins was observed by molecular docking method. On this basis,the related targets of PC in the treatment of HAG were verified in vivo and in vitro experiments. Results The PC active compounds and targets were identified through the database,and the “drug-active compound-target-disease” network diagram and the PPI network of potential target proteins were constructed. Combined with several topological indexes,the PPI network of potential target-protein interaction was analyzed,and 52 hub genes were screened. Further bioinformatics analysis and high-throughput sequencing revealed that PC exerted an effect on HAG through the Akt/NF-κB/NLRP3 pathway. Based on this,it was found that PC could reduce IL-18 and IL-1β in HAG GES-1 cells and HAG SD rats,up-regulate Akt and its phosphorylation level and reduce NF-κB expression,inhibit the activation of NLRP3 inflammatory body,so as to improve HAG inflammatory response. Conclusions PC could exert a therapeutic effect on HAG by activating Akt and its phosphorylation level,and inhibiting the expression of NF-κB and NLRP3 inflammasome related factors. This study provides a theoretical basis for explaining the mechanism of PC in the treatment of HAG. © 2023 Publication Centre of Anhui Medical University. All rights reserved.