Clinical benefit of gemcitabine plus cisplatin 3-week regimen for patients with advanced non-small cell lung cancer: a prospective observational study

Background Platinum-based chemotherapy has been proved effective in patients with advanced non-small cell lung cancer (NSCLC). This study evaluated the effectiveness and safety of first-line chemotherapy with gemcitabine plus cisplatin (GEM-Cis) 3-week regimen in routine care of Chinese patients with advanced NSCLC. Methods Two hundred and twenty-one patients with NSCLC stage IIIb or IV were enrolled and 209 were eligible for effectiveness and safety analysis. The median age was 58 (range 29 to 79) years. The percents of cases in stage Ⅳ and stage Ⅲb were 52.2% and 47.8%; of Karnofsky performance score (KPS) less than 80 and 80-100 were 37.3% and 62.7% and of adeno-cancer and non-adeno-cancer were 59.8% and 40.2%. The average number of completed chemotherapy cycles was three. Measures of effectiveness included clinical benefit, significant clinical response (SCR) and adverse effects of GEM-Cis in the treatment of NSCLC at stages Ⅲb/Ⅳ.Results KPS increased from 79±9 at baseline to 86±10 after chemotherapy (P<0.01). Lung cancer symptom scale (LCSS) score of pain, dyspnea and cough increased from 77±24, 74±22 and 63±19 to 92±15, 90±14 and 86±15, respectively (P<0.01). The clinical benefit rate was 85.2% ［95% confidence interval (CI) 80.3%-90.0%］. The SCR was 89.5% (95% CI 85.3%-93.7%). Median survival time was 7.8 months (95% CI 7.1 months-9.1 months). Sixty-four patients (30.6%) experienced an adverse effect that was deemed clinically significant. Only one patient (0.5%) was hospitalized due to chemotherapy related adverse effects. Life-threatening toxicity was observed in two patients (1.0%).Conclusion First-line chemotherapy with GEM-Cis in the routine care of Chinese patients with advanced NSCLC is effective and safe.     

更正

中医认为“臌胀”的发生多因情志郁结、酒食不节、劳欲过度、感染虫毒或黄疸、症积病后体虚所致肝、脾、肾脏腑功能失调．导致气滞、血瘀、水停于腹内而成。临床以乙型肝炎后肝硬化腹水为多见。由于本病临床症状复杂多变、病势深重、预后不佳。患者身心均承受着极大的痛苦。为了减轻患者的痛苦，减少或延缓并发症的发生，根据臌胀患者的特点，结合中医基础理论和中医整体护理观。从中医摄生角度以及健康的生活方式配合治疗，促使病情改善，并提高生活质量。     

冬季饮食“三加一”

冬季寒冷,自然界生机闭藏潜伏。中医《摄生消息论》对冬季保健有“调其饮食,适其寒温”的论述,提出冬季饮食“三加一”:即保温、御寒和防燥,附加是指进补。保温就是通过饮食以保持体温,即增加热能的供给,饮食中增加蛋白质的含量。据营养学研究,富含优质蛋白质的食物有肉类、蛋类、鱼类及豆制品等。优质蛋白质不仅营养价值高,而且易于     

针刺与治神

针刺防病治病 ,必以治神为先 ,神形并重。《内经》指出“针刺施术 ,必先从治神入手” ,以治神为本。《灵枢·本神》 :“凡刺之法 ,必先本于神”。《素问·刺真要太论》 :“针刺之要 ,必先治神”。《灵枢·九针十二原》 :“刺之要气至而有效”。《素问·上古天真论》有“形神合一”、“形与神聚”及“有诸内 ,必形诸于外”。中医在诊断、治疗、养生等方面也强调神的重要性 ,即“诊断贵察神 ,治疗本于神 ,摄生重在神”。1针刺中治神的理论基础1 1气血与形神的关系 :针刺作为一种刺激信号 ,通过激发人体固有调节机能 (气血运行 ) ,激发人体内的…     

彭祖摄生养性论

神强者长生，气强者易灭。柔弱畏威，神强也；鼓怒骋志，气强也。凡人才所不至而极思之，则志伤也；力所不胜而极举之，则形伤也。积忧不已，则魂神伤矣；积悲不已，则魄神散矣。喜怒过多，神不归室；憎爱无定，神不守形。汲汲而欲神则烦，切切所思神则败。久言笑则脏腑伤，久坐     

孙思邈论养性摄生及五脏情志病治

养性摄生和情志病脉辨治是孙思邈独特的学术部分，加以深入探讨对养生及情志疾病的辨治有重要意义。本文从注重情志症治，基于养性摄生；精神情志之疾，病涉五脏六腑；脏腑情志病症，治在舒心理脏的3个方面展开论述。     

摄生肝泰胶囊对肝损伤动物治疗作用的实验研究

中、大剂量摄生肝泰胶囊能显著地抑制四氯化碳（ＣＣｌ４）和Ｄ－胺基半乳糖（Ｄ－Ｇｌａ）所致急性肝损伤小鼠血清中谷丙转氨酶（ＡＬＴ）和谷草转氨酶（ＡＳＴ）的升高及总蛋白（ＴＰ）和白蛋白（ＡＬＢ）的下降,减轻肝组织的病理损害程度。各剂量摄生肝泰胶囊均能抑制ＣＣｌ４所致慢性肝损伤大鼠血清中ＡＬＴ和ＡＳＴ的升高,抑制ＴＰ和ＡＬＢ的下降及肝组织病理损害程度,且能降低肝组织中羟脯氨酸（ＨＹＰ）的含量。对免疫功能     

结合功能解剖学探讨针灸治疗慢性颈痛

基于功能解剖学探讨了慢性颈痛的发病机制、诊断、针灸治疗选穴及针刺操作、摄生调护。功能解剖学和传统针灸学对于慢性颈痛的认知存在共同点:两者均认为自身稳态的失衡是慢性颈痛的病机,在治疗上均强调恢复自身稳态的平衡。传统的慢性颈痛理论仅聚焦于导致颈痛的疾病,而功能解剖学则更关注其功能上的异常,更强调导致慢性颈痛的头颈部的力学失衡模式。功能解剖学相应的评估模式与治疗理念可应用于慢性颈痛的针灸临床治疗,协助指导穴位选择及揣穴,明确针刺操作方式及层次,把握疾病的标本关系,指导养生调护。故结合功能解剖学学科理论,可进一步完善针灸学对于慢性颈痛的认识,并提高临床疗效。     

佛经医理细品嚼明心见性身自安

佛教经典汗牛充栋,其中不乏摄生思想。“明心见性”即指清除内心所受世俗之尘的蒙蔽,恢复对自我本性的认识、理解和体验,以显现般若智慧。中医经典《黄帝内经》是中医学理论之渊薮,充满摄生之道。笔者撷取佛经、《内经》若干理论,旨在探索“明心见性”于养生的积极意义。?..     

论朝医独特的问诊

<正> 朝医是在朝鲜族固有文化及传统医药的基础上,吸收中医的理论,以"天、人、性、命"整体观为理论指导,以"四维之四象"结构为主要形式,以辨象论治为主要内容的一门独特的医学科学体系。朝医是辨四象以每象人的特点选择用药,因此问诊具有独特的特点。问诊主要询问4个方面即健康及病态时特征、心理状态、摄生嗜好及药物史、易感特