湛江市260名健康成人尿δ—ALA参考值上限的探讨

湛江市２６０名健康成人尿δ—ＡＬＡ参考值上限的探讨湛江市职业病防治所（霞山录塘路，５２４０１８）赵南广东医学院中心实验室唐旭东铅接触工人尿中δ－氨基酮戊酸（δ－ＡＬＡ）含量变化较早，有一定特异性，其含量增高可反映铅接触和中毒程度。另外，δ－ＡＬＡ仍是...     

十二烷氮酮氟尿嘧啶凝胶治疗疣及银屑病150例

443例(男225例,女218例;年龄36±14a)皮肤病患者,其中150例(扁平疣52例、寻常疣55例、银屑病43例)外用含1.8％十二烷氮(艹卓)酮的1％氟尿嘧啶(5-FU)凝胶作为治疗组,148例外用1％5-FU凝胶及145例外用2.5％5-FU霜作为2个对照组。经双盲对照临床试验,结果表明含1.8％十二烷氮(艹卓)酮的1％5-FU凝胶的疗效明显优于2个对照组(P<0.01及P<0.005)。证明氮(艹卓)酮对5-FU确有渗透促进作用。     

Rapid effect of stress concentration corticosterone on glutamate receptor and its subtype NMDA receptor activity in cultured hippocampal neurons

Objective: To study the rapid effect of glucocorticoids (GCs) on NMDA receptor activity in hippocampal neurons in stress and to elucidate its underlying probable membrane mechanisms. Methods: Whole-cell patch-clamp recording was used to assess the effect of stress concentration corticosterone (B) on the responses of cultured hippocampal neurons to glutamate and NMDA (N-methy-D-asparatic acid). To make clear the target of B, intracellular dialysis of B(10μmol/L)through patch pipette and extracellular application of bovine serum albumin-conjugated corticosterone (B-BSA, 10μmol/L)were carried out to observe their influence on peak amplitude of NMDA-evoked current. Results: B had a rapid, reversible and inhibitory effect on peak amplitude of GLU-or NMDA-evoked current in cultured hippoeampal neurons. Furthermore, B-BSA had the inhibitory effect on INMDA as that of B, but intraeeUularly dialyzed B had no significant effect on INMDA. Conclusion: These results suggest that under the condition of stress, GCs may rapidly, negatively regulate excitatory synaptic receptors-glutamate receptors (GluRs), especially NMDA receptor (NMDAR) in central nervous system, which is mediated by rapid membrane mechanisms, but not by classical, genomic mechanisms.     

贯叶金丝桃对戒烟者的Ⅱ期临床研究

贯叶金丝桃与安非他酮的作用机制相似，即降低神经递质多巴胺、5-羟色胺和去甲肾上腺素的再摄取。由于安非他酮可使戒瘾速度加倍（与安慰剂相比），推测贯叶金丝桃是可用于戒烟的新药，而这方面研究鲜有报道。为此作者进行了此项Ⅱ期临床研究，以评价贯叶金丝桃对戒烟者的有效性。     

普罗帕酮治疗阵发性室上性心动过速50例临床分析

阵发性室上性心动过速（PSVT）是一种阵发性快速而规则的异位心律，是临床上常见的心律失常之一，可引起心悸、乏力、胸闷、头晕、晕厥等症状，对持续发作或有器质性心脏病者应采取必要措施，尽早控制其发作。本科从2003年9月-2005年6月应用普罗帕酮治疗50例PSVT病人取得满意疗，效报告如下。