FDG-PET/CT在诊断肺癌中的应用近况

长期以来，肺癌的诊断是依靠X线胸片，CT和MRI来完成。但是由于分辨率的限制，对微小病变定性困难。PET／CT是当今最先进的医学影像诊断技术之一．其优点是一次性可完成全身检查，发现全身任何组织器官的原发肿瘤及转移病灶，准确提供肿瘤部位、大小与周围组织器官关系，同时在分子水平将肿瘤发生发展过程中的代谢变化以图像的方式显示，将细胞代谢变化与组织结构改变合二为一．构成立体三维图像。在肺癌诊断中可早期发现敏感微小癌，可准确鉴别肿瘤和淋巴结良恶性质，并可评价治疗效果。检查安全，无疼痛不快，不受衣物等外界物质干扰。对肺癌的诊断和分期有很高的敏感性、特异性和准确性。     

病残儿童遗传病的季节性分析及优生措施的落实

目的观察遗传病与季节性变化关系，对提高人口素质，实行优生优育，防止和降低出生缺陷具有十分重要意义。方法医学鉴定小组对陆良县1999～2004年申报的68例病残儿材料进行初审鉴定，详细进行病残儿家庭遗传病咨询、问卷调查，对21种疾病发病季节性进行分析，部分病残儿及父母做染色体G显带技术核型分析。结果大多数遗传病与季节无显著关系，而少部分如多基因遗传病中腹股沟斜疝、先天性髋关节脱位、先天性聋哑、先天性足畸，染色体病中21三体综合征发病具有季节性关系。结论遗传病发病季节性探讨分析，不仅是人口生命质量的提高，而且是病因学，流行病学研究的第一步，越来越引起社会和人们的重视。     

围绝经期妇女性激素水平的变化

为使广大妇女能安全的渡过围绝经期，避免或减少围绝经期综合征的发生，提高其生活质量，探讨围绝经期妇女性激素变化与临床表现的关系并及早作出诊断。现对2006年1月～2007年1月来在全市6所三级以上医疗保健机构妇产科就诊的368例45．55岁的妇女进行性激素6项检查，现将结果报告如下。[第一段]     

试论手法之补泻及其辨证应用

本文通过古代文献论述以及现代研究,提出了手法补泻的方向、缓急、轻重、时间、手法和受力部位和特性的六个影响因素,并以以"三因制宜"为纲,从因地、因时、因人的年龄、性别、体质、所患疾病、病情变化、脏腑功能、耐推拿程度以及心量状况的不同等十个方面论述手法之补泻的临床辨证施用.     

优化商品陈列 刷新销售业绩

研究表明：商品陈列面的大小变化、化妆品陈列的高低变化和化妆品的陈列时间等均会影响化妆品店的销售额。首先，商品陈列面的大小变化会引起销售额的变化。如由4个货位减少到2个货位，销售额锐减48％；由3个货位减少到1个货位，销售额锐减68％；由2个货位增加到4个货位，销售额增加40％。所以，在化妆品店的商品陈列中，要加大购买频率较高品种的陈列面，并以大陈列面形成聚焦点，刺激顾客购买。     

血透患者中枸橼酸西地那非的药代动力学及血流动力学变化

患有肾病的男性中ED发病率很高。枸橼酸西地那非是勃起功能障碍的高效治疗药物，严重肾功能不全会使该药清除率下降，但在血透治疗的终末期肾病患者中，该药的药代动力学和血液动力学研究尚未见报导。为了研究血透患者中，该药的药代动力学和血流动力学变化，Grossman EB等人让15例慢性门诊血透维持患者在血透前2h及血透后2h口服单剂西地那非，先服哪一次进行随机分配确定。     

Changes in T .lymphocyte subsets after severe traumatic brain inJury

BACKGROUND： Besides local changes of cranial parenchymal cells, hemorrhage, etc., severe traumatic brain injuries also cause the changes of total body fluid and various functions, and the changes of lymphocytes and T lymphocyte subsets should be paid more attention to. OBJECTIVE： To reveal the changing laws of T lymphocyte subsets after severe traumatic brain injury, and compare with mild to moderate brain injury. DESIGN： A comparative observation. SETTINGS： Department of Neurosurgery, Longgang District Buji People＇s Hospital of Shenzhen City; Central Laboratory of Shenzhen Hospital of Prevention and Cure for Chronic Disease. PARTICIPANTS： All the subjects were selected from the Department of Neurosurgery, Longgang District Buji People＇s Hospital of Shenzhen City from August 2002 to August 2005. Thirty patients with severe brain injury, whose Glasgow coma score （GCS） was ≤ 8 points, were taken as the experimental group, including 21 males and 9 females, aging 16 - 62 years. Meanwhile, 30 patients with mild traumatic brain injury were taken as the control group （GCS ranged 14- 15 points）, including 18 males and 12 females, aging 15 -58 years. All the subjects were in admission at 6 hours after injury, without disease of major organs before injury Informed consents were obtained from all the patients or their relatives. METHODS： （1） The T lymphocytes and the subsets in peripheral blood were detected with immunofluorescent tricolor flow cytometry at l, 3, 7 and 14 days after injury in both groups. （2） The conditions of pulmonary infections were observed at 4 days after injury. The differences of measurement data were compared with the t test. MAIN OUTCOME MEASURES： Changes of T lymphocytes subsets at 1 - 14 days after severe and mild or moderate traumatic injury. RESULTS： Finally, 28 and 25 patients with mild to moderate traumatic brain injury, whereas 25 and 21 patients with severe traumatic brain injury were analyzed at 7 and 14 days respectively, and the missed ones died due to the development of disease. （1） Changes of T lymphocyte subsets： At 1 and 3 days after injury, CD3, CD4, CD8, CD4/CD8 began to decrease, whereas CD8 increased in the experimental group, which were very significantly different from those in the control group （t =2.77 - 3.26, P 〈 0.01）, and began to recover at 7 days, which were significantly different from those in the control group （t = 2.06 - 2.24, P 〈 0.05）, and generally recovered to the normal levels at 14 days （P 〉 0.05）. （2） Conditions of pulmonary infections： At 4 days after injury, the rate of pulmonary infection was significantly different between the experimental group and control group [73% （22/30）, 0, x2=37.29, P 〈 0.01]. CONCLUSION： Patients with severe traumatic brain injury suffer from damages of cellular immune function at early period （within 7 days）, and they are easily to be accompanied by pulmonary infections.     

复合矫治弓丝接头的力学性能及接头组织观察

目的　测试复合矫治弓丝接头的机械性能及分析接头、接头断口变化。方法　测试复合矫治弓丝接头的拉伸强度、剪切强度、扭转强度、弯曲形变残余角,TiNi形状记忆合金丝超弹性,扫描电镜观察及分析接头、断口组织变化。结果　复合矫治弓丝接头抗拉伸强度为32 0～36 0MPa ,剪切强度为2 2 0～2 5 0MPa ,抗扭转强度为30～4 0N·m、断裂时扭转角度不小于1 4 4 0°,弯曲形变残余角为1 2～1 7°;钎焊异质接头中TiNi形状记忆合金丝超弹性几乎没有破坏;接头钎料与TiNi形状记忆合金界面不存在扩散层,与不锈钢丝界面之间有一较宽的扩散层,接头断裂多发生在钎料与TiNi形状记忆合金超弹界面处,部分发生在钎缝中心。结论　复合矫治弓丝机械性能符合正畸临床要求,可应用于临床。