托吡酯治疗婴儿痉挛症47例疗效观察

1资料与方法1.1病例选择标准(1)符合1989年国际抗癫联盟关于癫与癫综合征分类中婴儿痉挛症(West综合征)的定义;(2)影像学异常,有明确原发病诊断或伴有发育障碍、智力低下,尚未找到原发病者以隐源性癫痫纳入;(3)家长对本研究了解、同意加入此项研究。1.2一般资料按照以上标准选取婴儿痉挛症患儿75例,男42例,女33例,年龄(6.8±3.4)个月,日平均发作频率(40±32)次。其中新诊断组56例随机分为治疗组,28例,对照组28例,两     

Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes

The role of aquaporin-4 in water transport has been extensively investigated, while little information exists regarding its contribution to astrocytic functions such as the action to glutamatergic transmission. Since aquaporin-4 has been detected widely co-localized with glutamate transporter 1 （GLT-1） and glutamate transporters also present water transport properties, we investigated the regulative role of aquporin-4 on glutamate transporter using primary cultured astrocytes from aquaporin-4 knockout[AQP4（-/-）]mice.     

托吡酯对重症病毒性脑炎患儿的神经保护作用

目的观察托吡酯（TPM）对重症病毒性脑炎患儿血清和脑脊液神经元特异性烯醇酶（NSE）的影响,探讨TPM对重症病毒性脑炎患儿的神经保护作用。方法对34例重症病毒性脑炎患儿,随机分为TPM治疗组20例和常规治疗组14例,采用放免分析法法测定两组患儿治疗前及治疗后7d、14d血清、脑脊液NSE水平,并与正常对照组15例比较。结果TPM治疗组治疗7dNSE明显下降,与常规治疗组有显著差异;治疗14dTPM治疗组与正常对照组无显著差异,常规治疗组仍高于正常对照组,且有显著性差异。结论TPM能够有效降低重症病毒性脑炎患儿血清和脑脊液NSE水平,可能对神经具有保护作用。     

口腔喷雾剂用前要呼气

如今，一些口腔喷雾剂型的药物，以其方便，快捷，见效快等特点，深受患者喜爱。如治疗心绞痛的硝酸异山梨酯口腔喷雾剂、治疗哮喘的异丙肾上腺素喷雾剂等。不少人在使用时，都是把喷雾剂向嘴中连喷数下。北京协和医院药剂科主任药师张继春表示，这样使用不正确。     

胃克宁胶襄及其各组分对大鼠乙酸性胃溃疡及幽门螺杆菌的影响

采用大鼠乙酸性胃溃疡模型,观察胃克宁胶囊及其各组分,即土霉素、丙胺太林呋喃唑酮及法莫替丁的抗溃疡作用.结果显示.溃疡抑制率分别为82.6%、32.1%、45.5%、50.6%、59.6%.胃克宁胶囊的抗溃疡作用明显优于各组分及法莫替丁.体外抑菌试验证明,胃克宁胶囊对幽门螺杆菌(HP)的抑制作用优于丽珠得乐、丙胺太林和呋喃唑酮.胃克宁胶囊的抗溃疡作用及抗HP的作用优于单药.     

双氢青蒿素对恶性疟原虫有性生殖期的影响

Eighteen falciparumn malaria patients with gametocytemia were randomly allocated to 2 groups,treated respectively with dihydroartemisinin (DATM) tablets at a total dose of 360 mg over 5 days and with oral quinine sulfate (QN) at a total dose of 10 5000 mg over 7 days. Peripheral gametocyte counts were done daily in all patients until its disappearance. Blood samples were taken on D0, D4, D7, D10, D14, D21 and D28 from the patients to perform infectivity tests to Anopheles dirus. The result showed that the mean clearance times of PFG were 21.8±5.2 days in DATM group and 31.5±8.7 days in QN group respectively. And in DATM group, the infectivity tests were positive in 6 cases only. In those 6 positive cases, the numbers of the positive infectivity on D4, D7, D10, D14 and D21 were 6/6,6/6,2/6,0/6 and 0/6 respectively. While the 4 negative cases on D0 remained negative infectivity on D4, D7, D10, D14. In QN group, the infectivity tests were positive in 4 cases too on D0, the numbers of positive cases on D4, D7, D10, D14, D21 and D28 were 8/8,8/8,8/8,8/8,2/8 and 0/8 respectively. These indicate that QN cannot inhibit P.Falciparum at sexual stage, while DATM has a remarkable inhibitory effect, and may prevent the immatured PFG that was failure to infect An. dirus on D0 from maturing.     

D—聚甘酯在各脏器的分布特点及其透过血脑屏障机制的研究

利用＾３Ｈ标记Ｄ－聚甘酯,观察了小鼠口服Ｄ－聚甘酯后在各组织和器官尤其是脑的分布特点,并对春血脑屏障的机制进行了初步探讨。实验结果显示,Ｄ－了矣甘酯可以迅速透过血脑屏障,并且除肾脏外,其在脑中的显著性地高于其他组织与器官。Ｄ－聚甘酯在中脑的２显著的高于脑的其他部位。给药３ｈ以后,脑内的Ｄ－聚甘酯９５．８％以原形存在。给小鼠等量的＾３Ｈ－Ｄ－聚甘酯和不同量的Ｄ－聚甘酯,随着Ｄ－聚甘酯量的增加,脑内的     

7-羟基黄酮衍生物的合成

以具心血管活性的7-羟基黄酮为底物,分别与阿魏酸、烟酸、对氯苯氧异丁酸成酯,合成了三个新化合物,其结构经1H NMR、MS和IR确证.     

关于单硝酸异山梨酯片的研制

本文从化学结构,生产工艺、药代动力学、 药效等几方面阐述了单硝酸异山梨酯片的特点。     

肾移植术后霉酚酸酯的应用及其临床意义

霉酚酸酯(Mycophenolate Mofetil, MMF)是霉酚酸(Mycophenolicacid, MPA)的2-乙基酯类衍生物,为前体药.MMF是新一代的免疫抑制剂,特异性作用于淋巴细胞,与其它免疫抑制剂联用(除硫唑嘌呤:AZa外)防治肾移植术后的排异反应,作用确切,可挽救皮质类固醇、抗淋巴细胞抗体治疗的难治性排异反应,收到满意的临床效果.MMF口服后生物利用度高,药物耐受性好,无肝肾毒性,不抑制骨髓,无高血压、糖尿病、胰腺炎等副作用,不良反应少.自1996年问世以来,国内外专家都肯定了MMF在临床的疗效和价值,受到医生和患者的欢迎.