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排序方式: 共有1035条查询结果,搜索用时 15 毫秒
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M. KROTKIEWSKI L. SJ
STR
M L. SULLIVAN P.-A. LUNDBERG G. LINDSTEDT H. WETTERQVIST P. BJ
RNTORP 《Journal of internal medicine》1984,216(3):269-275
Abstract Thyroid hormones were measured before, during and after acute exercise (60 min) or physical training (3 months) in obese women. Thyroid stimulating hormone concentration increased during acute work and decreased immediately after. No changes were seen during the two following days. An increase was seen after ten days as well as after three months of physical training. Thyroxine concentrations showed no changes. 3,5,3′-Triiodothyronine decreased slightly immediately after acute exercise, and after three months of physical training, 3,3′,5′-triiodothyronine (reverse triiodothyronine) increased slowly during and after acute exercise. A negative correlation was found between changes in fasting insulin and thyroxine and a positive correlation between changes in blood pressure and triiodothyronine after training. Lack of agreement in previous reports is probably due to methodological differences such as methods more or less susceptible to fatty acid interference, and thyroid hormones changing differently during acute work and before and after physical training. The duration of the study may also be of importance, even 3 months possibly being too short for attaining equilibrium in thyroid homeostasis. 相似文献
3.
Antonio Porcellini Gianfranco Fenzi E. V. Avvedimento 《Journal of molecular medicine (Berlin, Germany)》1997,75(8):567-575
Thyrotropin is the primary pituitary hor- mone which stimulates the growth and differentiation of thyroid cells. TSH binds
a specific receptor present in the plasma membrane of thyroid cells and signals the G protein transducers, which activate
different effec- tors, mainly adenyl cyclase and phospholipase C. The TSH receptor belongs to a broad class of receptors known
as seven-loop receptors because they contain a long stretch of amino acids which cross the plasma membrane seven times. Mutations
in the TSH receptor gene have been found in hyperfunctioning thyroid adenomas. These mutations are: (a) somatic (present only
in the tumor), (b) dominant (only one copy of the gene is affected), and (c) lead to the constitutive activation of the cAMP
signaling cascade. Most mutations which have been identified occur in the intracellular loop III and in the transmembrane
domain VI. Germline mutations in the same regions of the receptor have been found in congenital nonautoimmune hyperthyroidism.
In addition, germ line mutations have been described in the extracellular domain of the receptor leading to increased TSH
levels. The clinical implications of these findings are discussed.
Received: 15 January 1996 / Accepted: 8 March 1996 相似文献
4.
Yusuf Orhan Adil Azezli Mahmut Çarin Ferihan Aral Ergin Sencer Senay Molvalılar 《Journal of clinical immunology》1993,13(5):339-343
To evaluate the association of HLA types with Turkish patients with Graves' disease, HLA typing, clinical findings, and thyroid antibodies were correlated. The HLA types, clinical findings (ophthalmopathy and age at onset), and thyroid stimulating hormone (TSH) receptor (TRAb) and antithyroid microsomal antibodies (MAb) were analyzed. Seventy Turkish patients with Graves' disease and 306 control subjects were assessed. Serological HLA typing was performed in HLA A, B, C, DR, and DQ loci. There was a significantly increased prevalence of HLA B8, B49, DR3, DR4, and DR10 in Graves' disease. The association of Graves' disease with HLA DR3 was found to be less strong than previously described. The HLA DR4 antigen may contribute to the predisposition of Graves' disease in Turkey. The results suggest that HLA B7, B13, DR7, DQw2, and DQw3 may confer a protective effect for Graves' disease in Turkey. Patients carrying HLA B12, B18, and B44 haplotypes had a tendency to develop the disease at a later age. The difference from the other studies may be the result of the selection of the controls; in part, of the variability in serological typing reagents; and, also, of the rather weak HLA associations with the disease.This study was presented in part at the Annual Meeting of the National Endocrinology and Diabetes Association, Bursa, Turkey, May 25–28, 1992. 相似文献
5.
根据自身免疫性甲状腺疾病发病机制的独特型-抗独特型免疫免疫学说,用兔抗人TSHAb检测TSH抗独特型抗体(TSHAb2)。以正常人为对照,以其结合率^-x+2s为正常值上限,大于此值为阳性。60例TRAb阳性病人,65%病人TSHAb2阳性,而40例TRAb阳性病人中,只有5%病人TSHAb2阳性。两组差异显著(P〈0.05)。TRAb和TSHAb2呈正相关(r=0.645,P〈0.01)。同时用 相似文献
6.
Csaba M. Banki Maria Vojnik Mihaly Arato Zsuzsa Papp Zsuzsa Kovacs 《European archives of psychiatry and clinical neuroscience》1985,235(1):32-37
Summary Baseline and TRH-induced changes of thyroid stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH) were measured in 15 healthy control subjects and 63 psychiatric inpatients with DSM-III diagnoses of major depression (n = 19), schizophrenic disorder (n = 20), alcohol dependence (n = 10), and adjustment disorder (n = 14); baseline and postdexamethasone cortisol (CS) were also determined 3–6 days after the TRH-challenge. All patients and controls were women of similar mean age, weight, height, and they were free from interfering illness or drugs.Baseline TSH and PRL were lower in depression, TRH-induced TSH and PRL responses were lower in the whole patient group, but most markedly in depression and alcohol dependence. Postdexamethasone CS was significantly higher in depression, schizophrenia and alcohol dependence. Basal GH did not differentiate the subgroups; TRH-induced pathological GH responses were sometimes found in the patient groups. The differences were most marked quantitatively in major depression: a multivariate analysis of variance showed that TSH, postdexamethasone CS and PRL were the most important variables in separating patients from controls. A discriminant function derived from these variables classified all controls and 18 of 19 depressed patients correctly; however, 25 of the 44 other patients were also classified with depression.It was confirmed that psychiatric patients show significantly more endocrine disturbances than controls, and this was seen not only in major depression but also in at least three other conditions. Further work is needed to identify other neuroendocrine patterns more specific to depressive disorder. 相似文献
7.
目的:鉴别甲亢型桥本甲状腺炎( H T)和 Graves 病( G D),提高 H T 的诊断率,减少 H T 手术和不必要的抗甲状腺治疗。方法:以经甲状腺细针穿刺活检或术后病理证实为 H T 和 G D 的临床表现为甲状腺功能亢进的病人为研究对象,以活检前或术前清晨空腹血清 T G A, T M A, T3, T4 和 T S H 为检测指标。结果:甲亢型 H T 和 G D 病人的 T G A, T3 有明显差异( P< 001); T3/ T4, T M A, T S H 有显著差异( P< 0001); T4 无差异( P> 005)。结论:血清 T3, T3/ T4 , T S H, T G A 和 T M A 可以作为鉴别甲亢型 H T 和 G D 的重要检测指标。 相似文献
8.
Goichot B Brandenberger G Saini J Wittersheim G Follenius M 《Journal of sleep research》1992,1(3):186-190
SUMMARY The thyrotropin (TSH) nycthemeral pattern is known to be strongly influenced by sleep, but previous studies have failed to demonstrate any link between sleep structure and TSH variations. Using 10-min blood sampling, nocturnal TSH profiles were analysed in 24 young healthy subjects during normal sleep. Six of the subjects then underwent a partial sleep deprivation experiment, sleep was permitted from 03.00 hours to 07.00 hours. Descending slopes of TSH values were observed for the first 20 minutes of SWS episodes, whereas no significant trend was found for other sleep stages. During the period of sleep deprivation, nocturnal TSH levels increased and then declined immediately after sleep onset; however, the association between SWS and descending TSH slopes persisted. This temporal concordance suggests that some particular mechanisms associated with SWS may modulate TSH release, or conversely that increasing TSH levels prevent the occurrence of SWS. 相似文献
9.
目的了解临沂市新生儿碘营养状况.方法于2002年3~5月在全市范围按PPS(组群抽样)法抽取30个点,检测新生儿脐带全血促甲状腺激素(TSH)水平.结果检测新生儿脐带血862份,TSH中位数为3.535 mU/L,>5 mU/L的脐血样品数占31.7%,与1995年(41.4%)相比有所下降(P<0.05),但仍远高于"新生儿TSH>5 mU/L的比例<3%"的碘缺乏病消除标准.同时发现新生儿TSH水平与8~10岁儿童甲状腺肿大率及尿碘水平存在着严重分离现象.结论临沂市新生儿碘营养状况有所改善,但仍存在碘营养不足.建议加强对孕妇等待需人群的补碘工作,并尽快研究出与国际接轨的新生儿脐带血TSH切点值. 相似文献
10.
Amparo Rodríguez Sánchez María J. Chueca Guindulain María Alija Merillas Susana Ares Segura José Carlos Moreno Navarro María Dolores Rodríguez Arnao 《Anales de pediatría (Barcelona, Spain : 2003)》2019,90(4):250.e1-250.e8
The screening program of congenital hypothyroidism (CH) is probably one of the best achievements in paediatrics. Thyroid hormones are essential for brain development and brain maturation that continue through the neonatal period. Hypothyroidism that begins in the first months of life causes irreversible damage to the central nervous system, and is one of the most frequent and preventable causes of mental retardation. As children with congenital hypothyroidism are born with a normal appearance, analytical studies are required to immediately start the appropriate therapy.This article analyses the aims, diagnostic procedures, tests required, aetiology, and differential diagnosis in this disorder. Especially relevant is to perform frequent monitoring to ensure dose adjustments of L-Thyroxine therapy, avoiding infra- or supra-dosing that negatively affects neurosensory functions. Re-evaluation of the aetiology permanent vs transient hypothyroidism is always recommended after 3 years of chronological age.The relevance of this screening program should be widely discussed in paediatrics. The main objective is to avoid cerebral damage in these patients, and has been highly successful and economically beneficial.Other aspects are required to optimise patient outcomes, to perform all the controls according to the recommendations and to include, in the near future, the diagnosis of central hypothyroidism. Implementation of this program is necessary to progress in accordance with current scientific knowledge. 相似文献