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51.
Hepatocyte isolation from pig livers after warm ischaemic injury 总被引:9,自引:0,他引:9
Michael R. Schön Gero Puhl Jörg Gerlach Jorn Frank Peter Neuhaus 《Transplant international》1994,7(S1):159-162
Abstract Hepatocyte cultures have been used extensively for a wide variety of physiological, pharmacological and experimental studies. The warm ischaemic period before isolation is kept to a minimum to achieve a high yield of cells isolated and a good viability for culture. We have recently introduced a new concept of liver resuscitation after warm ischaemia that is based on a 3-h reperfusion period with an improved perfusate and simultaneous dialysis. In this study, we applied the new technique for hepatocyte isolation from livers subjected to 80 min of complete ischaemia at 37 °C. Cell yield was improved by a resuscitating perfusion from 58% to 73% and viability from 39% to 76%. 相似文献
52.
Rianne Bindels Arie Hasman Mieke Derickx Jan W J Van Wersch Ron A G Winkens 《International journal for quality in health care》2003,15(6):501-508
OBJECTIVE: The GRIF automated feedback system produces real-time comments on the appropriateness of diagnostic tests ordered by general practitioners (GPs) based on recommendations from accepted national and regional practice guidelines. We investigated the experiences of GPs with this system and, more specifically, with the recommendations produced by the system as well as their views on using this system in daily practice. SETTING: We tested the GRIF system in an experiment in a laboratory setting and in a daily practice trial. STUDY PARTICIPANTS: General practitioners. INTERVENTION: In the laboratory experiment, GPs used the GRIF system to assess the appropriateness of 30 request forms. Each of the GPs was confronted with requests they had submitted to the diagnostic unit of the hospital in the past. In the field trial, the GRIF system was applied during patient consultations for 1 year. MAIN OUTCOME MEASURES: We measured GPs' satisfaction with the system using a questionnaire, and also conducted group discussions (in the laboratory experiment) and in-depth interviews (in the field trial) to elicit GPs' opinions of and experiences with the system. In addition, we explored GPs' reasons for not accepting the comments offered by the GRIF system. RESULTS: The results show that the GPs in the laboratory experiment had more positive attitudes towards the system compared with participants in the field trial. All discussion groups and most of the GPs in the field trial regarded receiving the immediate feedback during the test ordering process as an important advantage. The most frequently mentioned reason to reject the recommendation was disagreement with the content and/or the recommendations in the practice guidelines. CONCLUSION: Apart from securing agreement on guideline content, a prerequisite for using GRIF in daily practice on a large scale is that more attention is paid to promotion of the guidelines and their adoption, and stimulation of a positive attitude towards the practice guidelines among the users. 相似文献
53.
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55.
E. Van de Keift K. De Boulle P. Willems J. -J. Martin P. Selosse B. Van der Auwera 《Acta neurochirurgica》1992,117(3-4):172-177
Summary Inactivation of tumour suppressor genes or anti-oncogenes as well as activation of dominant acting oncogenes seem to be important mechanisms in the pathogenesis of gliomas. We compared constitutional and tumoural genotypes at different restriction fragment length polymorphism loci (RFLP) on chromosomes 10 and 17 in 15 unrelated individualsLoss of heterozygosity (LOH) pointing to chromosomal loss or deletions was detected for at least one chromosme 17 marker in 11 gliomas (astrocytomas grades I–III and glioblastoma multiforme), whereas LOH for chromosome 10 loci was only detected in 3 out of 9 cases of glioblastoma multiforme and was not detected in low grade gliomas. Since LOH for chromosome 10 loci seems to be restricted only to glioblastoma multiforme, it is possible that recessive mutations on chromosome 10 are engaged in tumour progression from astrocytomas to glioblastoma multiforme. As LOH of chromosome 17 markers occurs in astrocytomas as in glioblastoma multiforme, chromosome 17 loci probably are involved in early tumour development. 相似文献
56.
应用修正正交分段线性函数的时滞和反向特性,推导出求解时滞系统和卷积的公式。数字仿真表明,它具有计算简单,精度高的优点。 相似文献
57.
本文详细介绍了在新疆发现的花蠕形蚤、叶氏蠕形蚤、北山羊蠕形蚤、羊长喙蚤和狍长喙蚤的形态学特点、地理分布和某些生物学特性。 相似文献
58.
LISS钢板治疗股骨远端粉碎骨折的疗效分析 总被引:1,自引:0,他引:1
目的探讨应用微创固定系统LISS钢板治疗股骨远端粉碎骨折的临床疗效。方法采用LISS钢板治疗股骨远端粉碎骨折26例。结果所有患者获得10—28个月随访,切口Ⅰ期甲类愈合,骨折全部愈合,X线复查骨折对位、对线良好,未发生感染,无内固定钢板、螺钉脱出、断裂等发生。疗效评价采用Kolmert评定标准:优A3型10例,C2型3例;良A3型2例,C2型1例,C3型5例:可C2型2例,C3型2例;差C3型1例。结论采用微刨固定系统LISS钢板治疗股骨远端粉碎骨折,是一种有效的内固定方法,具有操作简便、创伤小、疗效肯定等优点,为术后早期功能锻炼提供保证。 相似文献
59.
Mahmut Koç Ömer Yoldaş Yusuf Alper Kılıç Erdal Göçmen Tamer Ertan Hayrettin Dizen Mesut Tez 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2007,392(5):581-585
Background and aims The aim of this study is to evaluate the predictive accuracy of different scoring systems on surgery for perforated peptic
ulcer referred to an academic department of general surgery in a tertiary reference center.
Patients and methods Seventy-five consecutive patients (Male/female ratio = 64:11; mean age, 44 years; range, 16–85) with perforated peptic ulcer
disease were investigated. Disease severity scores and mortality predictions were calculated using the collected data during
admission. Discrimination and calibration characteristics of each system, namely, the acute physiology and chronic health
evaluation II and III, the simplified acute physiology score II, and the mortality probability models (MPM) II, were determined
by using the area under receiver operating characteristics curve and the Hosmer–Lemeshow goodness-of-fit test, respectively.
Results Among the 75 patients included, there were eight (10.6%) mortalities. All systems had a reliable power of discrimination and
calibration. Among the systems tested, MPM II was the best performing as far as discrimination and calibration characteristics
were considered. The parameters of MPM II system that were related to systemic perfusion of the patient were significantly
positive in patients who died compared to those who survived.
Conclusions MPM II that predicted mortality at admission is better than the other systems in predicting mortality. Results also indicate
the importance of maintenance of systemic perfusion of the patient at the early phases of peptic ulcer perforation. 相似文献
60.
This study uses the Taiwan Healthcare Indicator Series (THIS) system as an example to examine which determinants would improve
performance by sharing indicators from a management perspective. This study population included all 227 hospitals participating
in the THIS system in 2006. A structured questionnaire was sent to the director who was responsible for the THIS system via
electronic mail. A total of 111 responses were returned by February 10, 2006. Questions included current implementation and
impacts of the system. Hierarchical regression models were performed to identify which variables were significantly associated
with performance improvement, adjusted for hospital characteristics. Four variables significantly associated with implementing
the THIS system to improve performance were ‘senior management support,’ ‘benchmarking,’ ‘making departments improve the underperforming
indicators and report the improvement results in performance management meetings,’ and ‘integration with the National Health
Insurance payment regulations’. This study contributes substantially to the evidence base about what works to improve performance
by information sharing. Although information sharing is the basis of efforts to improve performance, senior management support
and how to effectively apply the information are the most important determinants of performance enhancement. 相似文献