全文获取类型
收费全文 | 48170篇 |
免费 | 2913篇 |
国内免费 | 1913篇 |
专业分类
耳鼻咽喉 | 170篇 |
儿科学 | 286篇 |
妇产科学 | 115篇 |
基础医学 | 3669篇 |
口腔科学 | 2049篇 |
临床医学 | 5229篇 |
内科学 | 1678篇 |
皮肤病学 | 49篇 |
神经病学 | 5077篇 |
特种医学 | 2522篇 |
外国民族医学 | 3篇 |
外科学 | 17111篇 |
综合类 | 8506篇 |
现状与发展 | 4篇 |
预防医学 | 1352篇 |
眼科学 | 208篇 |
药学 | 2737篇 |
64篇 | |
中国医学 | 1657篇 |
肿瘤学 | 510篇 |
出版年
2024年 | 129篇 |
2023年 | 765篇 |
2022年 | 1359篇 |
2021年 | 1968篇 |
2020年 | 1950篇 |
2019年 | 1514篇 |
2018年 | 1399篇 |
2017年 | 1577篇 |
2016年 | 1738篇 |
2015年 | 1661篇 |
2014年 | 3260篇 |
2013年 | 3466篇 |
2012年 | 2945篇 |
2011年 | 3177篇 |
2010年 | 2724篇 |
2009年 | 2533篇 |
2008年 | 2328篇 |
2007年 | 2489篇 |
2006年 | 2166篇 |
2005年 | 1979篇 |
2004年 | 1662篇 |
2003年 | 1403篇 |
2002年 | 1157篇 |
2001年 | 953篇 |
2000年 | 735篇 |
1999年 | 699篇 |
1998年 | 622篇 |
1997年 | 574篇 |
1996年 | 426篇 |
1995年 | 367篇 |
1994年 | 326篇 |
1993年 | 281篇 |
1992年 | 255篇 |
1991年 | 210篇 |
1990年 | 193篇 |
1989年 | 197篇 |
1988年 | 142篇 |
1987年 | 136篇 |
1986年 | 186篇 |
1985年 | 277篇 |
1984年 | 225篇 |
1983年 | 195篇 |
1982年 | 166篇 |
1981年 | 155篇 |
1980年 | 130篇 |
1979年 | 47篇 |
1978年 | 51篇 |
1977年 | 33篇 |
1976年 | 24篇 |
1975年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
We report the case of a thoracic epidural hematoma at the T7-T9 level which occurred after placement of spinal epidural catheter for continuous anaesthesia in acute pancreatitis. The male patient felt a sudden back pain after six days of successful analgesia and became paraplegic 24 hours afterwards. An emergency laminectomy and removal of the hematoma were performed; however, the patient recovered only incompletely.We discuss the clinical signs and symptoms of spinal epidural hematoma as well as its diagnostics and therapy. The controversial views from the literature concernings its etiology are critically reviewed. 相似文献
82.
R. P. Heaney T. M. Zizic I. Fogelman W. P. Olszynski P. Geusens C. Kasibhatla N. Alsayed G. Isaia M. W. Davie C. H. Chesnut III 《Osteoporosis international》2002,13(6):501-505
Risedronate treatment reduces the risk of vertebral fracture in women with existing vertebral fractures, but its efficacy
in prevention of the first vertebral fracture in women with osteoporosis but without vertebral fractures has not been determined.
We examined the risk of first vertebral fracture in postmenopausal women who were enrolled in four placebo-controlled clinical
trials of risedronate and who had low lumbar spine bone mineral density (BMD) (mean T-score =–3.3) and no vertebral fractures at baseline. Subjects received risedronate 5 mg (n= 328) or placebo (n= 312) daily for up to 3 years; all subjects were given calcium (1000 mg daily), as well as vitamin D supplementation (up
to 500 IU daily) if baseline serum 25-hydroxyvitamin D levels were low. The incidence of first vertebral fracture was 9.4%
in the women treated with placebo and 2.6% in those treated with risedronate 5 mg (risk reduction of 75%, 95% confidence interval
37% to 90%; P= 0.002). The number of patients who would need to be treated to prevent one new vertebral fracture is 15. When subjects were
stratified by age, similar significant reductions were observed in patients with a mean age of 64 years (risk reduction of
70%, 95% CI 8% to 90%; P= 0.030) and in those with a mean age of 76 years (risk reduction of 80%, 95% CI 7% to 96%; P= 0.024). Risedronate treatment therefore significantly reduces the risk of first vertebral fracture in postmenopausal women
with osteoporosis, with a similar magnitude of effect early and late after the menopause.
Received: 12 September 2001 / Accepted: 11 December 2001 相似文献
83.
S. T. F. M. Frequin F. J. M. Gabreë ls A. A. W. M. Gabreë ls-Festen E. M. G. Joosten 《Clinical neurology and neurosurgery》1991,93(4):323-326
A girl of 14 year is presented with a distal spinal muscular atrophy (SMA) with autosomal recessive inheritance. The technical findings are in agreement with the diagnosis. Light microscopical examination of sural nerve biopsy, including teased fiber studies and morphometry, showed no abnormalities. Electron microscopical investigation however demonstrated axonal pathology. The question arises if distal SMA is a distal axonopathy mainly of motor nerves, but to some extent also of sensory nerves. 相似文献
84.
目的探讨和分析应用锁骨钩钢板内固定配合康复治疗锁骨远端骨折的新方法。方法42例应用锁骨钩钢板配合术后早期康复治疗锁骨远端骨折的患者全部得到了随访,随访时间2~46个月(平均15.6个月),患者年龄36~57岁,平均45.6岁。术后2d患肩按照制定的康复训练方法进行功能训练,最终随访按Lazzcano评价标准〔1〕评价治疗结果。结果42例患者术后X线检查均达到满意复位与固定,局部Lazzcano功能评定关节功能恢复优良率97.6%。结论应用锁骨钩钢板治疗锁骨远端骨折手术操作简单,配合术后完善的康复治疗,可得到非常满意的结果。 相似文献
85.
[目的]揭示青少年胸椎特发性侧凸患者椎管内脊髓的偏移,明确其变化趋势,并探讨其可能的发生机制和临床意义。[方法]本研究包括39名以右胸弯为主弯的青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)患者。测量主胸弯节段内(T5-12)椎管内脊髓与凸凹侧椎弓根之间的距离,计算脊髓的偏移,揭示其变化趋势,并分析顶椎区脊髓偏移与主胸弯Cobb's角和顶椎相对偏移之间的相关性。[结果]在T5-12节段椎管内,脊髓与凸侧椎弓根之间的距离显著大于与凹侧椎弓根之间的距离(P〈0.05),即脊髓向凹侧椎弓根偏移,且以顶椎区最为显著,而逐渐向两侧端椎区递减。顶椎区脊髓偏移与主胸弯Cobb’s角和顶椎相对偏移存在显著的正相关(相关系数分别为0.631和0.546)。[结论]胸椎特发性脊柱侧凸患者存在侧凸节段椎管内脊髓偏移的现象,且以顶椎区最显著。研究结果提示脊髓偏移可能与脊椎偏移后凹侧脊神经的牵拉有关,而且凹侧置钉的风险高于凸侧。 相似文献
86.
神经干细胞静脉移植治疗脊髓损伤的实验研究 总被引:3,自引:0,他引:3
[目的]观察神经干细胞静脉移植对损伤大鼠脊髓功能的治疗作用。[方法]取孕14—16dSD胎鼠的脑室下区组织,体外培养后鉴定细胞。制作脊髓全切模型,伤后1周将Brdu标记好的神经干细胞通过尾静脉注射移植到大鼠体内,移植后及8周行皮层体感诱发电位(CSEP)检测和BBB功能评分,并留损伤脊髓处作病理切片及免疫组化染色。[结果](1)移植后8周BBB评分损伤组、移植组都有所恢复,但都未达到正常水平,移植组恢复较好;(2)模型制作后,CSEP波均消失,细胞移植后8周移植组的波形有不同程度的恢复,但潜伏期延长;(3)移植组大鼠脊髓损伤处存在大量Brdu染色阳性细胞,表明移植的细胞在体内可到达损伤脊髓处并能存活;脊髓损伤部位NF-200及GFAP染色阳性的细胞表明移植的细胞可以分化为具有神经元和胶质细胞特性的细胞。[结论]静脉移植的神经干细胞能到达损伤区代替受损的神经元及神经胶质细胞,使损伤的脊髓功能得到一定程度的恢复。 相似文献
87.
We followed all consecutive hip fracture patients admitted between 2004 and 2006, identified cases in which the intention was to treat non-operative and compared their functional outcome and mortality with a similar cohort treated surgically over the same period. We recorded length of hospital stay, place of discharge, pre and post-fracture mobility and residence, 30 days and 1 year mortality, re-admission due to same fracture and delayed surgery. The group treated surgically was recruited and matched for age, gender, pre and post-fracture mobility, mental confusion and independence. 25 patients were treated non-operative. 22 patients treated surgically over the same time period matched the patient characteristics of the non-operative arm. The mean hospital stay was 13 days in both groups. There were 4 extra-capsular fractures (3 displaced) and 21 intra-capsular fractures (5 displaced) in the non-operative arm and 11 extra-capsular fractures and 9 intra-capsular fractures in the surgically treated arm. 4 patients from the non-operative treatment group underwent late surgery because of persisting hip pain 20 days-2 months after the index event (2 cannulated screws, 1 hemiarthroplasty, 1 total hip arthroplasty). 11 patients in the surgical treatment arm underwent dynamic screw fixation, 1 had cannulated screw, 1 had total hip replacement and 7 had hemiarthroplasty. 14 of the non-operative treated patients were mobile independently or with aid before fracture but only 9 patients retained their pre-fracture mobility following treatment, compared to 16 patients pre-fracture and 11 patients post-fracture after surgery. 16 patients treated non-operative were living independently prior to injury but only 7 went back to their own residence. Of the operatively treated patients 14 patients were living independently and 10 patients went back to their previous residence. 1 month and 1 year mortality in the non-operative treated group was 4/21 and 7/21 respectively compared to 1/20 and 5/20 in the operative fixation group. There was no statistically significant difference in mobility, residence or mortality between the two groups (Fisher exact test, p > 0.05). Non-operative management after hip fracture is suitable for medically unfit patients and does not result in statistically significant difference in functional outcome or mortality compared to patients treated surgically. 相似文献
88.
89.
目的探讨经后路椎间盘镜手术治疗合并腰椎管狭窄症的椎间盘突出症的临床应用。方法采用后路椎间盘镜进行单侧开窗减压术。通过术前标记腰椎正侧位片定位,于定位棘突间隙后正中偏患侧作长约1.5 cm小切口,逐级扩张后置入工作通道管,钻除部分椎板,置入内窥镜,于电视监视器下显露椎板、增生内聚的关节突、肥厚的黄韧带及突出的椎间盘髓核组织,彻底解除其对硬脊膜、神经根的压迫。结果本组共治疗合并腰椎管狭窄症的腰椎间盘突出症23例,平均随访7个月,按Prolo标准评定,治愈20例,有效2例,无效1例。结论本术式在严格掌握适应证前提下对合并腰椎管狭窄症的腰椎间盘突出症患者效果明显。 相似文献
90.