收费全文 | 60244篇 |
免费 | 5048篇 |
国内免费 | 4281篇 |
耳鼻咽喉 | 382篇 |
儿科学 | 1680篇 |
妇产科学 | 744篇 |
基础医学 | 11546篇 |
口腔科学 | 1230篇 |
临床医学 | 5315篇 |
内科学 | 9075篇 |
皮肤病学 | 886篇 |
神经病学 | 3864篇 |
特种医学 | 1274篇 |
外国民族医学 | 29篇 |
外科学 | 3120篇 |
综合类 | 12804篇 |
现状与发展 | 22篇 |
一般理论 | 1篇 |
预防医学 | 3240篇 |
眼科学 | 1082篇 |
药学 | 4247篇 |
4篇 | |
中国医学 | 1371篇 |
肿瘤学 | 7657篇 |
2024年 | 116篇 |
2023年 | 608篇 |
2022年 | 1320篇 |
2021年 | 1828篇 |
2020年 | 1625篇 |
2019年 | 1558篇 |
2018年 | 1467篇 |
2017年 | 1644篇 |
2016年 | 1935篇 |
2015年 | 2002篇 |
2014年 | 2970篇 |
2013年 | 3988篇 |
2012年 | 3244篇 |
2011年 | 3997篇 |
2010年 | 3287篇 |
2009年 | 3325篇 |
2008年 | 3589篇 |
2007年 | 3888篇 |
2006年 | 3730篇 |
2005年 | 3514篇 |
2004年 | 3166篇 |
2003年 | 2755篇 |
2002年 | 2420篇 |
2001年 | 2206篇 |
2000年 | 1860篇 |
1999年 | 1551篇 |
1998年 | 1348篇 |
1997年 | 1117篇 |
1996年 | 803篇 |
1995年 | 687篇 |
1994年 | 517篇 |
1993年 | 344篇 |
1992年 | 259篇 |
1991年 | 206篇 |
1990年 | 175篇 |
1989年 | 113篇 |
1988年 | 82篇 |
1987年 | 60篇 |
1986年 | 47篇 |
1985年 | 68篇 |
1984年 | 39篇 |
1983年 | 19篇 |
1982年 | 31篇 |
1981年 | 22篇 |
1980年 | 13篇 |
1979年 | 11篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 2篇 |
Objective
To assay peripheral inter-ictal cytokine serum levels and possible relations with non-invasive vagus nerve stimulation (nVNS) responsiveness in migraineurs.Methods
This double-blinded, sham-controlled study enrolled 48 subjects and measured headache severity, frequency [headache days/month, number of total and mild/moderate/severe classified attacks/month], functional state [sleep, mood, body weight, migraine-associated disability] and serum levels of inflammatory markers [inter-ictal] using enzyme-linked immunoassays at baseline and after 2 months of adjunctive nVNS compared to sham stimulation and suitably matched controls.Results
No significant differences were observed at baseline and after 2 months for headache severity, total attacks/month, headache days/month and functional outcome [sleep, mood, disability] between verum and sham nVNS. However, the number of severe attacks/month significantly decreased in the verum nVNS group and circulating pro-inflammatory IL-1β was elevated significantly in the sham group compared to nVNS. Levels of anti-inflammatory IL-10 were significantly higher at baseline in both groups compared to healthy controls, but not at 2 months follow-up [p?<?0.05]. Concentrations of high-mobility group box-1 (HMGB-1), IL-6, tumor-necrosis factor-α (TNF-α), leptin, adiponectin, ghrelin remained unchanged [p?>?0.05]. No severe device-/stimulation-related adverse events occurred.Conclusion
2 months of adjunctive cervical nVNS significantly declined the number of severe attacks/month. Pro-inflammatory IL-1β plasma levels [inter-ictal] were higher in sham-treated migraine patients compared to verum nVNS. However, pro- [IL-6, HMGB-1, TNF-α, leptin] and anti-inflammatory [IL-10, adiponectin, ghrelin] mediators did not differ statistically. Profiling of neuroinflammatory circuits in migraine to predict nVNS responsiveness remains an experimental approach, which may be biased by pre-analytic variables warranting large-scale biobank-based systematic investigations [omics]. 相似文献Methods and Results: This case-control association study contained 1673 samples, including 869 ophthalmic patients and 804 controls. Twelve tag SNPs have been selected from the MYP10 and MYP15 loci and genotyped by SNaPshot method. Among 12 SNPs, rs4840437 and rs6989782 in TNKS gene were found significant association with HM. Carriers of rs4840437G allele and rs4840437GG genotype created a low risk of high myopia (P = .036, OR = 0.81, 95%CI = 0.71–0.93; P = .016, OR = 0.73, 95%CI = 0.56–0.96; respectively). Carriers of rs6989782T allele and rs6989782TT+CT genotype also had a decreased risk of high myopia (P = .048, OR = 0.82, 95%CI = 0.71–0.94; P = .006, OR = 0.74, 95%CI = 0.59–0.92; respectively). Other 10 SNPs displaced nonsignificant association with HM. Additionally, the risk haplotype AC and the protective haplotype GT, generated by two SNPs in TNKS, were considerably more likely to be association with HM (for AC, P = .002 and OR = 1.26; for GT, P = .027 and OR = 0.84).
Conclusions: Our results demonstrated that some heritable variants in the TNKS gene are associated with HM in the Han population. The possible functions of TNKS in the development and pathogenesis of hereditary high myopia still require further researches to identify. 相似文献