多媒体技术在磁共振教学中的应用

利用VB编程技巧、flash动画制作技术、powerpoint技术和视频录象,以教学课件的形式展示磁共振成像的物理机理。     

《医学术语双语学习软件》的设计与实现

以双语教学的要求及现状为基础,提出使用软件辅助学习医学英语术语的方法,介绍了软件的一些基本功能及软件设计、素材处理要求和开发的过程。     

The Function Of A Vitamin B6 Coenzyme In The Activation And Nuclear Binding Of Steroid Receptors

Pyridoxal 5'-phosphate reacts with activated cytosolic steroid-receptor complex, presumably by Schiff-base linkage, to inhibit its binding to DNA or cell nuclei. Vitamin B ₆ deficiency produces liver cytosol that has more activated glucocorticoid-receptor complex that can bind to DNA, and a more rapid rate of nuclear binding than controls.     

PHOSPHORYLASE RESPONSE TO VITAMIN B6 FEEDING

Weanling rats fed pyridoxine at levels equal to and ten times those recommended by the National Research Council accumulate extra muscle phosphorylase for at least six weeks, with reference to both age and muscle weight, but in proportion to the vitamin B₆ retained.     

METOCLOPRAMIDE AS A DOPAMINE ANTAGONIST IN THE HEART AND GUT OF THE MOLLUSC TAPES WATLINGI

SUMMARY 1. Metoclopramide is a potent antagonist of the inhibitory response to dopamine in two isolated tissues, the electrically stimulated intestine and the spontaneous beating heart, from the mollusc Tapes watlingi.
2. Blockade by metoclopramide of dopamine receptors in the central nervous system of man may account for the relapse of patients with Parkinson's disease which occurs when metoclopramide is given during successful therapy with levodopa.     

Effects of tetrahydroisoquinolines on dopa decarboxylase and pyridoxal kinase

The mechanism of the nullification of the therapeutic effects of levodopa by pyridoxine in parkinsonian patients is not known and is still a subject of much speculation. Among other suggestions, it has been proposed that pyridoxine and levodopa may form tetrahydroisoquinoline derivatives in vivo, which may in turn inhibit dopa decarboxylase or act as a false transmitter. This possibility was tested by synthesizing six tetrahydroisoquinoline derivatives and by studying their effects on dopa decarboxylase in brain homogenates. These compounds in concentrations of 50 mM did not inhibit dopa decarboxylase or pyridoxal kinase, which synthesizes pyridoxal phosphate.     

利用VB6.0处理GPS数据

本文分析了GPS定位数据的数据格式及信息组成,阐述了利用VB6．0进行串行数据通讯的特点及实际应用,并给出了处理GPS定位数据的有关的源程序代码。     

Interbronchoscopist variability in endobronchial path selection: a simulation study

BACKGROUND: Endobronchial path selection is important for the bronchoscopic diagnosis of focal lung lesions. Path selection typically involves mentally reconstructing a three-dimensional path by interpreting a stack of two-dimensional (2D) axial plane CT scan sections. The hypotheses of our study about path selection were as follows: (1) bronchoscopists are inaccurate and overly confident when making endobronchial path selections based on 2D CT scan analysis; and (2) path selection accuracy and confidence improve and become better aligned when bronchoscopists employ path-planning methods based on virtual bronchoscopy (VB). METHODS: Studies of endobronchial path selection comparing three path-planning methods (ie, the standard 2D CT scan analysis and two new VB-based techniques) were performed. The task was to navigate to discrete lesions located between the third-order and fifth-order bronchi of the right upper and middle lobes. Outcome measures were the cumulative accuracy of making four sequential path selection decisions and self-reported confidence (1, least confident; 5, most confident). Both experienced and inexperienced bronchoscopists participated in the studies. RESULTS: In the first study involving a static paper-based tool, the mean (+/- SD) cumulative accuracy was 14 +/- 3% using 2D CT scan analysis (confidence, 3.4 +/- 1.3) and 49 +/- 15% using a VB-based technique (confidence, 4.2 +/- 1.1; p = 0.0001 across all comparisons). For a second study using an interactive computer-based tool, the mean accuracy was 40 +/- 28% using 2D CT scan analysis (confidence, 3.0 +/- 0.3) and 96 +/- 3% using a dynamic VB-based technique (confidence, 4.6 +/- 0.2). Regardless of the experience level of the bronchoscopist, use of the standard 2D CT scan analysis resulted in poor path selection accuracy and misaligned confidence. Use of the VB-based techniques resulted in considerably higher accuracy and better aligned decision confidence. CONCLUSIONS: Endobronchial path selection is a source of error in the bronchoscopy workflow. The use of VB-based path-planning techniques significantly improves path selection accuracy over use of the standard 2D CT scan section analysis in this simulation format.     

4～5岁儿童核黄素营养状况评价指标探讨

以40名4～5岁全托健康儿童为受试对象,在数次尿样测定中发现1、4及24h尿肌酐的平均排泄量各自不等,且变异较大;还发现无论核黄素(VB_2)摄入充足与否,空腹尿、任意尿中VB_2/肌酐与24h尿中VB_2量及其VB_2/肌酐之相关结果也不一致,在同一个体,各不同尿样的VB_2/肌酐也不稳定。提示以任意一次尿样VB_2/肌酐来评价机体VB_2营养状况都必须十分慎重。 在VB_2摄入充足或不足时,儿童以2.5mg进行VB_2 4h负荷试验的敏感性,均高于以5.0mg为负荷量的结果,且前者与24h尿VB_2排泄量呈现相关。故认为儿童VB_2 4h负荷试验,以2.5mg为负荷量较稳妥。     

Diagnosis of pyridoxine-dependent epilepsy in an adult presenting with recurrent status epilepticus

Pyridoxine-dependent epilepsy (PDE) is a genetic metabolic disease caused by inborn errors affecting vitamin B6 metabolism, which typically presents with neonatal seizures resistant to antiepileptic drugs (AEDs). Treatment with pyridoxine terminates seizures and prevents neurological decline. We describe a case in which the diagnosis was established at the age of 22 years. Birth and development were normal, but there was a history of three isolated tonic-clonic seizures during childhood and adolescence. At the age of 18 years, she developed frequent focal motor seizures, many evolving into tonic-clonic seizures. Electroencephalography identified a focus in the posterior right hemisphere, but magnetic resonance imaging of the brain was normal. Over the next 3 years, she was hospitalized with uncontrolled seizures on six occasions and spent a total of 121 days in intensive care. The seizures proved resistant to 12 different AEDs. Exome sequencing revealed two pathogenic mutations in ALDH7A1. Since starting on pyridoxine 50 mg once daily, she has been seizure-free, all AEDs have been withdrawn, and cognition has improved to premorbid levels. This case illustrates the importance of considering PDE in drug-resistant epilepsy in adults.