高效液相色谱法测定盐酸异丙嗪片的含量

目的 :建立测定盐酸异丙嗪片中盐酸异丙嗪含量的方法。方法 :采用高效液相色谱法。结果 :盐酸异丙嗪在 5～ 10 0 μg/ml浓度范围内线性良好 ,r =0 9997,平均回收率为 99 9% ,RSD为 0 95%。 结论 :此法方法简便 ,结果准确 ,可用于盐酸丙嗪片生产和储藏过程中的质量控制     

Ketamine sequelae

The ability of a number of drugs to abolish the emergence delirium and unpleasant dreams which follow anaesthesia induced with 2 mg/kg ketamine was studied. These included three benzodiazepines, droperidol and 'neurolept' combinations and four commonly-used premedicants. When given intravenously 10 min before induction of anaesthesia flunitrazepam and lorazepam gave best results. In a subsequent study, these two benzodiazepines and diazepam were given intravenously 30-40 min before induction of anaesthesia. There was no doubt that 4 mg lorazepam gave the greatest protection and is worthy of further study in this respect.     

盐酸异丙嗪对芬太尼诱发咳嗽的影响

目的 观察静脉注射小剂量抗组胺药盐酸异丙嗪对芬太尼诱发咳嗽的影响.方法 选200例拟行全身麻醉择期手术患者,术前分为4组:对照组和试验1、2、3组,麻醉诱导前各组分别给予0.1 mL/kg的4种药液:0.9％盐水,0.5、1.0、1.5mg/mL异丙嗪,所有患者麻醉诱导注射芬太尼3μg/kg,记录注射芬太尼2 min内患者咳嗽发生情况,包括咳嗽发生次数、强度、时间以及收缩压、舒张压、心率情况.结果 试验1、2、3组咳嗽发生率为16％、12％、10％,与对照组(32％)相比明显下降(P＜0.05);试验1、2、3组轻度咳嗽发生率与对照组相比明显下降(P＜0.05);各组中度和重度咳嗽发生率比较差异无统计学意义(P＞0.05);发生咳嗽的平均时间4组比较差异无统计学意义(P＞0.05).T4时点对照组、试验2组、试验3组的舒张压升高较试验1组明显,差异有统计学意义(P＜0.05),试验3组心率增快高于对照组和试验1组、试验2组,差异有统计学意义(P＜0.05).结论 预注盐酸异丙嗪可降低芬太尼诱发咳嗽的发生率.     

Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: A motion sickness medication

The current method of choice for astronauts to treat space motion sickness is an intra-muscular injection of promethazine hydrochloride (PMZ HCl) which is invasive and causes considerable local irritation and discomfort at the site of injection. Intra-nasal delivery is considered a feasible alternative route for administration of medications to treat space motion sickness. The purpose of this research is to develop a PMZ HCl formulation that can be administered intra-nasally without irritation (i.e. leukocyte infiltration) in the nasal epithelium when dosed at PMZ HCl concentrations greater than the cytotoxic limit. The biocompatibility of PMZ HCl was tested in vitro and was shown to be cytotoxic at concentrations greater than 10^?5 molar regardless of pH. A controlled-release microencapsulated dosage formulation was developed using spinning disk atomization and release rates for the PMZ HCl microcapsules were determined in phosphate buffered saline. An animal study was conducted to determine the irritation response of rat nasal mucosa when dosed with encapsulated and non-encapsulated PMZ HCl.     

Movement Disorders From the Use of Metoclopramide and Other Antiemetics in the Treatment of Migraine

Nausea and vomiting are a frequent accompaniment of migraine and anti‐nausea medications are frequently used in its management. The majority of anti‐nausea medications that are used in migraine are dopamine receptor blocking agents and therefore have the potential to cause drug‐induced movement disorders. This article explores the risk of such drug‐induced movement disorders in migraineurs who were treated with these medications.     

盐酸异丙嗪注射液的流动注射分析测定

采用流动注射分析仪，根据盐酸异丙嗪可与钯离子发生配位显色反应的原理，测定盐酸异丙嗪注射液的含量。线性范围为０～１３０μｇ／ｍｌ，变异系数小于１．０％。     

小儿清肺止咳糖浆中盐酸异丙嗪稳定性研究

小儿清肺止咳糖浆中盐酸异丙嗪稳定性研究常忆凌,刘尚保（武汉市二医院,武汉４３００１４）刘本（湖北中医学院,武汉４３００６１）小儿清肺止咳糖浆由桔梗、黄芩、川贝、杏仁等六味中药和盐酸异丙嗪组成。本文用三波长分光光度法对糖浆中的盐酸异丙嗪进行了测定,研究...     

复方利血平片中盐酸异丙嗪的含量测定及含量均匀度考察

目的建立测定复方利血平片中盐酸异丙嗪含量的高效液相色谱法。方法采用AgilentTCC18柱（250mm×4．6mm,5μm）,以乙腈-0．3％十二烷基硫酸钠溶液-磷酸（60：40：0．02．用三乙胺调pH至3．3）为流动相,流速为1．0mL／min,检测波长为250nm。结果盐酸异丙嗪进样量在0．504～1．176μg范围内与峰面积线性关系良好,r=0．9999（n=5）,平均回收率为98．71％,RSD=0．80％（n=9）。结论该法适用于复方利血平片中盐酸异丙嗪的含量测定。     

异丙嗪对异氟烷小鼠镇痛、催眠、遗忘作用和治疗指数的影响

目的观察异丙嗪对异氟烷镇痛、催眠、遗忘作用和治疗指数的影响。方法用热板法和扭体法观察异丙嗪对异氟烷镇痛作用的影响,翻正反射法观察异丙嗪对异氟烷小鼠睡眠时间的影响,Morris水迷宫法观察异丙嗪对异氟烷小鼠遗忘作用的影响,并用序贯法观察异丙嗪对异氟烷小鼠催眠ED50、LD50的影响。结果在热板法和扭体法实验中,异丙嗪增强了异氟烷的镇痛作用(P<0.05或P<0.01);在翻正反射实验中,异丙嗪可延长异氟烷小鼠的睡眠时间(P<0.01);在水迷宫实验中,异丙嗪组和异氟烷组的平均逃避潜伏期均少于两药合用组(P<0.05或P<0.01),第3象限停留时间均多于两药合用组(P<0.01或P<0.05),异氟烷组原平台穿越次数多于合用组(P<0.05);异丙嗪可降低异氟烷小鼠的催眠ED50(P<0.01),而对其LD50无影响(P>0.05)。结论异丙嗪可以增强异氟烷的镇痛、催眠和遗忘作用,并可以提高异氟烷的治疗指数。     

糖衣对盐酸异丙嗪片含量测定的影响

目的：研究糖衣对盐酸异丙嗪片含量测定的影响。方法：采用紫外分光光度法,并进行配对设计的t检验。结果：糖衣溶液在200~400 nm范围内无吸收,平均回收率为99.69%（n=5）,RSD为0.86%,两种方法测得结果差别无显著性意义（P〉0.05）（n=4）。结论：糖衣对盐酸异丙嗪片的含量测定无干扰,可不剥糖衣进行该片的含量测定。