咽炎康颗粒制备工艺研究

为了优化咽炎康颗粒的制备工艺,采用正变试验法,以熊果酸、多糖等为指标,得出最佳的浸提工艺参数,同时考察了最佳的喷雾干燥及制粒条件．进而得出合理的颗粒制备工艺。     

青光眼手术疗法的进展

综述了近年来国内对治疗青光眼手术方法的改进,主要包括小梁移植术、房水引流器植入术、无结膜切口的小梁切除术、外路小梁切开术、新生血管性青光眼冷冻联合手术治疗、滤过手术联合药物防止瘢痕形成等。对这些手术优缺点和临床应用进行了比较     

Interaction of light with the organ of Corti

Summary A cochlear postmortem preparation has been developed which allows for hydromechanical studies of the transilluminated organ of Corti. It was found that cochlear hair cells act as optical waveguides. This property of hair cells is important for optical cochlear investigations. It may be used in the study of the motion of single hair cells.     

The atrioventricular junction in the univentricular heart: A two-dimensional echocardiographic analysis

Summary The atrioventricular junction of 40 patients with univentricular heart was evaluated by two-dimensional echocardiography. The apical 4 chamber view optimally imaged the atrioventricular junction, and allowed determination of the type of atrioventricular connection: double inlet, common atrioventricular orifice, and absent right or left atrioventricular connection. When double inlet to 1 ventricle was demonstrated, the 4 chamber view allowed immediate comparison of the form and function of the right and left atrioventricular valves. Because anomalies of the atrioventricular valves frequently complicate the univentricular heart, two-dimensional echocardiographic assessment is a most important adjunct to the preoperative investigation of these patients.     

Sterilization in Bangladesh: mortality, morbidity, and risk factors

Although surgical sterilization in Bangladesh is common and has been designated as the primary means of helping the country slow its population growth, no reliable information exists regarding the procedure's safety. To define the types and rates of medical complications associated with sterilization, we followed 5042 women and 264 men undergoing sterilization. The problems that increased most markedly after the procedure compared with before included painful urination, shaking chills, fever for at least 2 days, and frequent urination. Most of the postoperative problems could be predicted by the presence of the same problem before the operation. Factor analysis of complaints in those persons who did not have a specific preoperative complaint showed that complaints clustered into three groups: urinary tract symptoms (urinary urgency and frequency), skin problems (bleeding from the incision, sore with pus, and stitches or skin breaking open), and general complaints (weakness and dizziness). The patient's sex, the sponsor and patient load of the sterilization center, and the dose of sedatives administered to women were significantly associated with specific postoperative complaints. Five women died during the study, resulting in a death-to-case rate of 9.9/10,000 procedures tubectomies; four deaths were due to respiratory arrest caused by oversedation.     

盐酸氨溴索缓释胶囊的药代动力学和生物等效性研究

目的：研究单剂量口服（ｐｏ）自制盐酸氨溴索（Ａｍ ｂ）缓释胶囊的药代动力学和生物利用度。方法：采用ＲＰ－ＨＰＬＣ法测定８名健康志愿者单剂量ｐｏ ７５ ｍ ｇ 自制（Ａ）和进口（Ｂ）Ａｍ ｂ 缓释胶囊后的血药浓度,计算药代动力学参数与相对生物利用度,并以配对ｔ检验进行统计分析。结果：单剂量ｐｏ Ａ 与Ｂ的ｔｍ ａｘ ,ｔ１／２,ｃｍ ａｘ ,ＡＵＣ０～ｔ分别为（５．００±１．０７）,（４．６２±１．１９） ｈ;（４．０６±０．６１）,（４．２１±０．９３） ｈ;（１５３．６２±２９．２０）,（１４８．３６±１７．９１） ｎｇ／ｍ ｌ;（１ ４１０．３６±３３６．０６）,（１ ２９４．３６±２２５．０７）ｈ·ｎｇ／ｍ ｌ。结论：两种制剂的体内吸收和峰浓度以及经对数转换都无显著性差异（Ｐ＜ ０．０５）,具有生物等效性,自制胶囊的相对生物利用度为（１０８．２７±１５．５７）％ 。     

HPLC法测定三七及其制剂中三七素

三七为五加科植物三七P anax notog inseng(Burk.)F.H.Chen的干燥根,其中所含三七素(dencich ine,β-草酰基-L-,αβ-二氨基丙酸)具有止血作用[1,2],因此三七在祖国传统医药中广泛用于跌打损伤的治疗。研究进一步证明三七素具有止血、增加血小板数的药理活性[3]。目前,三七素的测定主要采用的是氨基酸自动分析仪[4,5],该法具有分析结果准确的优点,但仪器价格昂贵,且不能应用于其他成分的分析。也有将三七素进行荧光衍生化后,采用薄层扫描的方法测定[6],但衍生化产物不稳定,扫描定量中引起误差的因素较多,准确度不高。本实验采用离子对反…     

2019版《中国消化内镜诊疗相关肠道准备指南》解读

随着内镜技术的发展和普及,肠镜检查的重要性进一步突显,肠道准备作为肠镜检查的前提条件显得尤为重要。为进一步改进我国内镜检查前肠道准备的方法,提高内镜检查的质量,结合我国实际情况,中国医师协会内镜医师分会消化内镜专业委员会联合中国抗癌协会肿瘤内镜学专业委员会对旧版指南进行了更新。本文对2019版《中国消化内镜诊疗相关肠道准备指南》的更新内容进行解读,以期更好地加深内镜医护人员对《新指南》的认知和理解,指导患者进行肠道准备,从而最大程度提高肠镜诊疗效果,更大程度的使患者获益。     

不同抗凝剂种类、操作和保存方法对血浆微粒检测影响

目的探讨不同抗凝剂种类、标本处理方式、保存温度及时间对血浆微粒(MPs)检测效果的影响。方法采集2013年8月-2014年5月在苏州大学附属第二医院住院治疗的40例系统性红斑狼疮患者、41例类风湿性关节炎患者和52名健康对照者血浆标本;采用流式细胞术(FCM)计数不同抗凝剂[枸橼酸盐、乙二胺四乙酸二钾(EDTA-K₂)、肝素]、标本处理方式[洗涤贫血小板血浆(PPP)和直接PPP]、保存温度(-4、-20、-80 ℃)及时间(1、3、7、10、14 d)血浆中MPs的含量。结果采用枸橼酸盐、EDTA-K₂、肝素抗凝剂和无抗凝剂血浆中MPs含量分别为(1 527.0±620.4)、(981.4±247.9)、(877.7±176.2)和(480.8±112.2)μL, 差异有统计学意义(F=9.11, P<0.01);系统性红斑狼疮患者、类风湿性关节炎患者和健康对照者直接PPP MPs含量分别为(1 972.4±2 850.7)、(3 347.8±3431.5)和(2 157.7±1 901.1)μL, 均高于洗涤PPP的(1 406.4±2 205.7)、(2 375.6±2 500.2)和(1 502.8±1 337.1)μL(均P<0.01);与新鲜血浆标本MPs含量比较, -4 ℃、-20 ℃下血浆标本保存1、3、7、10 d 和-80 ℃下血浆标本保存3、7、10 d MPs含量均下降, 差异均有统计学意义(P<0.05);而在3个温度下保存14 d MPs含量开始升高, 与新鲜血浆标本MPs含量比较, 差异均无统计学意义(P>0.05);分别对3个温度下保存1、3、7、10、14 d血浆标本MPs含量比较, 差异均无统计学意义(P>0.05)。结论检测血浆MPs含量时宜选用新鲜EDTA-K₂抗凝标本且无需多次离心洗涤, 短期内标本保存在-4 ℃、-20 ℃、-80 ℃下均可。     

拉莫三嗪与丙戊酸镁缓释片治疗双相障碍躁狂发作的疗效比较

目的：观察拉莫三嗪与丙戊酸镁缓释片治疗双相障碍躁狂发作的疗效和安全性。方法：符合CCMD- 3的74例双相障碍躁狂病人分为治疗组和对照纽各37例,治疗组给予拉莫三嗪片25 mg·d~(-1),逐渐加至100～200 mg·d~(-1),分2次,po,8 wk；对照组给予丙戊酸镁缓释片0．25 g·d~(-1),逐渐加至0．75～1．0 g·d~(-1),分2次,po,8 wk。采用躁狂量表(BRMS)、临床疗效总量表(CGI)评定临床疗效,不良反应量表(TESS)评定不良反应。结果：治疗组总有效率为75%,对照组为80%,2组疗效差异无显著意义(P＞0．05)。治疗组常见不良反应是头痛、乏力,对照组常见不良反应是恶心、困倦,2组不良反应发生率无显著差异(P＞0．05)。结论：拉莫三嗪、丙戊酸镁缓释片治疗双相障碍躁狂发作均有效、安全、耐受性好。