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91.
Robbert-Jan Roozeman Lasse Murtomäki Kyösti Kontturi 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》2005,575(1):9-17
A recently introduced setup to measure the dynamic interfacial tension of expanding drops was used to compare the adsorption behaviour of a series of lipids at the electrified water∣dichloroethane interface. Phospholipids with saturated carbon chains of different length (DMPC, DPPC, DSPC, DAPC, DBPC), an unsaturated phospholipid (DOPC) and an ethanolamine (DSPE) were compared. It was found that the adsorption decreases with increasing chain length. Also, the increase of the flow rate reduces the degree of adsorption effectively. On the timescale of the experiments, the DSPE, DAPC and DBPC adsorption showed no potential dependence, whereas the adsorption of DOPC was stronger than that of the saturated lipids. Adsorption was modelled using the Langmuir adsorption isotherm; the potential dependence of adsorption is discussed. 相似文献
92.
M L Cibull M E Thompson L Smith C D Jennings M A Doukas E J Pavlik D E Powell 《American journal of hematology》1987,24(3):293-299
The emergence of a near-haploid clone of cells in blast phase chronic myelogenous leukemia is an unusual event. We report such a case and review eight other cases described in the English literature. The significance of the substantial loss of genetic material is discussed as is the phenotypic and genotypic heterogeneity observed in this group of patients. 相似文献
93.
Lijun Di Jun Ren Ying Yan 《中德临床肿瘤学杂志》2007,6(4):393-395
Objective: To evaluate the effect and safety of clinical use of zoledronic acid in the treatment of malignant hypercalcemia. Methods: A multi-center, open phase II clinical trial was conducted in 15 cases with malignant hypercalcemia who received zoledronic acid intravenously for 15 min. The level of blood calcium and side effects were recorded regularly within 28 days after injection. Results: One case was dropped out due to bad compliance. The complete response rate (the corrected serum calcium was reduced to normal level) was 100.00% (14/14). The medium time of complete response rate was 5.07 days. The medium maintain time was 22.30 days. Slight, or moderate fever was observed. Conclusion: Zoledronic acid can effectively reduce the malignant hypercalcemia. The use of zoledronic acid appears to be safety and convenient. 相似文献
94.
Stephan E. Maier Harvey E. Cline Ferenc A. Jolesz 《Magnetic resonance in medicine》1995,34(5):706-712
Three dimensional (3D) phase contrast angiograms contain velocity data, which is discarded after the reconstruction of the projections. In extension to earlier work on velocity quantification with ungated 2D phase data, this paper shows that a useful estimate of the average velocity and flow rate can be extracted from ungated 3D phase contrast angiograms. Simulations and experiments in a phantom and in vivo were performed. For pulsatile flow and strong spin saturation, an over-estimation of the flow rate at the net in-flow end of the imaging volume and underestimation at the net out-flow end was observed. Imaging at lower RF tip angles yielded flow rates close to the correct value within the entire imaging volume. In contrast to ungated 2D experiments, the flow rates determined by repeated 3D experiments showed no variation. 相似文献
95.
枢复宁在肺癌患者体内的药物动力学和生物利用度 总被引:3,自引:1,他引:2
9名接受顺铂化疗的原发性肺癌患者单次口服和静脉注射枢复宁8mg后,用反相高效液相色谱法测定血浆药物浓度。经用PKBP-N1程序在计算机上拟合计算表明,枢复宁在人体内表现为二房室模型。口服后主要药动学参数:T1/2Ka=0.41±0.30h,T1/2α=0.9±0.43h,T1/2β=3.3±1.2h,Cmax=28.6±9.5ng/ml,Tmax=1.7±0.9h,AUC=158±73ng·h/ml,绝对生物利用度为55%。 相似文献
96.
Zakiya Al-Lamki Eileen Thomas Nagwa El-Banna Norman Jaffe 《Pediatric blood & cancer》1995,24(2):137-140
We report an unusual case of anaphylaxis and hepatitic dysfunction in a child with the administration of the twenty-third course of high-dose methotrexate. The latter had been used as an adjuvant to prevent pulmonary metastases and the prior 22 courses had been well tolerated. An attempt to reinstate methotrexate after the twenty-third course was again followed by a similar reaction. © 1995 Wiley-Liss, Inc. 相似文献
97.
毛细管气相色谱法测定人体血液中的游离脂肪酸和总脂肪酸 总被引:1,自引:0,他引:1
张伟利 《中华临床营养杂志》1997,(1)
采用石英毛细管气相色谱法测量人体血液中的游离脂肪酸(FFA)和总脂肪酸(TFA),方法灵敏,可分离血浆中近20种脂肪酸,其中油酸(C18:1)、软脂酸(C16:0),亚油酸(C18:2)、硬脂酸(C18:0)和软脂油酸(C16:1)约占血浆中FFA总量的90%。本方法所需血量少,尤其对采血较困难的婴儿进行脂肪营养研究适用。 相似文献
98.
铜绿假单胞菌全细胞脂肪酸气相色谱分析及应用 总被引:5,自引:0,他引:5
本研究用计算机控制,可程序升温的毛细管柱气相色谱(GC)仪分析48株铜绿假单胞菌标准株和临床株、部分常见假单胞菌、肠杆菌的细胞脂肪酸。结果表明:月桂烯酸(C12:1),月桂酸(C12:0)、十三碳烯酸(C13:1)、十三碳酸(C13:0)、肉豆劳动脑酸(C14:1)、十七碳稀酸(C17:1)、十七碳酸(C17:0)、硬脂酸(C18:0)和花生四烯酸(C20:4)是铜绿包菌有鉴别意义的脂肪酸,组成与 相似文献
99.
Hermann Müller Stina Olsson Kari-Johan Söderholm 《European journal of oral sciences》1997,105(4):362-365
Experimental composites using either bisGMA/TEGDMA or UEDMA/ TEGDMA matrices, quartz or barium glass fillers, and 2 different filler silanization methods were evaluated regarding monomer leachability in distilled water. The leached amount was detected and quantified using gas chromatography. The results showed that twice as much TEGDMA is leached from a bisGMA/TEGDMA based composite than from an UEDMA/ TEGDMA based composite, when both contain 50 wt% TEGDMA. The hypothesis suggested that the higher degree of cure of UEDMA/TEGDMA based composites would be reflected in a lower monomer leaching value, and this hypothesis was supported by the findings. Whether such a correlation exists within groups of UEDMA/TEGDMA based matrices having different degrees of cure was not determined and needs to be investigated in future studies. Variables such as filler composition and silane treatment did not affect the leaching values of TEGDMA in water. That finding suggests that future studies should target differences in matrices, and that the need for considering effects of filler composition and silane treatment methods should not receive the same priority. 相似文献
100.
环丙沙星滴眼剂在家兔眼内组织分布及其药物动力学 总被引:2,自引:1,他引:1
环丙沙星(ciprofloxacin,CPFX)滴眼液点入兔眼后,用HPLC法测定眼内各组织中药物浓度。结果在角膜、房水、虹膜-睫状体、晶体、玻璃体内峰浓度值分别为19.43μg/g,1.58μg/ml,16.68μg/g,1.42μg/g和0.96μg/ml;其半衰期分别为0.76,0.69,0.92,0.61和1.40h。结果表明CPFX能在眼内达到较高的抗菌浓度。 相似文献