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61.
刘艳秋 《中国新药与临床杂志》2012,(3):168-170
目的评价3种常用长效钙通道阻滞药治疗轻、中度原发性高血压的疗效和成本-效果。方法门诊轻、中度原发性高血压患者180例随机分为3组,每组60例,分别口服硝苯地平30 mg、非洛地平5 mg和氨氯地平5 mg,每日1次,疗程8 wk,观察3组疗效并进行成本-效果分析。结果硝苯地平、非洛地平和氨氯地平有效率分别为90%、93%和95%,3组间无显著差异(P>0.05);成本-效果比分别为11.54、10.35和11.28,以非洛地平组为参照,硝苯地平和氨氯地平的增量成本-增量效果比分别为22.06和62.59。结论非洛地平治疗轻、中度原发性高血压成本-效果优于硝苯地平和氨氯地平。 相似文献
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Jessica C. Graham Nathan Wilt Caren Villano Jackie Bader Lindsay Krawiec 《Cutaneous and ocular toxicology》2018,37(4):380-390
Introduction: Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on eye and skin can now be assessed using validated in vitro methods.Objectives: Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular and dermal irritation/corrosion potential of PCs to inform worker safety within the pharmaceutical space. Bristol–Myers Squibb (BMS) and the Institute for In Vitro Sciences (IIVS) have therefore conceptualized and internally qualified a tiered in vitro testing strategy to inform occupational hazards regarding eye and skin irritation and corrosivity of PCs. For the small scale pre-qualification phase, we paired historical in vivo and newly generated in vitro data for 15 PCs to determine the predictive capacity of in vitro assays already validated for the eye and skin irritation/corrosion endpoints and accepted for certain regulatory submissions. During the post-qualification phase, a group of 24 PCs were subjected exclusively to the developed tiered testing strategy, which is based on three Organisation for Economic Co-operation and Development (OECD) in vitro methods.Materials and methods: The qualified in vitro testing strategy utilizes the Corrositex® assay for the corrosivity (OECD TG 435), the Bovine Corneal Opacity and Permeability (BCOP) assay for ocular irritation (OECD TG 437), and the EpiDerm? tissue model-based Skin Irritation Test (SIT) for dermal irritation (OECD TG 439). In the first step, the pH of each PC was determined. For compounds with pH extremes ≥11 or ≤2, the Corrositex® assay was generally conducted first. For compound(s) that were incompatible with or were negative in the Corrositex® assay or had pH values between 2 and 11, the BCOP assay and SIT were performed first.Results: The results of the tiered testing strategy’s qualification phase demonstrated that the BCOP assay is sensitive enough to identify a wide range of eye irritation/corrosion potentials and its over-prediction rate was considered acceptable to inform occupational hazards and ensure the proper handling practices of PCs. The SIT correctly predicted the skin irritation potential of 14 out of the 15 PCs included in the qualification phase, only over-predicting one PC. In the post-qualification phase, four PCs out of four tested were predicted corrosive by the Corrositex® assay and thus no further testing was needed or conducted. The rest of the PCs were evaluated in the BCOP assay (both neat and as a 20% dilution), with the higher response being used for hazard classification. Four PCs were determined to be severe eye irritants, 1 a moderate irritant, 8 were mild irritants, and 8 were non-irritants. The same set of PCs was evaluated using the SIT and were classified as non-irritants to skin. These results are consistent with the BMS historical in vivo results showing a very low number of PCs as skin irritants.Conclusions: This tiered in vitro testing strategy, which replaces the use of animal studies, was found to be reasonably accurate in its predictive capacity when compared to historical in vivo results and represents a conservative and reliable platform that can be utilized for the prediction of ocular and dermal irritation/corrosion potential of PCs and for subsequent GHS classification and worker safety hazard communications. 相似文献
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介绍我院临床药师开展临床药学服务的的工作内容及效果.探讨临床药学服务在促进合理用药和医院药学发展中起的重要作用. 相似文献
65.
目的比较中、美、英、欧药典制药用水微生物检查法,为《中国药典》的修订提供参考,为推动制药用水微生物检查法与国际接轨提供合理化建议。方法通过采用不同的检查方法、培养基、培养条件对20个样本进行实验,并对不同实验条件进行两两配对的 t检验,统计分析比较方法的差异性。结果采用R2A培养基,30~35℃,120 h ,薄膜过滤法,培养效果较好。同时,《中国药典》2010年版的方法可行。结论可以采用 R2A 培养基、30~35℃、120 h、薄膜过滤法对制药用水进行微生物限度检查。 相似文献
66.
利用Nvivo11软件对国内58所和美国30所药学院校的培养目标文本进行质性分析,探索了两国培养目标文本的结构和差异,根据学生发展核心素质理论、核心领域能力、领导技能等设计了适合我国药学院校培养目标构建的结构模型,有助于方便准确的构建出符合学校特色且完善的药学硕士研究生培养目标。本研究还提出国内药学院校在构建培养目标时,应更加尊重学校历史特色,同时注重研究生全球化、领导力意识、创新创业意识、人文素质、责任担当等方面的要求,才能保障研究生全面发展,增强研究生的职业竞争优势。 相似文献
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