Image analysis was used to measure particle size distributions (PSDs) of ensembles of 425 to 1400 µm‐size materials. Repeatability of a measurement, suitable sample sizes, and methods of sampling were assessed. Two lots of inert spheres were compared prior to drug layering in a Glatt GPCG‐5 rotor. The differences in PSD in the starting materials were reflected in the rotor‐granulated products. Such detailed information was not available from sieving with U.S. standard wire mesh sieves. The products from the rotor process were polymer‐coated in a Wurster process in a Glatt GPCG‐3, 4‐in. Wurster. The resolution of the technique was sufficient to measure differences in diameter equating to 4‐µm coat thickness, which resulted from applying 2% polymer coat weight. The utility of the technique for monitoring commercial scale processes was demonstrated by measuring diameter after layering drug onto nonpareils in a Glatt RG‐150 rotor, and by measuring the diameter after application of a polymer solution in a Glatt 46‐in. Wurster coating process. The similarity of samples removed from the sample port in situ and samples from the batch suggested that processes in the fluid bed are intensively mixed and inherently random. 相似文献
目的:评价聚精颗粒治疗弱精子症患者的疗效。方法:36例弱精子症患者,年龄24~39岁,平均29.1岁。口服聚精颗粒,温开水冲服120 m l/次,2次/d,共3个月。分别于治疗前及治疗3个月末,采用DNA荧光染色精子动(静)态图像分析系统进行精液参数分析。结果:完成治疗的31例患者中,除3例精液质量未见明显改善外,其余28例精液质量均明显改善。其中,除精子密度治疗前后差异无显著性外(P>0.05),a级精子、(a+b)级精子、精子活率等主要精液参数指标,在聚精颗粒治疗3个月后均有显著改善(P均<0.01)。治疗期间及治疗后随访有5例配偶怀孕,其中1例己正常分娩。结论:聚精颗粒对弱精子症具有较好的疗效。 相似文献
Purpose: To present a case report on the presence of an ectopic mandibular third molar (EMTM), the surgical treatment, and outcome.
Case report: A 63-year-old woman presented with right preauricular facial swelling, limited jaw function, and pain. Radiographic assessment demonstrated an EMTM positioned in the superoposterior aspect of the ramus. Radiographically, there was a bony tunnel extending from the third molar to distal of the second molar. The patient was treated by an intraoral approach on the medial aspect of the ramus for removal of the ectopic third molar, as well as the tissue in the bony tunnel.
Results: The patient healed uneventfully. The soft tissue in the bony canal was granulation tissue, and nerve function was preserved. A literature search of EMTMs was conducted identifying 17 reported cases.
Conclusion: Three-dimensional imaging in the management of EMTM can be beneficial in identifying position of the tooth, associated pathology, and identifying the position of neurovascular structures to aid in removal of the ectopic tooth. 相似文献
Summary A series of experiments with alloxan-diabetic and control rats was done in order to investigate growth of cotton-pellet granulomas and incorporation rate of35S-sulphate into sulphated mucopolysaccharides of the granulation tissue. — It could be demonstrated that in the alloxan-diabetic animals there was not only markedly less formation of granulation tissue, but a pronounced blocking of synthesis of sulphated mucopolysaccharides in the granulation tissue as well. — These findings are assumed to be caused by the lack of insulin in alloxan diabetes, and to be related to the delayed wound-healing in patients with badly controlled diabetes mellitus.This work was supported by the Landesversiche-rungsanstalt Westfalen, the Bergbauberufsgenossenschaft Bochum and the Deutschen Forschungsgemeinschaft. 相似文献
A 56-year-old man presented with a 6-mo history of headache. Although neurological and laboratory examinations were normal, computed tomography (CT) scan was performed which revealed multiple occipital osteolytic lesions, which were suspected to be multiple myeloma. Subsequently nuclear magnetic resonance imaging (MRI) showed that these lesions presented with a cerebrospinal fluid (CSF)-like signal intensity, no diffusional restriction and intrinsic mass-like enhancement on conventional sequences were seen. T2 relaxation time was similar to that of CSF in the ventricles and adjacent subarachnoid space on T2-mapping. Single photon emission CT with 99m Tc-Methyl diphosphonate was performed which revealed no increased radiotracing accumulation. Finally, these lesions were diagnosed as mutiple arachnoid granulations (AGs). The headache was treated symptomatically with medical therapy. On follow up examination after 6 mo no evidence of tumor was detected. This report aimed to illustrate the appearance and differentiation of occipital defects caused by multiple AGs on CT and MRI, with emphasis on the findings from T2 mapping. 相似文献