中药烧伤膏I号联合削痂治疗小面积Ⅲ度烧伤的疗效观察

目的　探讨中药烧伤膏1号联合削痂治疗小面积Ⅲ度烧的疗效。方法　常规清创和削、切痂后,局部贴敷中药烧伤膏Ⅰ号,创面溶脱,液化前隔日换药,以后每日换药直至创面愈合。结果　全部病例均未植皮,创面愈合良好,愈合时间25-48d,82％(59/72)病例在5周内治愈。结论　该法不需植皮,愈合快,瘢痕轻,不失为是治疗小面积深度烧伤的有效方法之一。     

Topical calcitriol – studies on local tolerance and systemic safety

Calcitriol 3 μg g⁻¹ ointment (Silkis ointment®, Galderma Laboratories) is a new treatment for psoriasis. Calcitriol is the biologically active metabolite of vitamin D₃. It induces keratinocyte differentiation, inhibits keratinocyte, T-cell and fibroblast proliferation, and inhibits the production of some inflammatory mediators, all contributors to the pathogenesis of psoriasis. Preclinical studies have shown an effect of topical calcitriol on calcium homeostasis at doses higher than those in clinical use. No adverse local events were observed when calcitriol was applied to animal skin. Phase I clinical studies confirmed that calcitriol 3 μg g⁻¹ ointment is well tolerated in humans. These studies have demonstrated that at the minimal effective concentration of 3 μg g⁻¹, calcitriol ointment has no discernible photosensitizing or phototoxic potential and no skin irritant or allergic potential in healthy volunteers. Its low systemic absorption through human skin is unlikely to significantly affect calcium homeostasis. This paper summarizes the findings of the preclinical and early clinical studies that provided the foundation of the later Phase II and III clinical trials on efficacy and safety with topical calcitriol 3 μg g⁻¹ ointment for the treatment of plaque psoriasis.     

中药穴位贴敷抗小鼠艾氏腹水癌作用的实验研究

进行中药抗癌腹水膏穴位贴敷抗小鼠艾氏腹水癌作用的实验研究，结果显示：该疗法能明显改善荷瘤小鼠的一般状况，抑制荷瘤小鼠的腹水量，不同程度地延长荷瘤小鼠的生存期，并使荷瘤小鼠腹水癌细胞数量减少，免疫功能增强。     

六神软膏的研制

为满足临床需要，改变传统剂型。方法：对常用水溶性基质进行筛选，运用正交试验法优选基质最佳配方。采用消化后氧化－还原滴定的方法测定软膏中雄黄的含量。结果：选用甲基纤维素和丙二醇为软膏基质。制备工艺可行，制剂稳定，无刺激性。质量控制方法可靠，平均回收率为9904％，RSIJ为0.34％。结论：该制剂可用于临床。     

Tacrolimus ointment improves psoriasis in a microplaque assay

Tacrolimus (FK506) is an effective and well tolerated immunosuppressant used to prevent allograft rejection. We describe the evaluation of two tacrolimus ointment formulations for treatment of chronic plaque-type psoriasis. This was a microplaque assay with randomized, double-blind design. Sixteen patients (15 men, one woman, all white and 28-69 years old) with chronic plaque-type psoriasis participated. Six different ointments were applied to discrete microplaques, 17 mm in diameter, on a descaled psoriasis lesion: these were tacrolimus ointment with diisopropyl adipate as penetration enhancer, tacrolimus ointment without diisopropyl adipate, 0.1% betamethasone 17alpha-valerate ointment, 0.005% calcipotriol ointment and, as controls, the ointment bases for tacrolimus and betamethasone. Ointments were reapplied and the area was sealed every 2-3 days during the 14-day treatment period. After 7 and 14 days, erythema and infiltration were graded on a scale of 0-4, and superficial blood flow was measured with a laser Doppler flowmeter. Epidermal thickness was measured histologically at the end of treatment. Compared with the vehicle controls, sites treated with tacrolimus ointment (with or without penetration enhancer) showed a significant reduction in erythema and infiltration (P < 0. 001), a significant reduction in superficial blood flow (P < 0.01) and a significant decrease in epidermal thickness (P < or = 0.001). Results for betamethasone and calcipotriol, when compared with the vehicle controls, were similar. These results suggest that, under conditions of descaling and occlusion, tacrolimus ointment is effective in the treatment of psoriasis.     

几种常用烧伤外用制剂对感染防治的实验观察

目的研究几种常用的烧伤外用制剂的抑菌作用。方法分别在灰尘污染的动物烧伤创面、烧伤肉芽创面应用几种烧伤外用药,通过组织细菌定量培养,比较各制剂的抑菌效果。结果10%聚维酮碘软膏能有效抑制细菌生长,而0.5%聚维酮碘溶液、10%磺胺嘧啶银混悬液效果欠佳。结论10%聚维酮碘软膏是一种良好的烧伤外用药。     

防疤烧伤膏对大鼠伤口愈合的影响

目的：观察防疤烧伤膏对大鼠创面修复的影响。方法：采用大鼠皮肤切割伤模型。创面外用防疤烧伤膏，并采用碱性成纤维细胞生长因子（basic fibroblast growth factor,bFGF)和空白处理作为阳性和阴性对照。透明膜标记称量法和注水法记录伤后3d,7d和14d创面面积和伤腔容积，伤后7d和14d取创面组织进行组织学检查。结果 防疤烧伤膏能够减轻伤口炎症反应，促进坏死组织脱落，缩短伤口愈合时间。结论：外用防疤烧伤膏对创面修复有促进作用。     

自拟蓉肤消白膏治疗外阴慢性单纯性苔藓的临床观察

[目的] 评价外用蓉肤消白膏治疗外阴慢性单纯性苔藓的临床效果,分析其临床疗效和安全性。[方法] 将就诊于石家庄市中医院妇二科门诊的外阴慢性单纯性苔藓（湿热型）患者80例,应用随机数字表法将其分为治疗组和对照组各40例。治疗组给予蓉肤消白膏涂擦治疗,对照组给予丁酸氢化可的松乳膏涂擦治疗。观察患者症状体征在治疗1、2个月的变化情况,及治疗前、治疗2个月两组患者中医症状积分、T淋巴细胞亚群绝对计数的变化及不良反应发生情况。[结果] 治疗后两组临床疗效指数无统计学差异（P>0.05）,治疗1、2个月,两组的瘙痒症状、皮肤弹性、病变范围积分、皮肤颜色积分均有下降,治疗组在皮肤弹性、皮肤颜色改善情况优于对照组（P<0.05）。治疗后两组患者血清T淋巴细胞亚群绝对计数与治疗前相比差异有统计学意义（P<0.05）,并且治疗组优于对照组。治疗后两组中医症状总积分比较,两组组内比较,差异均有统计学意义（P<0.05）;两组治疗后组间比较,差异有统计学意义（P<0.05）。[结论] 蓉肤消白膏治疗外阴慢性单纯性苔藓,在改善患者皮肤弹性、皮肤颜色方面疗效较好,且可改善患者的免疫功能,具有较好的安全性。