西北农村不同民族之间糖尿病患病情况分析

目的了解西北农村回、汉民族糖尿病及其前期的患病情况和可能的影响因素。方法通过整群随机抽样确定调查人群,经手指血空腹、餐后2 h血糖初筛后确定高危人群,在高危人群中进行标准75 g口服葡萄糖耐量试验(oral glucose tolerancetest,OGTT),确定糖尿病及其前期阶段的患病人群。通过"糖尿病流行病学调查表"对抽样对象进行问卷调查,了解基本人口学资料,并进行统计分析。结果降低空腹血糖的切入点至5.6 mmol/L后发现,糖尿病及其前期患病情况在民族(P=0.001)、性别(P=0.047)和年龄分布(P=0.001)等方面差异有统计学意义。不同民族和性别的患者糖尿病及其前期阶段患病情况不同,回族患者女性高于男性(P=0.022)、汉族患者男性高于女性(P=0.001)。回族患者糖尿病标准化患病率(5.87%)高于汉族患者(3.07%)。结论不同民族的患者糖尿病及其前期的患病情况在性别、年龄分布上差异有统计学意义,生活习惯不同可能为重要因素。被调查人群的糖尿病相关知识知晓率普遍较低。     

止泻灵颗粒质量标准研究

目的 制定止泻灵颗粒质量标准.方法 采用薄层色谱法对处方中的甘草进行定性鉴别;采用高效液相色谱法对橙皮苷进行含量测定.结果 采用薄层色谱法能够检出甘草;含量测定橙皮苷的线性范围为0.35～7.0μg,r=0.9997,平均回收率为98.2%;RSD=0.95(n=9).结论 所建立的方法可准确地进行定性、定量检测,可用于该制剂的质量控制.     

Seguimiento de la actividad clínica y del daño orgánico acumulado en una cohorte de pacientes con lupus eritematoso sistémico de la península de Yucatán,México (1995-2016)

IntroductionSystemic lupus erythematosus (SLE) is an autoimmune with variable severity, common in Hispanic and African-American individuals.ObjectiveTo know the clinical activity and the accumulated damage, as well as the prevalence and incidence, in a dynamic cohort of patients with SLE from the Yucatan Peninsula (1995-2016).Patients and methodsA cohort of 200 patients with SLE, medical service beneficiaries of the ISSSTE Regional Hospital of Mérida, Yucatán, was analyzed for 22 years. Disease activity and accumulated damage were evaluated using the MEX-SLEDAI scale and the SLICC-ACR-DI, respectively, and its correlation with clinical and demographic variables.Results185 female and 15 male patients were analyzed. Average accumulated damage and activity indices during follow-up were 4.63 and 1.10, respectively. The activity index was significantly lower in females compared to males (4.36 vs 7.43), and the accumulated damage did not present a difference by sex. The manifestations associated with greater activity were the mucocutaneous and articular ones, and the organs with the greatest accumulated damage were the musculoskeletal, neurological and gonadal. A relationship between the indices was found with the evolution time, remissions / reactivations, and persistent activity. Mortality was related to persistent activity due to systemic vascular complications and kidney and liver failure. The annual incidence and prevalence of SLE calculated was 2.86% and 48.43% in Yucatán Peninsula.ConclusionsThe patients presented persistent activity, with mild to moderate reactivations, and accumulated damage more aggressive in men. The clinical activity decreases and increases the accumulated damage at a longer evolution time, with less kidney disease and greater survival, which suggests a more benign course in the population of the Yucatan Peninsula.