全文获取类型
收费全文 | 128篇 |
免费 | 19篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 3篇 |
基础医学 | 2篇 |
口腔科学 | 1篇 |
临床医学 | 11篇 |
内科学 | 38篇 |
皮肤病学 | 4篇 |
特种医学 | 2篇 |
外科学 | 5篇 |
综合类 | 25篇 |
预防医学 | 2篇 |
药学 | 43篇 |
中国医学 | 18篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 9篇 |
2020年 | 10篇 |
2019年 | 1篇 |
2018年 | 4篇 |
2017年 | 6篇 |
2016年 | 9篇 |
2015年 | 8篇 |
2014年 | 6篇 |
2013年 | 27篇 |
2012年 | 4篇 |
2011年 | 8篇 |
2010年 | 3篇 |
2009年 | 5篇 |
2008年 | 3篇 |
2007年 | 6篇 |
2006年 | 4篇 |
2005年 | 3篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2002年 | 9篇 |
2001年 | 1篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1996年 | 3篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1987年 | 1篇 |
排序方式: 共有154条查询结果,搜索用时 46 毫秒
91.
目的 观察复方苦参结肠溶胶囊治疗溃疡性结肠炎(ulcerative colitis, UC)湿热内蕴证的临床疗效及安全性,并同美沙拉嗪缓释颗粒(艾迪莎)进行比较。 相似文献
92.
肠炎康联合美沙拉嗪治疗溃疡性结肠炎 总被引:2,自引:1,他引:1
目的:比较肠炎康联合美沙拉嗪与美沙拉嗪治疗溃疡性结肠炎的疗效,为临床治疗溃疡性结肠炎提供合理用药的建议.方法:将吉林大学第一医院2010年6月-2011年5月门诊收治的溃疡性结肠炎患者90例,随机分为治疗组45例和对照组45例,分别接受肠炎康联合美沙拉嗪与美沙拉嗪的治疗方法,用药后对两组的治疗有效率、结肠镜下形态变化及C-反应蛋白及血沉等进行比较,评价其疗效及安全性.结果:两组治疗后的有效率、结肠镜下形态变化比较均具有统计学意义(P<0.05).结论:肠炎康联合美沙拉嗪的疗效优于美沙拉嗪,值得临床推广应用. 相似文献
93.
《Drug delivery》2013,20(4):208-213
In this work, the design and evaluation of a colonic drug delivery system containing mesalamine (M) is presented. The main goal was to enable M to reach the first part of the colon, where the drug could then be released. To facilitate this, a tablet core was coated with two thin layers. The first compounded by chitosan, which was responsible for core protection in the small intestine until it reached the colon. Once at the colon, microbiological enzymatic activity of the caecal content would degrade the Ch layer, thus triggering drug release. The second layer, the outer one, was compounded with Eudragit L100 (EL), with its function being to avoid the dissolution of the Ch-covered core along the gastro intestinal tract (GIT). In order to achieve a modulated drug release, carbomer P934 (1%) was also included. Dissolution studies showed that the formulation seemed to behave as predicted. The amount of M released from the coated tablet was less than 10% at pH?=?1.2 and 6.8. However, when the coated tablet was evaluated in a medium with a caecal content of pH?=?7.4, the M delivery was immediately triggered owing to enzymatic activity of the microflora. In this medium, ~ 60% of M was released in a period of 3?h. Although these results are promising, further studies are still necessary to evaluate the possible in vitro/in vivo correlations. 相似文献
94.
《Expert Review of Gastroenterology & Hepatology》2013,7(10):1293-1304
Acute diverticulitis, defined as acute inflammation of a colonic diverticulum, is a common emergency presentation managed by both surgeons and physicians. There have been advances in the medical treatments offered to patients in recent years. Factors predisposing individuals to the development of acute diverticulitis include obesity, smoking, lack of physical activity and medication use, such as NSAIDs. Although widely used, there is limited evidence on the efficacy of individual antibiotic regimens and antibiotic treatment may not be required in all patients. Mesalazine seems to be the only effective treatment for the primary prevention of acute diverticulitis. Finally, evidence of effective measures for the prevention of recurrence is lacking. Furthermore, high-quality randomized controlled trials are required for medical treatments in patients with acute diverticulitis, if management is to be evidence based. 相似文献
95.
96.
目的:观察美沙拉嗪联合低分子肝素治疗溃疡性结肠炎的临床疗效。方法:选择40例中重度溃疡性结肠炎患者,随机分为两组:A组为对照组,20例,美沙拉嗪,4g/d,日四次口服治疗,B组为实验组,20例,美沙拉嗪,4g/d,日四口服,联合低分子肝素,5000单影日二次皮下注射1周治疗。2周后观察治疗前后的结肠镜下改变及血清CRP变化。结果:实验组的总有效率高于对照组,但无明显统计学差异;实验组的完全缓解率高于对照组且有统计学意义。实验组的血清CRP水平明显降低,随访6个月后仍维持较低水平。结论:在中重度溃疡性结肠炎治疗中,美沙拉嗪联合低分子肝素临床疗效要优于单用美沙拉嗪,完全缓解率高,且远期疗效较好。 相似文献
97.
《Scandinavian journal of gastroenterology》2013,48(10):863-868
Rijk MCM, van Schaik A, van Tongeren JHM. Disposition of mesalazine from mesalazine-delivering drugs in patients with inflammatory bowel disease, with and without diarrhoea. Scand J Gastroenterol 1992;27:863-868.The disposition of mesalazine from the azo compounds sulphasalazine and olsalazine (Dipentum®) and from the slow-release mesalazine drugs Pentasa®, Asacol®, and Salofalk® was studied in 20 patients with inflammatory bowel disease. Ten of them had diarrhoea, and 10 had normal stools. On the last 2 days of a 7-day maintenance treatment with each of the study drugs urine and faeces were collected for determination of mesalazine, acetyl-mesalazine, and unsplit azo compound. In patients with and without diarrhoea the urinary and the faecal excretion of acetyl-mesalazine was lowest during treatment with olsalazine. The proportion of acetyl-mesalazine in faeces was highest during treatment with Pentasa in both groups. The presence of diarrhoea was associated with a decrease in the proportion of acetyl-mesalazine in faeces during treatment with all drugs, not significant only for Pentasa. The proportion of unsplit azo compound in faeces increased in the case of diarrhoea to almost 50%. It is concluded that in patients with inflammatory bowel disease diarrhoea substantially influences the disposition from ail these drugs except Pentasa. 相似文献
98.
敛疡汤保留灌肠治疗溃疡性结肠炎临床研究 总被引:1,自引:0,他引:1
目的:探讨敛疡汤保留灌肠治疗溃疡性结肠炎的临床疗效。方法:选取溃疡性结肠炎患者50例,随机分为治疗组和对照组,每组各25例,两组均予以参白汤口服,治疗组采用敛疡汤保留灌肠,对照组采用美沙拉嗪缓释颗粒保留灌肠,疗程均为3个月,观察两组有效率、疾病活动指数及结肠镜下评分情况,并记录不良反应。结果:两组有效率比较,无显著差异( P >0.05);两组治疗前后的疾病活动指数及结肠镜下评分均较治疗前明显改善,差异有统计学意义(P <0.05),且治疗组优于对照组(P <0.05);治疗组未见不良反应,对照组不良反应发生率16.0%。结论:敛疡汤保留灌肠治疗溃疡性结肠炎效果显著,且不良反应少。 相似文献
99.
武星汝 《青岛大学医学院学报》2014,(1):78-79
目的 观察美沙拉嗪联合氟哌噻吨美利曲辛治疗难治性腹泻型肠易激综合征(I BS)病人的临床效果。方法 选取84例难治性腹泻型IBS病人,随机分为对照组和治疗组各42例。对照组给予美沙拉嗪治疗,治疗组同时给予氟哌噻吨美利曲辛治疗,疗程均为4周。结果 治疗组总有效率为95.2%,显著高于对照组的71.4%,差异有显著性(V2=6.010,P〈0.05)。结论 美沙拉嗪联合氟哌噻吨美利曲辛治疗难治性I BS临床效果显著,可有效缓解症状,宜在临床推广。 相似文献
100.
美沙拉秦治疗溃疡性结肠炎的多中心研究 总被引:9,自引:1,他引:8
欧平安 郑松柏 徐富星 林庚金 陆玮 钱立平 孙旭 蔡洪培 张兴荣 朱瑞龙 陈韦忠 胡和平 陈世耀 汪佩文 唐振铎 袁耀宗 蒋西华 陈维雄 汪敏 朱舜时 陈启雅 姜靖寰 王秀玲 许幼如 张德中 《中国新药与临床杂志》1998,17(5):283-284
目的:观察美沙拉秦对我国溃疡性结肠炎病人的疗效。方法:溃疡性结肠炎病人100例,其中41例单纯溃疡性直肠炎为栓剂组,其他59例为片剂组。栓剂组(男性24例,女性17例,年龄43±s11a)予美沙拉秦栓剂1.0g纳肛,bid,疗程8wk;片剂组(男性29例,女性30例,年龄44±14a)予美沙拉秦缓释片0.5~1.0g,po,tid~qid,疗程8wk;疗程结束后复查肠镜并作活检。结果:2组病人治疗后肠镜及组织学所见均显著改善,栓剂组总有效率为98%,片剂组为95%,前者无不良反应,后者不良反应轻微。结论:美沙拉秦治疗我国溃疡性结肠炎疗效显著而又安全。 相似文献