来氟米特治疗强直性脊柱炎伴周围关节炎

目的 探讨来氟米特(LFM)治疗难治性强直性脊柱炎(AS)伴周围关节炎的疗效和安全性.方法 采用患者单盲、随机及安慰剂对照的临床试验研究方法,将67例经柳氮磺胺吡啶(SSZ)和非甾体抗炎药(NSAIDs)治疗无效的活动性AS伴周围关节炎患者随机分为两组,分别接受LFM和安慰剂治疗,疗程24周,观察疗效和不良反应.结果 ...     

中西医结合治疗类风湿关节炎30例

目的：观察健脾祛湿活血法中西医结合治疗类风湿关节炎的临床疗效。方法：选符合标准的该病患者60例,随机分为两组。治疗组予来氟米特合健脾祛湿活血法中药治疗;对照组仅予来氟米特。两组均治疗12周。结果：治疗组缓解6例,显效14例,有效8例,无效2例,总有效率93.3%（95%C I=77.9%~99.8%）;对照组缓解4例,显效12例,有效8例,无效6例,总有效率80.0%（95%C I=61.4%~92.3%）;两组综合疗效比较（u=1.251 8,P=0.210 7）,差异未达显著性意义;可改善部分临床疗效指标。结论：健脾祛湿活血法中西医结合治疗类风湿关节炎的临床疗效优于来氟米特的结论不确定,其收益为OR=0.29（95%C I=0.05~1.55）;NNT=8（95%C I=3.3~33.3）。     

Leflunomide: Traditional immunosuppressant with concurrent antiviral effects

Leflunomide is a classic disease-modifying anti-rheumatic drug that is widely used to treat autoimmune diseases. Studies also show its antiviral effects in in vitro and/or in vivo experiments. Considering glucocorticoids, immunosuppressants and newly emerged antibodies commonly used in autoimmune diseases and autoinflammatory disorders bring risk of infection such as viral infection, leflunomide with combination of anti-viral and immunosuppressive features to maintain the balance between infection and anti-inflammation are attractive. Here we summarize the actions and mechanisms of leflunomide in immunoregulatory and antiviral effects.