大黄清胃冲剂活性成分提取工艺的均匀设计优化选择

目的 探讨大黄清胃冲剂活性成分提取分离的优化工艺条件。方法 以游离蒽醌提取率为定量指标,通过４种生长黄煎煮方法的初步筛选,确定浸渍溶剂、浸渍时间、回流溶剂及回流时间为考察因素,并为Ｕ９（９＾６）均匀表设计试验。结果 大黄提取优化工艺条件为７０％乙醇浸润１４ｈ和回流提取８０ｍｉｎ。结论 工艺条件可以用于大黄清胃冲剂的生产制备。     

对促宫颈成熟与引产孕产妇的全程分娩管理模式

目的 探讨在全程分娩管理模式下,为孕产妇提供促宫颈成熟与引产服务的可行性。方法 选择2018年1月1日至2020年12月31日,在南京大学医学院附属鼓楼医院接受待产、分娩到产后康复(LDRP)一体化全程分娩管理模式(以下简称为LDRP管理)的848例孕产妇为研究对象。根据孕产妇进入产房时是否进入自然产程,将其分为自然临产组(n=441)和引产组(n=407)。采用回顾性分析法,对2组孕产妇的一般临床资料,如分娩年龄、孕次、孕龄、妊娠并发症,以及母儿结局进行比较。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》的要求,并经过南京大学医学院附属鼓楼医院伦理委员会审核批准(审批文号：201702001)。结果 (1)2组孕产妇分娩年龄、孕次和高龄孕产妇所占比例比较,差异无统计学意义(P>0.05)。2组孕产妇分娩孕龄、经产妇占比、早产率、缩宫素使用率、分娩时长比较,差异有统计学意义(P<0.05)。(2)引产组孕产妇均使用前列腺素类药物促宫颈成熟或缩宫素进行引产,其中使用地诺前列酮栓、米索前列醇、缩宫素、地诺前列酮栓+米索前列醇分别为26.5%(108/407)、...     

Photocatalytic Hydrogen Evolution from Artificial Seawater Splitting over Amorphous Carbon Nitride: Optimization and Process Parameters Study via Response Surface Modeling

Photocatalytic water splitting has garnered tremendous attention for its capability to produce clean and renewable H₂ fuel from inexhaustible solar energy. Until now, most research has focused on scarce pure water as the source of H₂, which is not consistent with the concept of sustainable energy. Hence, the importance of photocatalytic splitting of abundant seawater in alleviating the issue of pure water shortages. However, seawater contains a wide variety of ionic components which have unknown effects on photocatalytic H₂ production. This work investigates photocatalytic seawater splitting conditions using environmentally friendly amorphous carbon nitride (ACN) as the photocatalyst. The individual effects of catalyst loading (X₁), sacrificial reagent concentration (X₂), salinity (X₃), and their interactive effects were studied via the Box–Behnken design in response surface modeling towards the H₂ evolution reaction (HER) from photocatalytic artificial seawater splitting. A second-order polynomial regression model is predicted from experimental data where the variance analysis of the regressions shows that the linear term (X₁, X₂), the two-way interaction term X₁X₂, and all the quadratic terms (X₁₂, X₂₂, X₂₃) pose significant effects towards the response of the HER rate. Numerical optimization suggests that the highest HER rate is 7.16 µmol/h, achievable by dosing 2.55 g/L of ACN in 45.06 g sea salt/L aqueous solution containing 17.46 vol% of triethanolamine. Based on the outcome of our findings, an apparent effect of salt ions on the adsorption behavior of the photocatalyst in seawater splitting with a sacrificial reagent has been postulated.     

Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto’s Thyroiditis

The impact of selenium on the course of Hashimoto’s thyroiditis (HT) was mainly assessed by monitoring the titer of antithyroid autoantibodies in most of the studies conducted hitherto. On the other hand, the imbalance in activity of T cells such as Th1, Th2, Th17, and Treg may be relevant in the pathogenesis of this disease. Hence, the assessment of changes in the secretion of cytokines by these cells during selenium supplementation in patients with HT seems to be an important issue and was the main goal of this study. A further aim was to search for correlations among these cytokines, as well as markers of thyroid function, selenium/iodine status in the body, and other biochemical parameters. The group of 29 women with newly diagnosed Hashimoto’s thyroiditis was supplemented with selenium in a dose of 100 µg/day for 6 months. Immunological parameters: interferon γ, tumor necrosis factor α, chemokine CXCL10, interleukin 4, interleukin 1β, interleukin 17, transforming growth factor β, and C-reactive protein, as well as selenium status parameters were determined in serum twice, i.e., before and after supplementation. Selenium supplementation was associated with a change in the production of two cytokines: interferon γ and interleukin 1β, for which a decrease and an increase in concentration were observed, respectively. The partial least squares (PLS) model revealed the presence of many relevant correlations among analyzed parameters. The stage of HT development, degree of thyroid dysfunction, and selenium supplementation of diet are interdependent factors which shape the profile of some cytokines secreted by cells participating in the autoimmunity process.     

黄芩素制备工艺研究

目的研究由黄芩苷制备黄芩素的最佳工艺。方法采用直接酸水解法和热裂解法相比较，以黄芩素的含量和得率为指标，对其制备工艺进行优化。结果热裂解方法中当温度超过200℃时，可以获得含量为94．47％以上的黄芩素，得率不高于41．64％，而直接酸水解方法获得黄芩素的含量为92．15％以上，且得率为66．03％以上。结论直接酸水解法制备黄芩素工艺简单可行，得率较高，实用性强。     

低温等离子辅助下重塑钩突的内镜鼻窦手术的疗效

我科20ll-12-2012-11对32例经鼻内镜和鼻窦冠状位CT检查确诊为慢性鼻一鼻窦炎伴（或不伴）鼻息肉患者行低温等离子辅助下重塑钩突的内镜鼻窦手术,疗效满意,报告如下。     

Working with tactile massage--a grounded theory about the energy controlling system

The purpose of this study was to acquire a theoretical understanding of what it is like to work as a tactile massage therapist (TMT). There is insufficient knowledge in this area—despite increasing demand and implementation of tactile massage; so 26 female TMTs were interviewed (6 interview groups in Stockholm County). Grounded theory was used to analyse the data. The analysis resulted in a theoretical model that explains how TMTs individually underwent a transformation in which they learned about the energy-controlling system (energy takers, energy returners, and energy controllers) and managed to implement this demanding treatment, while maintaining health and inner balance in order to have total presence during treatment sessions. Results showed that total presence was crucial for implementing high-quality treatment, and inability to control energy may pose a risk to inner balance and health among TMTs.     

集成数据校正的乙烯装置进料数据采集

乙烯装置的模拟需要有准确的裂解炉进料信息,而通过对进料系统的模拟计算可以从较易测得的原料信息得到所需的裂解炉进料信息。通过对某石化企业乙烯装置进料系统进行模拟,根据体系特点集成数据校正以解决流量测量数据的不平衡和不完整的问题,利用数据的空间冗余提高了模拟计算所用数据的准确性和可靠性,并针对体系的特殊性提出了数据校正过程中出现几类负值的处理方法,最后模拟得到所需的裂解炉进料性质数据。     

环境侵权投诉中健康损害判定程序研究

提出环境污染健康损害判定工作程序及步骤,给出已知污染物或未知污染物造成健康损害判定工作框图,并提出健康损害判定:①必须经环境保护主管部门进行资质认定的环境污染健康损害判定机构承担;②具有健康损害判定资质的机构应建立相应专家组;③健康损害判定专家组按相关标准根据医学诊断、环境证据及因果关系进行健康损害判定。     

Tribocorrosion and Abrasive Wear Test of 22MnCrB5 Hot-Formed Steel

The article presents the results of research on abrasive and tribocorrosion wear of boron steel. This type of steel is used in the automotive and agricultural industries for the production of tools working in soil. The main goal of the article is the evaluation of tribocorrosion and abrasive wear for hot-formed 22MnCrB5 steel and a comparison of the obtained results with test results for steel in a cold-formed state. The spinning bowl method to determine the wear of samples working in the abrasive mass was used. Furthermore, a stand developed based on the ball-on-plate system allows to determine the wear during the interaction of friction and corrosion. After the hot-forming process, 22MnCrB5 steel was three times more resistant for the abrasive wear than steel without this treatment. The average wear intensity for 22MnCrB5 untreated steel was 0.00046 g per km, while for 22MnCrB5 hot-formed steel it was 0.00014 g per km. The tribocorrosion tests show that the wear trace of hot-formed 22MnCrB5 steel was about 7.03 µm, and for cold-formed 22MnCrB5 steel a 12.11 µm trace was noticed. The hot-forming method allows to obtain the desired shape of the machine element and improves the anti-wear and anti-corrosion properties for boron steel.