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41.
42.
小檗碱对大鼠再灌心律失常及钙调节的作用 总被引:8,自引:0,他引:8
小檗碱(Ber,10mg·kg-1)使缺血/再灌后VT发生率明显降低,持续时间明显缩短,无1例发生VF及死亡,与对照组比较差异有显著性。离体实验表明:小檗碱(30μmol·L-1),能抑制高钙条件下Ca2+内流,而增加低钙条件下的Ca2+内流。结果表明:小檗碱具有预防再灌心律失常作用;不同Ca2+浓度能够影响心肌45Ca内流;小檗碱对心肌Ca2+内流有双向调节作用,尤其在高Ca2+条件下,降低45Ca内流可能是其抗心律失常作用机制之一。 相似文献
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M. Vincenzi T. Morlino P. Allegri E. Barbieri F. Cappelletti U. Delio R. Ometto P. Maiolino 《Clinical cardiology》1981,4(1):15-21
Alterations in cardiovascular function induced by the acute intravenous administration of verapamil (5 or 10 mg) in 52 patients (29 with ischemic heart disease and 23 without heart disease) were evaluated with use of invasive techniques (right and left heart catheterization, left ventricular cineangiography, and coronary arteriography). The most significant changes were represented by a decrease in systemic vascular resistance and systemic arterial pressure, and an increase in heart rate and cardiac output. Contractility indexes were not depressed in either group, and altered ventricular wall motion tended to improve to a slightly smaller degree than in patients treated with nitroglycerin. The use of verapamil in patients with ischemic heart disease appears to be safe, and concern about the negative inotropic influences in humans no longer seems justified. 相似文献
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目的 :探讨内皮素 (ET)、在新生儿缺氧缺血性脑病 (HIE)中的作用及与肺功能关系。方法 :将 4 2例 HIE患儿按病情分为轻、中、重三组 ,各组均在入院后第 2天采用婴儿体描箱进行潮气呼吸分析、有效气道阻力及功能残气量等肺功能测定同时用放射免疫法测定血浆 ET水平。结果 :中、重度 HIE组血浆 ET水平均高于轻度组及对照组 ;中、重度HIE组肺功能测定提示 TPTEF/ TE、VPEF/ VE、PEF的下降。重度 HIE组潮气量下降 ,有效气道阻力增高。结论 :血浆ET水平增高与 HIE病情的严重程度相一致 ,肺功能检测指标可以解释血浆 ET水平的增高在新生儿中、重度 HIE发生肺动脉高压及急性肺损伤中起的作用 ,对 HIE临床治疗有一定的指导作用 相似文献
47.
尼莫地平复方丹参注射液治疗新生儿缺氧缺血性脑病疗效观察 总被引:1,自引:0,他引:1
目的观察尼莫地平联合复方丹参注射液治疗新生儿缺氧缺血性脑病(HIE)的疗效.方法 128例HIE患儿随机分为复方丹参注射液组32例,尼莫地平组,尼莫地平加复方丹参注射液,与对照组.结果复方丹参注射液组、尼莫地平组、尼莫地平加复方丹参注射液治疗组总有效率分别为81.3%(26/32)、80.0%(24/30)、97.1%(34/35),对照组总有效率为51.6%(16/31),P<0.05.结论尼莫地平与复方丹参注射液在治疗HIE时有协同作用,疗效显著,未见副作用发生. 相似文献
48.
采用火箭电泳法对64例(80例次)肺性病患者进行血浆纤维连接蛋白(Fn)测定。合并肺性脑病19例,并与106例健康人及104例其他呼吸疾患进行对比.结果表明:正常组、肺性病缓解组、急性发作组、肺性脑病组血浆Fn水平分别为34.27±6.36mg/dl,29.61±4.25ms/dl,15.21±5.20mg/dl,11.82±5.67mg/dl.肺性脑病患者血浆Fn显著降低,并随病情恶化而进一步下降。同时,其含量变化与pH值和PaO2呈正相关,与PaCO2,呈负相关。因此动态观察肺性脑病患者血浆Fn含量可作为判断顶后一项较为可靠的指标。 相似文献
49.
YUKAKO ISHIHARA MASAHIRO SEIKE ITARU YOKOUCHI HIROAKI SUDA SHUNICHIRO ISHITSUKA TADAYOSHI KAKEMURA MITSUHIRO YOSHIDA KAZUYA YOSHIMOTO YOSHIHIRO SAKAI CHIDORI OKUMURA YOSHIHISA SAIDA 《Digestive endoscopy》2003,15(3):240-242
A 55‐year‐old‐man had a laparoscopic resection of the sigmoid colon due to colon cancer with submucosal invasion. After the surgery he suffered ileus and had a laparotomy. Six months later he complained of frequent defecation. Colonoscopy confirmed a circular ulcer extending from the anal side of the anastomosis in the sigmoid colon to the mid rectum. Endoscopic ultrasound demonstrated thickening of all layers of the diseased colon and rectum. We diagnosed ischemic colitis. After intravenous drip infusion of prostaglandin, symptoms and colonic stricture gradually improved. Although abdominal angiography revealed a narrowing of the peripheral sigmoid branch of the inferior mesenteric artery, blood flow was unrestricted. Colonoscopy performed 84 days after discharge revealed an ulcer scar. 相似文献
50.
Comparison of Asymmetry in Cerebral Blood Flow Between Brain Hemispheres Using Digital Subtraction Angiography 总被引:2,自引:0,他引:2
Afshin A. Divani PhD Adnan I. Qureshi MD Kenneth R. Hoffman PhD M. Fareed K. Suri MD Jawad F. Kirmani MD 《Journal of neuroimaging》2006,16(2):139-145
BACKGROUND AND PURPOSE: Recently, endovascular techniques have gained significant therapeutic potential for both treatment and prevention of stroke. Cerebral angiography, which is an essential component of these procedures, has been used to provide morphological information regarding condition of blood vessels. In this study, we propose to determine the possibility of acquiring information regarding cerebral blood flow (CBF) in addition to morphologic information from data routinely available during angiography. METHODS: Digital subtraction angiography sequences were obtained for eight patients having occlusive disease in internal carotid artery (ICA) territories. Two regions-of-interest (ROIs) corresponding to the two brain hemispheres on AP view were delineated. For each image, the average pixel value within each ROI was calculated and used to generate time-density curves. Indices obtained from each curve were compared with each other and with the results obtained from the single photon emission computed tomography (SPECT) studies performed a pre- or postangiography procedure. RESULTS: Comparison between ICA stenosis and cerebral perfusion measurements revealed that cerebral perfusion deficit can be independent of arterial occlusive disease. The indices obtained from the time-density curves exhibit a correlating trend with the results from SPECT studies. However, lack of sufficient sample data prevented any meaningful statistical analysis to be conducted. CONCLUSIONS: We have developed a technique for utilizing the angiographic data for the important task of routinely and easily measuring CBF. Availability of CBF measurements during cerebral angiography may favorably impact upon the appropriate use of endovascular procedures and potentially contribute to the reduction of morbidity and mortality associated with stroke. 相似文献