Effect of transient scrotal hyperthermia on sperm parameters,seminal plasma biochemical markers,and oxidative stress in men

In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate whether different frequencies of heat exposure cause different degrees of damage to spermatogenesis. Two groups of volunteers (10 per group) received testicular warming in a 43°C water bath 10 times, for 30 min each time: group 1: 10 consecutive days; group 2: once every 3 days. Sperm parameters, epididymis and accessory sex gland function, semen plasma oxidative stress and serum sex hormones were tested before treatment and in the 16-week recovery period after treatment. At last, we found an obvious reversible decrease in sperm concentration (P = 0.005 for Group 1 and P= 0.008 for Group 2 when the minimums were compared with baseline levels, the same below), motility (P = 0.009 and 0.021, respectively), the hypoosmotic swelling test score (P = 0.007 and 0.008, respectively), total acrosin activity (P = 0.018 and 0.009, respectively), and an increase in the seminal plasma malondialdehyde concentration (P = 0.005 and 0.017, respectively). The decrease of sperm concentration was greater for Group 2 than for Group 1 (P = 0.031). We concluded that transient scrotal hyperthermia seriously, but reversibly, negatively affected the spermatogenesis, oxidative stress may be involved in this process. In addition, intermittent heat exposure more seriously suppresses the spermatogenesis compared to consecutive heat exposure. This may be indicative for clinical infertility etiology analysis and the design of contraceptive methods based on heat stress.     

Anesthetic considerations in myofibrillar myopathy

Myofibrillar myopathy (MFM) is a relatively newly recognized genetic disease that leads to progressive muscle deterioration. MFM has a varied phenotypic presentation and impacts cardiac, skeletal, and smooth muscles. Affected individuals are at increased risk of respiratory failure, significant cardiac conduction abnormalities, cardiomyopathy, and sudden cardiac death. In addition, significant skeletal muscle involvement is common, which may lead to contractures, respiratory insufficiency, and airway compromise as the disease progresses. This study is the first report of anesthetic management of a patient with MFM. We report multiple anesthetic encounters of a child with genetically confirmed BAG3‐myopathy, a subtype of MFM with severe childhood disease onset. A review of the anesthetic implications of the disease is provided, with specific exploration of possible susceptibility to malignant hyperthermia, rhabdomyolysis, and sensitivity to other anesthetic agents.     

深部热疗联合化疗在晚期小细胞肺癌中的疗效观察

目的探讨深部热疗结合化疗在晚期小细胞肺癌中的临床效果。方法将80例晚期小细胞肺癌患者随机平均分成治疗组和对照组,每组各40例。2组患者均采用依托泊苷联合顺铂常规化疗治疗,治疗组患者在化疗同时给予肺部原发病灶深部热疗;比较6周期后两组患者的缓解率、无进展生存期、体能变化及不良反应。结果治疗组患者的缓解率为85.0%,对照组患者的缓解率为67.5%,治疗组缓解率显著高于对照组(P<0.05);治疗组的无进展生存期明显高于对照组(P<0.05);治疗组KPS评分较化疗前明显增加(P<0.05),对照组KPS评分较化疗前比较差异无统计学意义;2组患者的恶心、呕吐、及骨髓抑制程度明显低于对照组,但均无统计学意义(P>0.05)。结论晚期小细胞肺癌患者在化疗的同时联合深部热疗可显著提高患者的化疗疗效,延长患者生存时间,减轻患者化疗的不良反应,提高患者生存质量。     

超声热化疗联合根治性手术在口腔颌面部晚期鳞癌患者中的应用及护理

目的 研究超声热化疗在口腔颌面部晚期鳞癌患者中的应用效果及围术期护理。方法 以我院就诊的36例口腔颌面部晚期鳞癌患者为研究对象,将其分为对照组和实验组,每组18人。对照组只进行化疗,然后进行手术治疗。实验组采用上海熙洛有限公司生产的YUT-1超声肿瘤热疗仪热疗加化疗后实施手术方案。结果 术后一年比较治疗效果。热化疗组和化疗组的RR分别为77.8%和38.9%,热化疗组的RR明显高于化疗组（P<0.05）。结论 超声热化疗联合根治性手术共同治疗口腔颌面部的晚期鳞癌,有明显的加强和增敏效果,治疗的同时会使患者大量出汗,疲劳,甚至灼伤热疗区域的皮肤。对此,我们要加强热化疗患者的围术期护理工作,提高疗效,提高晚期癌症患者的生存质量。     

腹腔热疗联合TP方案治疗中晚期卵巢癌的临床观察

目的:观察TP方案化疗联合腹腔热疗与单纯静脉化疗治疗中晚期卵巢癌的疗效及毒副反应。方法:87例患者根据随机表随机分为对照组(45例)与观察组(42例)。对照组采用TP方案,即多西他赛75 mg/m2(d1)联合顺铂70 mg/m2(d1)静脉滴注,21 d为1个周期;观察组采用静脉滴注多西他赛75 mg/m2(d1)、腹腔灌注顺铂70 mg/m2(d1),灌注后行腹腔微波热疗,每周2次,21 d为1个周期。结果:对照组与观察组的总有效率分别为37.8%、64.3%(P=0.047)。治疗后,两组患者血清中糖类抗原125(CA125)较治疗前明显下降,且观察组患者下降的幅度明显高于对照组(P<0.001);毒副反应主要为肌肉酸痛及骨髓抑制。结论:TP方案联合腹腔热疗可明显提高中晚期卵巢癌的总有效率,且毒副反应未明显增加。     

Local Induction Heating Capabilities of Zeolites Charged with Metal and Oxide MNPs for Application in HDPE Hydrocracking: A Proof of Concept

Zeolites are widely used in high-temperature oil refining processes such as fluid catalytic cracking (FCC), hydrocracking, and aromatization. Significant energy cost are associated with these processes due to the high temperatures required. The induction heating promoted by magnetic nanoparticles (MNPs) under radio frequency fields could contribute to solving this problem by providing a supplementary amount of heat in a nano-localized way, just at the active centre site where the catalytic process takes place. In this study, the potential of such a complementary route to reducing energetic requirements is evaluated. The catalytic cracking reaction under a hydrogen atmosphere (hydrocracking) applied to the conversion of plastics was taken as an application example. Thus, a commercial zeolite catalyst (H-USY) was impregnated with three different magnetic nanoparticles: nickel (Ni), cobalt (Co), maghemite (γ-Fe₂O₃), and their combinations and subjected to electromagnetic fields. Temperature increases of approximately 80 °C were measured for H-USY zeolite impregnated with γ-Fe₂O₃ and Ni-γ-Fe₂O₃ due to the heat released under the radio frequency fields. The potential of the resulting MNPs derived catalyst for HDPE (high-density polyethylene) conversion was also evaluated by thermogravimetric analysis (TGA) under hydrogen atmosphere. This study is a proof of concept to show that induction heating could be used in combination with traditional resistive heating as an additional energy supplier, thereby providing an interesting alternative in line with a greener technology.