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51.
《Journal of vascular and interventional radiology : JVIR》2021,32(8):1227-1230
The clinical outcomes of major bleeding events following ultrasound-guided native and allograft parenchymal renal biopsy were evaluated. Forty-eight bleeding complications after biopsy (Society of Interventional Radiology adverse event grade ≥ 2) from 2002 to 2018 were identified. The primary outcome assessed was renal function. The clinical outcomes and interventions performed, including blood transfusion, angiography with or without embolization, nephrostomy tube placement, surgery, nephrectomy, hospitalization, intensive care unit admission, dialysis, and survival, were noted. Renal function may be moderately diminished in the short-term periprocedural setting. None of the patients studied died or required nephrectomy or the initiation of dialysis as a result of a major bleeding complication after the renal biopsy. 相似文献
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Alireza Aminsharifi Lauren E. Howard Christopher L. Amling William J. Aronson Matthew R. Cooperberg Christopher J. Kane Martha K. Terris Thomas J. Polascik Stephen J. Freedland 《Clinical genitourinary cancer》2019,17(1):e140-e149
Purpose
To investigate the preoperative use of combination metformin and statin versus monotherapy on biochemical recurrence (BCR) after radical prostatectomy (RP) in diabetic men.Patients and Methods
Data of 843 diabetic men who underwent RP were stratified on the basis of preoperative use of no drug or of metformin, statin, or both. Multivariable Cox models were used to test the association between treatment and BCR. In a secondary analysis, models were stratified by race and body mass index (BMI) and further adjusted for glycated hemoglobin (HbA1c).Results
A total of 259 men (31%) received statin therapy, 94 (11%) metformin, 307 (36%) metformin + statin, and 183 (22%) neither. Five-year BCR-free survival rates were 75% in metformin only versus 75% in metformin + statin versus 60% in statin versus 68% in no drug groups (log-rank, P = .003). On multivariable analysis, preoperative statin use was associated with increased BCR risk versus men receiving neither drug (hazard ratio [HR] = 1.84; 95% confidence interval [CI], 1.28-2.64). Metformin alone (HR 0.88; 95% CI, 0.53-1.47) and metformin + statin (HR 0.88; 95% CI, 0.58-1.33) were unrelated to BCR risks. In secondary analysis, the association between statin use and higher BCR risk was similar regardless of race, but was stronger among men with BMI ≥ 30 kg/m2 (HR 3.12; 95% CI, 1.70-5.72). These results were largely unchanged after adjusting for HbA1c.Conclusion
Among diabetic men undergoing RP, preoperative statin use was associated with worse BCR risk, especially among men with a high BMI, but these associations may be mitigated by concomitant use of metformin. If validated in future findings, research is needed to understand the basis for these associations. 相似文献53.
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《Chest》2020,157(5):1322-1345
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CircRNA是非编码RNA中最为稳定的RNA分子,其稳定存在于各种生物体中并参与生物体的代谢功能调节。近年来,大量研究从基因组学及信号通路方向深入研究,发现CircRNA可与miRNA通过复杂调控参与机体各种疾病的发生及发展,其中CircRNA在肿瘤细胞的增殖、凋亡及转移中的作用备受瞩目。妇科肿瘤是妇科疾病中危害最大的疾病。本文主要从CircRNA的特征功能认知、在肿瘤发生及发展中途径、以及其在妇科肿瘤中的致病机理和未来诊断方向上,综合国内外相关研究进展进行整理,总结CircRNA在妇科肿瘤中的临床应用。 相似文献
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